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a novel germline gain-of-function Galpha11 mutation, Val340Met, causing Autosomal Dominant Hypocalcemia Type 2 demonstrates the importance of the Galpha11 C-terminal region for G-protein function and CaSR (show CASR ELISA Kits) signal transduction.
studies have identified a third Galpha11 mutation (Thr54Met) causing Familial Hypocalciuric Hypercalcemia Type 2 and reveal a critical role for the Galpha11 interdomain interface in CaSR (show CASR ELISA Kits) signaling and Ca(2 (show CA2 ELISA Kits)+) o homeostasis.
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (show SOX10 ELISA Kits) expression and presence of the BRAF (show BRAF ELISA Kits) V600E mutation.
Mutations in GNAQ (show GNAQ ELISA Kits) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (show GNAQ ELISA Kits), GNA11, and EIF1AX (show EIF1AX ELISA Kits) mutations.
GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.
CGRP (show S100A12 ELISA Kits) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS ELISA Kits), Galphai, and Galphaq (show GNAQ ELISA Kits)/11 pathways.
The identified GNA11 mutation results in biochemical abnormalities typical for autosomal dominant hypocalcemia. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation.
In 33 CASR (show CASR ELISA Kits)-negative patients with suspected FHH (show CASR ELISA Kits), Data found two (~6%) with a mutation in AP2S1 (show AP2S1 ELISA Kits) (p.Arg15Leu and p.Arg15His). Family screening confirmed the genotype-phenotype correlations. Data did not identify any pathogenic mutations in GNA11.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone (show PTH ELISA Kits) and exercise
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (show TGFB1 ELISA Kits) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (show IL33 ELISA Kits) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (show GNAQ ELISA Kits)/11-dependent fashion.
claudin-3 (show CLDN3 ELISA Kits) and claudin-5 (show CLDN5 ELISA Kits) expression is increased by DHEAS (show SULT2A1 ELISA Kits) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (show GNAQ ELISA Kits)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (show OPN4 ELISA Kits) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (show GNAQ ELISA Kits)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 ELISA Kits))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 ELISA Kits), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 ELISA Kits)-induced stimulation of Erk1/2 (show MAPK1/3 ELISA Kits), ATF-1 (show AFT1 ELISA Kits), and CREB (show CREB1 ELISA Kits).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (show MAPK1 ELISA Kits) cascade via the Galpha(q (show GNAQ ELISA Kits)/11)--p63RhoGEF--RhoA (show RHOA ELISA Kits) axis.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit