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Browse our TTC8 Proteins (TTC8)

Full name:: Tetratricopeptide Repeat Domain 8 Proteins (TTC8)

On www.antibodies-online.com are 5 Tetratricopeptide Repeat Domain 8 (TTC8) Proteins from 3 different suppliers available. Additionally we are shipping TTC8 Antibodies (75) and and many more products for this protein. A total of 88 TTC8 products are currently listed.

Synonyms:: 0610012F22Rik, AV001447, BBS8, DKFZp459L2429, fk26c02, RP51, TTC8, wu:fk26c02, zgc:136718

list all proteins	Gene Name	GeneID	UniProt
	TTC8	123016	Q8TAM2
	TTC8	76260	Q8VD72
Rat TTC8	TTC8	299246
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TTC8 Proteins (TTC8) by Origin

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Relevant Pathways for TTC8 Proteins

Hedgehog Signaling

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Zebrafish Tetratricopeptide Repeat Domain 8 (TTC8) interaction partners

Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish

Human Tetratricopeptide Repeat Domain 8 (TTC8) interaction partners

Two novel mutations and three previously reported variants, identified in the present study, further extend the body of evidence implicating BBS6, BBS7, BBS8, and BBS10 in causing Bardet-Biedl Syndrome.
A splice-site mutation in a retina-specific exon of TTC8 causes nonsyndromic retinitis pigmentosa.
A homozygous null BBS8 mutation leads to Bardet-Biedl syndrome with randomization of left-right body axis symmetry, a known defect of the nodal cilium
small role of BBS7 and TTC8 in the overall mutational load of Bardet-Biedl syndrome patients

Mouse (Murine) Tetratricopeptide Repeat Domain 8 (TTC8) interaction partners

Loss of Bardet-Biedl Syndrome proteins (BBS) proteins Bbs6 and Bbs8 affects ciliated retinal pigment epithelium (RPE).
Loss of BBS8 led to changes in the distribution of photoreceptor axonemal proteins and hyper-acetylation of ciliary microtubules. Studies demonstrate the requirement for BBS8 in early development and elaboration of ciliated photoreceptor OS, explaining the need for BBS8 in normal vision.
Results show that BBS8 exon 2A is highly photoreceptor specific and the splicing enhancers within the flanking introns are sufficient to drive photoreceptor-specific inclusion of exon 2A and unrelated exons.
Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
Data suggest that loss of BBS8 leads to a dramatic and variable reduction in cilia, which alters the uniformity of responses in populations of olfactory sensory neurons expressing the same receptor, contributing to the observed axon-targeting defects.

TTC8 Protein Profile

Protein Summary

This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alternate transcriptional splice variants have been characterized.

Alternative names and synonyms associated with TTC8

tetratricopeptide repeat domain 8 (TTC8)
tetratricopeptide repeat domain 8 (ttc8)
tetratricopeptide repeat domain 8 (lpa_01174)
tetratricopeptide repeat domain 8 (Ttc8)

0610012F22Rik protein
AV001447 protein
BBS8 protein
DKFZp459L2429 protein
fk26c02 protein
RP51 protein
TTC8 protein
wu:fk26c02 protein
zgc:136718 protein

Protein level used designations for TTC8

tetratricopeptide repeat domain 8 , tetratricopeptide repeat protein 8 , tetratricopeptide repeat protein 8-like , Bardet-Biedl syndrome type 8 , TPR repeat protein 8 , bardet-Biedl syndrome 8 protein , bardet-Biedl syndrome 8 protein homolog

GENE ID	SPECIES
423401	Gallus gallus
467531	Pan troglodytes
615652	Bos taurus
678551	Danio rerio
694362	Macaca mulatta
733857	Xenopus (Silurana) tropicalis
9128627	Legionella pneumophila 2300/99 Alcoy
100172732	Pongo abelii
100415267	Callithrix jacchus
100471359	Ailuropoda melanoleuca
100590039	Nomascus leucogenys
123016	Homo sapiens
76260	Mus musculus
480413	Canis lupus familiaris
299246	Rattus norvegicus

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