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Human OAS1 Protein expressed in Wheat germ - ABIN1313295
Yin, Zhou, Dai: The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization. in Lung cancer (Amsterdam, Netherlands) 2012
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.
The active sites of OAS and CCA class I enzymes are highly conserved.
This study describes methylation patterns of CpG islands around the equine OAS1 locus in which polymorphic variants are associated with susceptibility to WNV infections
Mutations in equine OAS1 contribute to host susceptibility to West Nile encephalitis.
Studied diversity of OAS1 in hominoids (focus on chimpanzees) and found the OAS1 gene extremely polymorphic in Central African chimpanzee and exhibits levels of silent and replacement diversity much higher than neutral regions of the chimpanzee genome.
Children carrying OAS1 rs2660 AG genotype are more likely to have central nervous system involvement after enterovirus71 infection
functional variant in the OAS1 gene is associated with Sjogren's syndrome complicated with HBV infection
Data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.
OAS1 role in the genetic susceptibility to West Nile virus disease.[meta-analysis]
The G allele of rs10774671 was a significantly protective factor against tuberculosis and the genotype of GG differed significantly between tuberculosis patients and controls under the codominant model. rs1131454 G allele and GG genotype were protective against tuberculosis in the Chinese Han population
two additional de novo heterozygous missense variations of OAS1 in two unrelated simplex individuals also manifesting infantile-onset Pulmonary alveolar proteinosis with hypogammaglobulinemia.
Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.
Relative expression of OAS1 and Mx1 in patients with recurrent forms of Herpes simplex both during the acute stage and clinical remission did not differ significantly from that in healthy people after stimulation with IFN-alpha2b.
OAS1 rs2057778) genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Our results establish OAS1 as a risk locus for Sjogren's syndrome and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells
ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation.
Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases.
The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584).
Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.
While both OAS1-p42 and p46 showed antiviral activity against Dengue irus 2, only OAS1-p42 presented anti-Dengue irus 1 activity.
No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM).
along with TLR3, functions as a virus recognition receptor on mast cells activating the latent form of RNase L, leading to viral RNA degradation
our research shows that the OAS1 rs10774671 SNP is associated with CA16 susceptibility and is correlated with mild and severe HFMD.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
2',5'-oligoadenylate synthetase 1
, 2',5'-oligoadenylate synthetase 1, 40/46kDa
, 2'-5'-oligoadenylate synthase 1
, (2-5')oligo(A) synthase 1
, (2-5')oligo(A) synthetase 1
, 2'-5' oligoadenylate synthetase
, 2-5A synthase 1
, 2-5A synthetase 1
, p42 OAS
, 2-5-oligoadenylate synthetase 1
, 2'-5' oligoadenylate synthetase 1
, 2',5'-oligo A synthetase 1
, 2'-5' oligoadenylate synthetase 1 p48 isoform
, 2'-5' oligoadenylate synthetase 1 p52 isoform
, 2'-5'-oligoisoadenylate synthetase 1
, p46/p42 OAS
, 2'-5'-oligoadenylate synthetase 1-like
, 2'-5'-oligoadenylate synthetase 1, 40/46kDa
, LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1