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These results have demonstrated that CHST11 and CHST13 negatively modulate metastasis and drug resistance of HCC cells probably via oncogenic MAPK signal pathway.
human D4ST-1, C4ST-1, and S4ST-2 have differential roles in dermatan sulfate biosynthesis
chondroitin 4-O-sulfotransferase-2 efficiently transferred sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 4 of non-reducing terminal GalNAc-linkage residues forming chondroitin sulfate.
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene.
carbohydrate sulfotransferase 12
, chondroitin 4-O-sulfotransferase 2
, chondroitin 4-sulfotransferase 2
, sulfotransferase Hlo