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anti-Human WISP1 Antibodies:
anti-Mouse (Murine) WISP1 Antibodies:
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Human Polyclonal WISP1 Primary Antibody for IHC (p), ELISA - ABIN545759
Soon, Yie, Shvarts, Levine, Su, Tchou-Wong: Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. in The Journal of biological chemistry 2003
Show all 3 Pubmed References
Human Polyclonal WISP1 Primary Antibody for IHC (p), WB - ABIN390187
Hocevar, Mou, Rennolds, Morris, Cooper, Howe: Regulation of the Wnt signaling pathway by disabled-2 (Dab2). in The EMBO journal 2003
Show all 4 Pubmed References
Human Polyclonal WISP1 Primary Antibody for ELISA, WB - ABIN548043
Major, Camp, Berndt, Yi, Goldenberg, Hubbert, Biechele, Gingras, Zheng, Maccoss, Angers, Moon: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. in Science (New York, N.Y.) 2007
Human Polyclonal WISP1 Primary Antibody for IF (p), IHC (p) - ABIN872843
Xu, Zhao, Zhang, Xu, Yang, Wang, Liu: Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats. in Clinical and experimental pharmacology & physiology 2015
Urothelial cell carcinoma carrying WISP1 rs2977530 genetic variants (AG + GG) have a higher risk of developing a more invasive tumor stage and a large tumor.
Study shows that WISP1 expression is significantly upregulated in glioblastoma tissue and cell lines. Also, WISP1 seems to be an important regulator of glioblastoma cell proliferation, apoptosis, migration, invasion, and TMZ drug resistance. WISP1 mediates these biological processes through regulating critical gene expression and pathways that are involved in cancer progression.
WISP1 has a role in colon cancer apoptosis, invasion and poor prognosis
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
There is a relationship between WISP1 and the metabolic parameters of gestational diabetes (GDM). And, WISP1 might be involved in the pathophysiology of GDM.
Macrophage-derived IL-10 has a role in mediating mucosal repair by epithelial WISP-1 signaling
results demonstrate that a joint effect of WISP1 rs2929970 with smoking as well as WISP1 rs16893344 with betel nut chewing causally contributes to the occurrence of OSCC. WISP1 polymorphism may serve as a marker or a therapeutic target in OSCC
Taken together, our findings presented the first evidence that Wnt1-inducible signaling pathway protein-1 was upregulated in gastric cancer and acted as an oncogene by promoting proliferation, migration, and invasion in gastric cancer cells.
findings reveal that WISP-1 enhances VEGF-A expression and angiogenesis through the FAK/JNK/HIF-1alpha signaling pathways, as well as via down-regulation of miR-381 expression.
Akt signaling pathway mediates WISP1-induced migration and proliferation of human VSMCs
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut.
Data show that WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 expression was correlated with vascular endothelial growth factor-C (VEGF-C) expression in Oral squamous cell carcinoma (OSCC) specimens.
WISP1-induced IL-6 expression contributes to the pro-proliferative effect on fibroblasts.
WISP1 plays an important role in regulating proliferation and apoptosis of Jurkat cells.
Study showed that DNA methylation of the WISP1 promoter in the majority of the oral squamous cell carcinoma explains its expression regulation.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3.
Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors. [review]
WISP1 contributed to radioresistance primarily by repressing irradiation-induced DNA damage and activating PI3K kinase.
WISP1 functions as an oncogene for human breast cancer. Ectopic expression of WISP1 in breast cancer cells promotes cell growth and metastasis.
Two paralogs of mammalian wisp1 genes were found in zebrafish.
WISP1 interacts with PPARgamma and that this interaction results in the inhibition of PPARgamma activity. T
WISP1 plays an aggravating role in the development of post-traumatic experimental OA.
Data revealed that reconstituted overexpression of WISP-1 could largely reverse the Notch1-/--induced metastasis-promoting effect of mesenchymal stem cell-derived stromal fibroblasts (MSC-DF); thus, demonstrating that the Notch1-determined melanoma metastasis-regulating role of MSC-DF is mediated primarily by WISP-1.
Upregulation of Wnt2 expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4/TRIF signaling.
the Bmp3/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin resistance and could be a novel therapeutic target for obesity.
Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress.
Notch1-induced WISP-1 expression appeared to be Wnt11-dependent, but Wnt1-independent
WISP-1 exerts paracrine action on immune cells by inhibiting their response to IL12
WISP1 is an endogenous signal that acts through TLR4 signaling to increase alveolar-capillary permeability in ventilator-induced lung injury.
WISP-1 has a positive influence on bone cell differentiation and function and may work by enhancing the effects of BMP-2
WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast proliferation, and ECM expression in vitro. These results suggest that WISP-1 may play a critical role in post-myocardial infarction remodeling.
Results show that NO increases WISP-1 expression, and suggest a new role for iNOS and NO in colitis.
expression of WISP1 was increased in alveolar epithelial type II cells in a model of pulmonary fibrosis
A TNF-alpha/WISP1 signaling pathway may contribute to post-infarct cardiac remodeling, a condition characterized by fibrosis and progressive cardiomyocyte loss.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein
, WNT1 inducible signaling pathway protein 1