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anti-Human Sonic Hedgehog Antibodies:
anti-Mouse (Murine) Sonic Hedgehog Antibodies:
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Human Polyclonal Sonic Hedgehog Primary Antibody for IF (p), IHC (p) - ABIN731108
Weiss, Guo, Shan, Shi, Romano, Sinha, Cantley, Guo: Brg1 determines urothelial cell fate during ureter development. in Journal of the American Society of Nephrology : JASN 2013
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, WB - ABIN969395
Dierker, Dreier, Migone, Hamer, Grobe: Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. in The Journal of biological chemistry 2009
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Human Polyclonal Sonic Hedgehog Primary Antibody for ICC, IF - ABIN4355160
Palacio-Mancheno, Evashwick-Rogler, Laudier, Purmessur, Iatridis: Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1970
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, WB - ABIN967021
Lee, Lee, Jung, Park, Park, Hahm: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. in Cancer letters 2010
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, FACS - ABIN4355158
Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. in Tumour biology 2016
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Human Monoclonal Sonic Hedgehog Primary Antibody for FACS - ABIN4897996
Blotta, Jakubikova, Calimeri, Roccaro, Amodio, Azab, Foresta, Mitsiades, Rossi, Todoerti, Molica, Morabito, Neri, Tagliaferri, Tassone, Anderson, Munshi: Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. in Blood 2012
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Human Polyclonal Sonic Hedgehog Primary Antibody for IF, WB - ABIN5663575
Gao, Li, Li: Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway. in American journal of translational research 2018
Human Polyclonal Sonic Hedgehog Primary Antibody for IHC (p), WB - ABIN3043230
Dai, Ai, Du, Chen: Sonic hedgehog expression correlates with distant metastasis in pancreatic adenocarcinoma. in Pancreas 2011
Chicken Polyclonal Sonic Hedgehog Primary Antibody for IHC, IHC (p) - ABIN4893080
Lozito, Tuan: Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. in Development (Cambridge, England) 2016
on a molecular level the human and mouse HH-dependent MB are quite distinct, with human, but not mouse, tumors characterized by the presence of markers of increased oxidative phosphorylation and mitochondrial biogenesis.
Rictor/mTORC2 has opposing functions in neural stem cells and granule cell precursors in the adult and the developing brain, promoting malignant gliomas and suppressing SHH-medulloblastoma formation, respectively.
The SHH pathway was identified in human Rhabdosphincter.Rhabdosphincter growth increased with SHH treatment, indicating intervention may be possible to enhance Rhabdosphincter regeneration
this report present an incomplete phenotype linked to the SHH gene with familial coloboma and microcephaly. It also confirms that WES remains an efficient tool to identify causal genes in atypical phenotypes of well-known genes.
Differential expression of sonic hedgehog in lung adenocarcinoma and lung squamous cell carcinoma
The findings suggest that SHH signaling pathway mediates proliferation and migration of RA-FLSs via MAPK/ERK pathway and may contribute to progression of rheumatoid arthritis (RA).
The results indicate that Shh signaling modulates antioxidant defense system and stabilizes mitochondrial dynamics by suppressing Drp1 protein which maintains survival of endometrial hyperplasial cells against oxidative stress.
Our results manifested that genes involved in SHH signaling pathway showed identical expression patterns, while genes involved in BMP as well as FGF pathway exhibited similar but distinct expression patterns in humans to those in the mouse.
SHH-Patched signal transduction is instrumental for development in Drosophila and for tumor cells communication in humans.
These findings reveal a molecular basis of TSPAN8-enhanced Sonic Hedgehog signaling and highlight a role for TSPAN8 in promoting cancer stemness.
The upregulation of SHH expression in allergic bronchial epithelia contributes to goblet cell metaplasia.
results showed that the microtextured/nanotextured topographies induced significantly high expression of Sonic Hedgehog (SHH), Smoothened (SMO) and GLI1 in the HUVECs as well as high activation of Hedgehog-Gli1 signaling, compared to the smooth surface.
Study reports the cryo-electron microscopy structure of tetrameric PTCH1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog at a 4:2 stoichiometric ratio. The structure shows that four PTCH1 protomers are organized as a loose dimer of dimers.
Overexpression of the Hedgehog signaling components SHH and GLI2 and its target gene FOXA2 in HH were similar to those found in aggressive skin hemangioma and KHE, their expression being significantly higher than in mild skin hemangioma.
Of note, the enforced expression of MEKK1 or the exposure of medulloblastoma cells to the MEKK1 activator, Nocodazole, resulted in a marked inhibitory effect on GLI1 activity and tumor cell proliferation and viability. Taken together, the results of this study shed light on a novel regulatory mechanism of HH signaling, with potentially relevant implications in cancer therapy.
These findings provide novel information on Shh signaling during ischemia in humans, with potentially important biological and clinical implications.
Inversin required for ciliary translocation of Smo and activation of the Shh pathway; Shh signaling promotes inversin phosphorylation by PKA and inversin-Smo interaction
Combined use of SHH and HDAC inhibitors resulted in significantly greater downregulation of SHH and PI3K/mTOR signaling.
ASS1 is associated with sonic hedgehog activation as part of a periportal program expressed in hepatocellular adenomas.
The SHH expression increased during development, shifting from progenitor cells in the proliferative zones to neurons, both glutamatergic and GABAergic, and astrocytes in upper cortical compartments.
