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Recombinant 3-OST-5 only exhibited sulfotransferase activity toward heparan sulfate and heparin. 3-OST-5 was highly expressed in fetal brain, followed by adult brain and spinal cord, and at very low or undetectable levels in other tissues.
Results demonstrate that the human 3-O-sulfotransferase isoform 5 gene (show GPD1 ELISA Kits) is capable of synthesizing anticoagulant heparan sulfate (HS) in CHO (show COL11A1 ELISA Kits) cells and may contribute to the biosynthesis of HS in humans.
Structural analysis of 3-OST-5 HS(act) revealed that the antithrombin (show SERPINC1 ELISA Kits)-binding site of 3-OST-5 HS(act) is located within a domain clustered with N-sulfated (show SULF1 ELISA Kits) glucosamine units.
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 188.8.131.52) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003
, heparan sulfate 3-O-sulfotransferase 5
, heparan sulfate 3-OST-5
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
, heparan sulfate glucosamine 3-O-sulfotransferase 5
, heparan sulfate (glucosamine) 3-O-sulfotransferase 5
, heparan sulfate 3-O-sulfotransferase 6
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
, heparan sulfate glucosamine 3-O-sulfotransferase 6
, heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like
, heparan sulfate (glucosamine) 3-O-sulfotransferase 6