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Human OAS1 Protein expressed in Wheat germ - ABIN1313295
Yin, Zhou, Dai: The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization. in Lung cancer (Amsterdam, Netherlands) 2012
Data indicate that the expression profiles of ISG15 (show ISG15 Proteins), MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 could be a useful diagnostic biomarker of gestation.
Studied diversity of OAS1 in hominoids (focus on chimpanzees) and found the OAS1 gene extremely polymorphic in Central African chimpanzee and exhibits levels of silent and replacement diversity much higher than neutral regions of the chimpanzee genome.
This study describes methylation patterns of CpG islands around the equine OAS1 locus in which polymorphic variants are associated with susceptibility to WNV infections
Mutations in equine OAS1 contribute to host susceptibility to West Nile encephalitis.
Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.
Activation of Oas1b gene expression by type I IFN requires only STAT2 (show STAT2 Proteins), not STAT1 (show STAT1 Proteins).
Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (show RNASEL Proteins) activation.
A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.
OAS1 rs2057778) genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Our results establish OAS1 as a risk locus for Sjogren's syndrome and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS (show SMOC1 Proteins) genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2 (show OAS2 Proteins)
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (show GBP1 Proteins), TLR3 (show TLR3 Proteins), OAS1, EIF2AK2 (show EIF2AK2 Proteins), HLA-E (show HLAE Proteins), IFI6 (show IFI6 Proteins), and STAT1 (show STAT1 Proteins), showed higher expression in the islet core compared with the peri (show PLIN1 Proteins)-islet area containing the surrounding immune cells
ELF-1 (show EFNA2 Proteins) binds an important duplicated GGAA cis (show CISH Proteins)-acting element at the OAS1 promoter and in cooperation with RB1 (show RB1 Proteins) and SP1 (show PSG1 Proteins) recruitment contributes to regulation in response to IFN stimulation.
Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases.
The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584).
Preliminary study suggests that OAS (show SMOC1 Proteins) gene cluster and CD209 (show CD209 Proteins) gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.
While both OAS1-p42 (show EPB42 Proteins) and p46 (show POLDIP3 Proteins) showed antiviral activity against Dengue irus 2, only OAS1-p42 (show EPB42 Proteins) presented anti-Dengue irus 1 activity.
No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM (show SERPINH1 Proteins)).
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.
The active sites of OAS (show SMOC1 Proteins) and CCA (show FBN2 Proteins) class I enzymes are highly conserved.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
2',5'-oligoadenylate synthetase 1, 40/46kDa
, 2'-5'-oligoadenylate synthase 1
, 2'-5'-oligoadenylate synthetase 1
, 2'-5' oligoadenylate synthetase 1
, 2',5'-oligoadenylate synthetase 1
, 2'-5'-oligoadenylate synthetase 1-like
, 2'-5'-oligoadenylate synthetase 1, 40/46kDa
, (2-5')oligo(A) synthase 1
, (2-5')oligo(A) synthase 1A
, (2-5')oligo(A) synthetase 1
, 2'-5' oligoadenylate synthetase 1G
, 2'-5'-oligoadenylate synthase 1A
, 2-5A synthase 1
, 2-5A synthase 1A
, 2-5A synthetase 1
, 25 oligoadenylate synthetase
, (2-5')oligo(A) synthase 1B
, (2-5')oligo(A) synthetase 1b
, 2',5'-oligoadenylate synthetase-like 1
, 2'-5'-oligoadenylate synthase 1B
, 2'-5'-oligoadenylate synthase-like protein 1
, 2'-5'-oligoadenylate synthetase-like protein 1
, 2-5A synthase 1B
, 2-5A synthetase 1B
, Flavivirus resistance
, inactive 2'-5'-oligoadenylate synthase 1B
, 2',5'-oligo A synthetase 1
, 2'-5' oligoadenylate synthetase 1 p48 isoform
, 2'-5' oligoadenylate synthetase 1 p52 isoform
, 2'-5'-oligoisoadenylate synthetase 1
, p46/p42 OAS
, 2-5-oligoadenylate synthetase 1
, 2'-5' oligoadenylate synthetase
, p42 OAS
, 2'-5' oligoadenylate synthetase 1z