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Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling.
In conclusion, we identified two genes, DZIP1 and XYLT1, potentially associated with nonsyndromic high myopia using whole exome sequencing and subsequent mutation screening analysis.
centrosome protein Dzip1 mediates the assembly of the BBSome-Dzip1-PCM1 complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 at Ser-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 and the BBSome from the CS.
The abundance of DZIP1-associated mRNAs increased with treatment.
gene expression profiling [DZIP]
Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish.
critical component of ciliogenesis
Igu/Dzip1 functions as a permissive factor that is required for the proper regulation of Hh target genes in response to Hh signals.
zebrafish iguana gene product acts in the somites of the developing embryo and can shuttle between the cytoplasm and nucleus in a manner correlated with Hedgehog pathway activity.
Results indicate that a critical and broadly conserved function for Iguana is in ciliogenesis and that this function has come to be required for Hedgehog signaling in vertebrates
Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo.
DAZ interacting protein 1
, DAZ-interacting protein 1 homolog
, zinc finger protein DZIP1
, DAZ interacting protein testis1
, DAZ-interacting protein 1/2
, zinc finger DAZ interacting protein 1
, zinc-finger protein DZIPt1
, iguana protein
, zin finger protein igu/dzip1
, zinc finger protein Dzip1