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Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened
The rate of methylation of ZIC1 (show ZIC1 Proteins), ZIC4 (show ZIC4 Proteins), HHIP, and DACT2 (show DACT2 Proteins) in tumors was very high, while methylation of CXXC4 (show CXXC4 Proteins) was low to moderate in OSCC and LSCC.
Genetic variants in HHIP were related with FEV1/FVC in Chronic Obstructive Pulmonary Disease (COPD (show ARCN1 Proteins)). Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD (show ARCN1 Proteins) were also identified.
HHIP underexpression is associated with lung adenocarcinoma.
HHIP plays a role in lung branching development, and reduced levels of HHIP ultimately result in lung hypoplasia.
Single nucleotide polymorphism in HHIP gene is associated with chronic obstructive pulmonary disease.
loss of AT2 R (show AGTR2 Proteins) is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes
this study shows that HHIP confers a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease
Results showed that smoking and HHIP variant rs7654947 were associated with chronic obstructive pulmonary disease (COPD (show ARCN1 Proteins))development and lung function decline. Moreover, we found that cigarette smoking and gene susceptibility have cooperative effects on COPD (show ARCN1 Proteins) risk and lung function decline
This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD.
HHIP expression and Gli1 (show GLI1 Proteins) expression were independent prognostic factors in glioblastoma.
Localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of olfactory and lens placodes.
The HHIP gene that is known to be associated with stature in humans was strongly associated with direct calving difficulty in the present study.
reduced lung function and age-related spontaneous emphysema development in Hhip(+/-) mice may be caused by increased oxidative stress levels in murine lungs as a result of haploinsufficiency of Hhip.
the heterozygous knockdown of hhip in mice could affect Hh signaling in tumor fibroblasts, which could cause the increased production of the growth factor VEGF (show VEGFA Proteins). This signaling, via a paracrine effect on endothelial cells, increased tumor vascular density.
PTCH1 (show PTCH1 Proteins), PTCH2 (show PTCH2 Proteins) and HHIP1 all contribute to ligand-dependent antagonism of sonic hedgehog (show SHH Proteins) signaling.
Estradiol improves the recovery of injured nerves by downregulating the Shh (show SHH Proteins) inhibitor hedgehog-interacting protein and increasing Shh (show SHH Proteins)-induced angiogenesis.
hedgehog (show SHH Proteins) antagonists patched 1 (show PTCH1 Proteins) and Hhip1 have roels in growth and pattern of the mammalian neural tube
hypothesis for a functional link between nitric oxide and Shh (show SHH Proteins) signaling and for a nonredundant role of Hip and Ptc1 (show PTCH1 Proteins) in the adult brain
These data indicate that Hh signaling plays a role in adult gut (show GUSB Proteins) epithelial homeostasis by regulating epithelial cell migration from crypt to villus tip and by enhancing apoptosis.
These results strongly suggest that GSK3beta phosphorylates Sufu (show SUFUH Proteins) to positively regulate Hedgehog (show SHH Proteins) signaling in mammalian cells.
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.
, hedgehog-interacting protein
, Hedgehog-interacting protein-like
, hedgehog interacting protein
, hedgehog-interacting protein-like