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Human Polyclonal Arylsulfatase B Primary Antibody for IHC (p), IHC - ABIN449528
Bhattacharyya, Look, Tobacman: Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR. in Clinica chimica acta; international journal of clinical chemistry 2007
Of the 20 patients included in the study, molecular genetic analysis was performed on 17 patients... molecular analysis results of four patients who was excluded from the overall study (three of which were another adult male siblings who did not receive ERT (show ELF3 Antibodies) and one patient whose ERT (show ELF3 Antibodies) duration was shorter than 6 months) were were included in determination of allele frequency of ARSB.
Three novel mutations in ARSB were detected, expanding the mutational spectrum of ARSB causing MPS VI. A compound heterozygous for the c.464G>A (p.C155Y) and c.1163G>C (p.R388T) mutations, a 13.8-kb deletion encompassing exons 2 and 3, mutation c.479G>A (p.R160Q), and novel c.464G>A (p.C155Y) mutation.
Nine novel mutations of ARSB were identified in MPS VI cases from India in the present study. The study also provides some insights into the genotype-phenotype association in MPS VI
Silencing Wnt9A (show WNT9A Antibodies) increased the expression of CHST11 (show CHST11 Antibodies) in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A (show WNT9A Antibodies) siRNA and exogenous BMP4 (show BMP4 Antibodies) on the CHST11 (show CHST11 Antibodies) promoter
Arylsulfatase B regulates versican (show Vcan Antibodies) expression by galectin-3 (show LGALS3 Antibodies) and AP-1 (show FOSB Antibodies) mediated transcriptional effects.
Mutation analysis of the ARSB gene revealed seven missense and three frameshift mutations of which eight were novel.
These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S (show CHST11 Antibodies), galectin-3 (show LGALS3 Antibodies), Sp1 (show PSG1 Antibodies), and Wnt9A (show WNT9A Antibodies)
ARSB activity was significantly higher in the normal tissues.
PTC124 but not gentamicin, increases the level of ARSB activity.
results indicate that mammalian ARSB improves functional recovery after CNS injury.
Arylsulfatase B regulates versican (show Vcan Antibodies) expression by galectin-3 (show LGALS3 Antibodies) and AP-1 (show JUN Antibodies) mediated transcriptional effects.
These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S (show CHST11 Antibodies), galectin-3 (show LGALS3 Antibodies), Sp1 (show SP1 Antibodies), and Wnt9A (show WNT9A Antibodies)
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, arylsulfatase B complex
, arylsulfatase B regulation
, arylsulfatase B structural
, arylsulfatase B temporal regulation
, Arylsulfatase B (MPS VI)
, arylsulfatase B
, arylsulfatase b
, Arylsulfatase B
, arylsulfatase B-like