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Human Polyclonal CLDN3 Primary Antibody for WB - ABIN2801966
Katahira, Sugiyama, Inoue, Horiguchi, Matsuda, Sugimoto: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. in The Journal of biological chemistry 1997
Show all 2 Pubmed References
Human Polyclonal CLDN3 Primary Antibody for ICC, IF - ABIN407632
He, Wei, Luo, Luo, Yang, Yu, Chen, Ma, Liang, Guo, Ye, Shi, Shen, Wang, Gong, He, Yang, Zhao, Song, Wei: Folate-linked lipoplexes for short hairpin RNA targeting claudin-3 delivery in ovarian cancer xenografts. in Journal of controlled release : official journal of the Controlled Release Society 2013
Data indicate that CDH11, ICAM1 (show ICAM1 Antibodies) and CLDN3 were overexpressed in tumors when compared to normal esophagus, normal gastric and non-dysplastic Barrett's.
Study provide first biochemically and clinically validated evidence to support a colorectal cancer-suppressive function of claudin-3 by serving as a conjoint rheostat for regulating Stat-3 (show STAT3 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-signaling.
These tumor samples express CD44 (show CD44 Antibodies) protein at low rather than high levels. There is no correlation between CLDN3 gene expression and protein expression in these CPTAC samples; hence, the claudin-low subtype defined by gene expression is not the same group of tumors as that defined by low expression of CLDN3 protein.
Increased expression of intestinal epithelial claudin-1 (show CLDN7 Antibodies) with downregulation of claudin-3 has been observed in intestinal inflammatory disorders.
Data show that the charge of Lys65 in claudin 1 (Cldn1 (show CLDN1 Antibodies)) and Glu158 in claudin 3 (Cldn3), and of Gln57 in claudin 5 (Cldn5 (show CLDN5 Antibodies)) are necessary for tight junction (TJ) strand formation.
Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 (show CLDN4 Antibodies) to nucleus in adenomas of the colon were detected for the first time. .
Reg (show EXTL3 Antibodies) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin (show OCLN Antibodies) proteolysis and claudin-3 transcription.
permeability barriers and affected cell morphology, proliferation, migration, AKT (show AKT1 Antibodies) signaling, and gene expression. When claudins are exogenously expressed, ARPE-19 more closely model native RPE (show RPE Antibodies).
localization of Cldn3, Cldn7 (show CLDN7 Antibodies) and Cldn10 (show CLDN10 Antibodies) proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
Reg (show KCNH2 Antibodies) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
claudin-3 and claudin-5 (show CLDN5 Antibodies) expression is increased by DHEAS (show SULT2A1 Antibodies) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
Cldn3(-/-) mice are fertile and show no Sertoli cell tight junction structural defects, even during the stages of Sertoli cell tight junction remodeling when preleptotene spermatocytes translocate from the basal to the adluminal compartment.
Study highlights a profound role for the choroid plexus in the pathogenesis of multiple sclerosis, and implies that CLDN3 may be regarded as a crucial and novel determinant of blood-cerebrospinal fluid barrier integrity
Seminiferous stage-specific expression and localization of claudin 3 during spermatogenesis regulate the progression of meiosis by promoting germ cell migration across the blood-testis barrier.
Claudin-3 expression in uterine luminal epithelium is stimulated by progesterone and suppressed by heparin-binding epidermal growth factor-like growth factor (show HBEGF Antibodies).
Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along alveolar ducts.
the results indicate that Grhl2 (show GRHL2 Antibodies) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 and Cldn4 (show CLDN4 Antibodies), as well as of Rab25 (show RAB25 Antibodies), which increases the Cldn4 (show CLDN4 Antibodies) protein and its localization at TJs
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
, CPE-R 2
, CPE-receptor 2
, Clostridium perfringens enterotoxin receptor 2
, ventral prostate.1 protein homolog
, ventral prostate.1-like protein
, clostridium perfringens enterotoxin receptor 2
, ventral prostate.1 protein
, integral membrane protein claudin-3
, tight junction-associated protein