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Human Polyclonal Sonic Hedgehog Primary Antibody for IF (p), IHC (p) - ABIN731108
Weiss, Guo, Shan, Shi, Romano, Sinha, Cantley, Guo: Brg1 determines urothelial cell fate during ureter development. in Journal of the American Society of Nephrology : JASN 2013
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, WB - ABIN969395
Dierker, Dreier, Migone, Hamer, Grobe: Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. in The Journal of biological chemistry 2009
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, WB - ABIN967021
Lee, Lee, Jung, Park, Park, Hahm: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. in Cancer letters 2010
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Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, FACS - ABIN4355158
Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. in Tumour biology 2016
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Human Monoclonal Sonic Hedgehog Primary Antibody for FACS - ABIN4897996
Blotta, Jakubikova, Calimeri, Roccaro, Amodio, Azab, Foresta, Mitsiades, Rossi, Todoerti, Molica, Morabito, Neri, Tagliaferri, Tassone, Anderson, Munshi: Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. in Blood 2012
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Human Monoclonal Sonic Hedgehog Primary Antibody for FACS, IHC - ABIN969567
Kameda, Nakamura, Tanaka, Yamasaki, Kubo, Tanaka, Onishi, Katano: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. in British journal of cancer 2010
Human Polyclonal Sonic Hedgehog Primary Antibody for ICC, IF - ABIN4355160
Palacio-Mancheno, Evashwick-Rogler, Laudier, Purmessur, Iatridis: Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1970
Human Polyclonal Sonic Hedgehog Primary Antibody for IHC, ELISA - ABIN1585268
Yang, Liu, Dang, Fang, Tan, Zhao, Xu, Liu: Substance P attenuates hyperoxia‑induced lung injury in neonatal rats. in Molecular medicine reports 2014
Chicken Polyclonal Sonic Hedgehog Primary Antibody for IHC, IHC (p) - ABIN4893080
Lozito, Tuan: Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. in Development (Cambridge, England) 2016
Epithelial-mesenchymal transition programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.
the knockdown of Ihh (show IHH Antibodies) suppressed osteoblast growth and differentiation via a mechanism which may be associated with the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and OPG/RANKL (show TNFSF11 Antibodies) signaling pathways.
SHH signaling regulates the direction of cerebellar granule cells division.
The authors report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2 (show SHISA2 Antibodies), which inhibits the glycosylation and cell surface presentation of Frizzled3 (show FZD3 Antibodies) in rodent commissural axon growth cones.
ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta (show IL1B Antibodies) and IL-6 (show IL6 Antibodies) production through NF-kappaB (show NFKB1 Antibodies) and the Shh signaling pathway.
results indicate for the first time a possible mechanism involved in the crosstalk between fibroblasts and osteoblasts, as it was possible to observe trophic factors released by fibroblasts interfering decisively in osteoblast metabolism in a Shh-independent manner.
Importantly, Scube2 uncouples processing of Shh peptides from their lipid-mediated juxtamembrane positioning, and thereby explains the long-standing conundrum that N-terminally unlipidated Shh shows patterning activity in Scube2-expressing vertebrates
Shh signaling requires the coordinated activity of Sulf1 (show SULF1 Antibodies) and Sulf2 (show SULF2 Antibodies) in order to reach that threshold in the mouse ventral spinal cord
SHH-dependent activation of WNT (show WNT2 Antibodies) signaling supports regeneration of the cortex following long-term glucocorticoid treatment.
by acting upstream of Shh signaling pathway, Barhl2 (show BARHL2 Antibodies) plays a crucial role in patterning the progenitor domains and establishing the positional identities of progenitor cells in the diencephalon.
Shh and Gli1 (show GLI1 Antibodies) expression were associated with lymph node metastasis, TNM (show ODZ1 Antibodies) stage and tumor recurrence, suggesting Shh and Gli1 (show GLI1 Antibodies) protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma.
Case Report: medullablastoma with activated SHH expression.
NAFLD (show TSC2 Antibodies) progression is usually accompanied by activation of the Sonic hedgehog (SHH) pathway leading to fibrous buildup (scar tissue) and inflammation of the liver tissue. For the first time patients with holoprosencephaly, a disease caused by SHH signaling mutations, are shown to have increased liver steatosis independent of obesity.
Gpr161 (show GPR161 Antibodies) is a critical factor in the basal suppression machinery of Shh signaling, neural tube morphogenesis and closure. (Review)
Oncogenic activation of SHH is associated with Rubinstein-Taybi Syndrome and Medulloblastoma.
The results showed that Shh and Gli1 (show GLI1 Antibodies) were upregulated in prostate cancer tissues and were targeted by a phytogenic neoplastic compound carnosol.
Hh signaling activation might reflect aggressive tumoral behavior, since high epithelial GLI2 (show GLI2 Antibodies) expression positively correlates with a higher pathological Gleason score. Moreover, higher epithelial GLI3 (show GLI3 Antibodies) expression is an independent marker of a more favorable prognosis.
GPT2 (show GPT2 Antibodies) reduced alpha-ketoglutarate level in cells leading to the inhibition of proline hydroxylase 2 (PHD2 (show EGLN1 Antibodies)) activity involved in the regulation of HIF1alpha (show HIF1A Antibodies) stability. Accumulation of HIF1alpha (show HIF1A Antibodies), resulting from GPT2 (show GPT2 Antibodies)-alpha-ketoglutarate-PHD2 (show EGLN1 Antibodies) axis, constitutively activates sonic hedgehog (Shh) signaling pathway.
Results show SHH proteolysis is under the mechanism of Scube2 which is enriched at the surface of Shh-producing cells by heparan sulfate proteoglycans.
SHH-dependent E-ligase Midline1 (show MID1 Antibodies) regulates ubiquitin-mediated proteasomal degradation of Pax6 (show PAX6 Antibodies) during visual system development.
Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.
Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop (show SPOP Antibodies)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Antibodies)/Ci proteins in the Hh pathway.
Notch (show NOTCH1 Antibodies) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.
These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.
Connective tissue-specific expression of BMP-4 (show BMP4 Antibodies) mRNA is up-regulated by sonic hedgehog.
In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Antibodies) was expressed in the very anterior part of early lung epithelium.
Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal (show CAD Antibodies) boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.
The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.
Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis
study shows evolutionary alteration of a Ptch1 (show PTCH1 Antibodies) cis (show CISH Antibodies)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development
Mutation of hmgcs1 (show HMGCS1 Antibodies) had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (show GLI1 Antibodies), a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 Antibodies) mutants.
Shha/Smo is functionally dedicated to ray branching during fin regeneration.
Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.
Time-lapse imaging revealed that knockdown of miR (show MYLIP Antibodies)-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR (show MYLIP Antibodies)-219-mediated regulation of apical Par (show AFG3L2 Antibodies) proteins and Shh signaling.
Shh is not essential for the early activation of has2 (show HAS2 Antibodies), but supports proper chondrogenic differentiation.
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.
Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis
Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.
We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Antibodies)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Antibodies) morphants.
Pax6 (show PAX6 Antibodies) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
sonic hedgehog protein
, sonic hedgehog
, hemimelic extra toes
, short digits
, sonic hedgehog homolog
, sonic hedgehog protein A