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PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2]
High SLC35B2 expression is associated with invasive ductal breast carcinoma.
Results suggest that frequently downregulated miR-22 expression is associated with cell proliferation in medulloblastomas, and this may be at least in part via PAPST1, which is a novel target of miR-22
PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status.
PAPS1 has roles in PAPS transport and post-translational sulfation
Sulfotransferases (e.g., SULT4A1\; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003
adenosine 3-phospho 5-phosphosulfate transporter 1
, PAPS transporter 1
, adenosine 3'-phospho 5'-phosphosulfate transporter 1
, solute carrier family 35, member B1
, solute carrier family 35, member B2
, 3'-phosphoadenosine 5'-phosphosulfate transporter
, putative MAPK-activating protein PM15
, putative NF-kappa-B-activating protein 48
, solute carrier family 35 member B2 variant 2
, NF-kappa-B inhibitor epsilon
, 3'-phosphoadenosine 5'-phosphosulfate transporter 1