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Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened
HHIP G516R, a missense mutation increased cell proliferation and promoted cell migration in thyroid cancer.
The rate of methylation of ZIC1, ZIC4, HHIP, and DACT2 in tumors was very high, while methylation of CXXC4 was low to moderate in OSCC and LSCC.
Genetic variants in HHIP were related with FEV1/FVC in Chronic Obstructive Pulmonary Disease (COPD). Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD were also identified.
HHIP underexpression is associated with lung adenocarcinoma.
HHIP plays a role in lung branching development, and reduced levels of HHIP ultimately result in lung hypoplasia.
Single nucleotide polymorphism in HHIP gene is associated with chronic obstructive pulmonary disease.
loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes
this study shows that HHIP confers a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease
Results showed that smoking and HHIP variant rs7654947 were associated with chronic obstructive pulmonary disease (COPD)development and lung function decline. Moreover, we found that cigarette smoking and gene susceptibility have cooperative effects on COPD risk and lung function decline
This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD.
HHIP expression and Gli1 expression were independent prognostic factors in glioblastoma.
HHIP - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.
Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling.
HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease.
HHIP is located within genes previously associated with chronic obstructive pulmonary disease susceptibility.
Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease.
The data demonstrated that loss of expression of HHIP and PTCH is associated with the methylation of gene promoters
We show that GPC3, an hepatocellular carcinoma biomarker and Hh mediator, regulates human stellate cell viability by regulating Hh signaling.
Data indicate that the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch, and show the complex structure of Shh-Hhip.
our study suggests that the HHIP gene may be involved in COPD susceptibility in Chinese Han population.
Localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of olfactory and lens placodes.
The HHIP gene that is known to be associated with stature in humans was strongly associated with direct calving difficulty in the present study.
To explore the molecular pathways which contribute to increased susceptibility, we performed metabolomic profiling using high performance liquid chromatography tandem mass spectroscopy (LC/MS-MS) on plasma, urine, and lung tissue of Hhip (+/-) heterozygotes and wild type (Hhip (+/+)) C57/BL6 mice exposed to either room-air or cigarette smoke for six months.
reduced lung function and age-related spontaneous emphysema development in Hhip(+/-) mice may be caused by increased oxidative stress levels in murine lungs as a result of haploinsufficiency of Hhip.
the heterozygous knockdown of hhip in mice could affect Hh signaling in tumor fibroblasts, which could cause the increased production of the growth factor VEGF. This signaling, via a paracrine effect on endothelial cells, increased tumor vascular density.
PTCH1, PTCH2 and HHIP1 all contribute to ligand-dependent antagonism of sonic hedgehog signaling.
Estradiol improves the recovery of injured nerves by downregulating the Shh inhibitor hedgehog-interacting protein and increasing Shh-induced angiogenesis.
These results suggest that reduced expression of HIP, a naturally occurring Hh pathway antagonist, in tumor neo-vasculature may contribute to increased Hh signaling within the tumor and possibly promote angiogenesis.
hedgehog antagonists patched 1 and Hhip1 have roels in growth and pattern of the mammalian neural tube
hypothesis for a functional link between nitric oxide and Shh signaling and for a nonredundant role of Hip and Ptc1 in the adult brain
These data indicate that Hh signaling plays a role in adult gut epithelial homeostasis by regulating epithelial cell migration from crypt to villus tip and by enhancing apoptosis.
These results strongly suggest that GSK3beta phosphorylates Sufu to positively regulate Hedgehog signaling in mammalian cells.
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.
, hedgehog-interacting protein
, Hedgehog-interacting protein-like
, hedgehog interacting protein
, hedgehog-interacting protein-like