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This study demonstrated that elevated B3GNT3 expression is associated with pelvic lymph node metastasis and poor outcome in early-stage cervical cancer patients.
B3GNT3 predicts a favorable cancer behavior of neuroblastoma (show ARHGEF16 Proteins) and suppresses malignant phenotypes by modulating mucin (show SLC13A2 Proteins)-type O-glycosylation and signaling in neuroblastoma (show ARHGEF16 Proteins) cells.
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8
, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
, beta-1,3-GalTase 8
, beta-1,3-N-acetylglucosaminyltransferase bGnT-3
, core 1 extending beta-1,3-N-acetylglucosaminyltransferase
, putative type II membrane protein
, transmembrane protein 3
, beta-1,3-N-acetylglucosaminyltransferase 3
, core 1 beta-1,3-N-acetylglucosaminyltransferase