The results suggested a second heart field regulatory network comprising of Gata4, Gata6 and SHh-signaling for outflow tract development.
these results implicate Shh signaling as a regulator of mammalian heart regeneration and suggest that modulating this pathway may lead to new potential therapies for cardiovascular diseases.
Our data provide evidence for a new model in which Shh signaling increases in the dorsal forebrain late in embryonic development to provide a temporally regulated mechanism that initiates the third wave of neocortical oligodendrogenesis.
Shh induces adherens junction disruption and integrin beta1-dependent F-actin formation by a mechanism involving FAK/Src and Rac1/Cdc42 signalling pathways in mESCs
Data suggest that the sensitivity of target cells to Sonic Hedgehog (SHH) morphogens, and the consequent effects on gene expression and differentiation outcomes, can be controlled by signals from G protein-coupled receptors.
The results implicate that KLF4 plays important roles for maintaining osteoblasts in an immature state by repressing basal activation of the Hedgehog signaling.
We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium
The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells.
The results of this study indicated that Shh is in the right place at the right time to influence the development of GnRH neurites.
Endogenous Shh does not promote ischaemia-induced angiogenesis. On the contrary, the absence of Shh leads to aberrant ischaemic tissue inflammation and a transiently increased angiogenesis.
Shh protein is produced by contralateral RGCs at the retina, transported anterogradely along the axon, and accumulated at the optic chiasm to repel ipsilateral RGCs. In vitro, contralateral RGC axons, which secrete Shh, repel ipsilateral RGCs in a Boc- and Smo-dependent manner. Knockdown of Shh in the contralateral retina causes a decrease in the proportion of ipsilateral RGCs in a non-cell-autonomous manner.
The results reveal a novel Shh-Foxd1-Cdkn1c regulatory circuit that drives the mitogenic action of Shh signaling. Forkhead box gene Foxd1 is transcriptionally regulated by canonical Shh signaling.
Shh components are also active adjacent to human congenital nevi. Mechanistically, this exacerbation of nevogenesis is driven via the release of the melanocyte mitogen endothelin-1 from keratinocytes. We then suppressed nevus development in mice using Shh and endothelin antagonists
The genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.
Shh is capable of activating the Hh pathway via Smoothened, independently of Patched1/2.
loss of Shh at the late-gestational stage leads to megaesophagus with reduced proliferation and a muscle development disorder in mice.
results indicate that SHH signaling is critically important in the regulation of hematopoietic stem/progenitor cell activation and reprogramming during the granulopoietic response to serious bacterial infection.
Shh signal activation in Wnt active cells promotes the dermal papilla fate in scarring wounds.
quiescent dental stem cells are regulated by Shh signaling.
Shh-signaling-dependent regulation of matrix metalloproteinase9, in turn, regulates Shha levels and genes essential for retina regeneration, such as lin28a, zic2b, and foxn4.
Mutation of hmgcs1 had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 mutants.
Shha/Smo is functionally dedicated to ray branching during fin regeneration.
Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.
Time-lapse imaging revealed that knockdown of miR-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR-219-mediated regulation of apical Par proteins and Shh signaling.
Shh is not essential for the early activation of has2, but supports proper chondrogenic differentiation.
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.
Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis
Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.
We further demonstrate that the elevated Hedgehog signaling in Sox11-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 morphants.
Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.
Sulf1 triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors
These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.
heterozygote mutations in fgf8, shh or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease
Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.
analysis of Hh signaling which induces pancreatic fibrosis through paracrine activation of Hh-responsive cells in vivo
The present study investigates the role of the shha-expressing cells in the patterning of fin ray branches.
The Sphingosine-1-phospate-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not dorsoventral patterning of zebrafish jaw precursors.
function for Bhmt involving modulation of Shh signaling to control beta-cell development.
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish.
SHH-dependent E-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development.
Hh signaling is necessary and sufficient to initiate mouth formation, and Hh activation is required in a dose-dependent fashion to determine the size of the mouth
Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.
Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.
These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.
Connective tissue-specific expression of BMP-4 mRNA is up-regulated by sonic hedgehog.
In an examination of signaling pathways in developing Xenopus lung, shh but not ihh was expressed in the very anterior part of early lung epithelium.
Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.
The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.
Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis
Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos
activated Hedgehog signaling in the blastema and found that target genes of Shh were inducible in the mesenchyme of limb blastema
This study provides further evidence of chondrogenic induction of bone marrow-derived mesenchymal stem cells in vitro via IHH and SHH gene delivery.
The results revealed that the copy number gain type of SHH-CNV exhibited significantly better chest depth in 24 months old Qinchuan cattle, and better body weight, body length, and chest girth in 18 months old Nanyang cattle, whereas the normal copy number had superior chest girth and body weight in adult Jinnan cattle..this research uncovered meaningful effects of SHH-CNV on gene expression and cattle phenotypic traits
study shows evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development
Shh signaling pathway induces myopic development by activating MMP-2 in guinea pigs
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
sonic hedgehog homolog
, sonic hedgehog protein
, hemimelic extra toes
, short digits
, sonic hedgehog protein A
, sonic hedgehog
, sonic hedgehog protein B
, tiggy winkle hedge hog
, tiggy winkle hedgehog
, tiggy-winkle hedgehog protein