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NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin (show PTN Proteins) and osteoglycin.
Increased serum mimecan is associated with poor angiographic coronary collateralization in patients with chronic total occlusion
the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD (show BEST1 Proteins)), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported.
OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF (show VEGFA Proteins)-VEGFR2 (show KDR Proteins) signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4 (show TLR4 Proteins).
mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin (show LEP Proteins) signaling by inducing IL-1beta (show IL1B Proteins) and IL-6 (show IL6 Proteins) expression in the hypothalamus.
Increased plasma mimecan levels are independently associated with increased arterial stiffness in hypertensive patients.
OIF may be an indicator of the earlier-stage diabetic nephropathy in subjects with type 2 diabetes mellitus
OGN might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
Osteomodulin (show OMD Proteins), osteoglycin, and asporin (show ASPN Proteins) appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
These results reveal a novel pathway in which miR (show MLXIP Proteins)-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells.
elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase (show MAPK1 Proteins)/activator protein 1 (show JUN Proteins) pathway (MAPK (show MAPK1 Proteins)/AP-1 (show JUN Proteins)).
lack of the proteoglycan (show Vcan Proteins) OGN does not affect the progression of atherosclerosis in mice
The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice.
Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues.
The temporal-spatial specific pattern and unique co-localization of Dspp (show DSPP Proteins), Mepe, Mimecan and Versican (show Vcan Proteins) suggest they play complementary roles during odontogenesis.
From our study we conclude that downregulation of osteoglycin is a fundamental requirement for proper arteriogenesis
Mapping of the OGN and ASPN (show ASPN Proteins) genes and association with growth and carcass traits.
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene.
corneal keratan sulfate proteoglycan
, mimecan proteoglycan
, osteoinductive factor
, osteoglycin (osteoinductive factor)
, osteoglycin (osteoinductive factor, mimecan)
, osteoglycin preproprotein