Protein Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with OAS1

• 2',5'-oligoadenylate synthetase 1 (OAS1) antibody
• 2'-5'-oligoadenylate synthetase 1 (OAS1) antibody
• 2'-5'-oligoadenylate synthetase 1 (Oas1) antibody

• IFI-4 antibody
• OAS1 antibody
• OIAS antibody
• OIASI antibody

Protein level used designations for OAS1

2',5'-oligoadenylate synthetase 1 , 2',5'-oligoadenylate synthetase 1, 40/46kDa , 2'-5'-oligoadenylate synthase 1 , (2-5')oligo(A) synthase 1 , (2-5')oligo(A) synthetase 1 , 2'-5' oligoadenylate synthetase , 2-5A synthase 1 , 2-5A synthetase 1 , p42 OAS , 2-5-oligoadenylate synthetase 1 , 2'-5' oligoadenylate synthetase 1 , 2',5'-oligo A synthetase 1 , 2'-5' oligoadenylate synthetase 1 p48 isoform , 2'-5' oligoadenylate synthetase 1 p52 isoform , 2'-5'-oligoisoadenylate synthetase 1 , E18/E16 , p46/p42 OAS , 2'-5'-oligoadenylate synthetase 1-like , 2'-5'-oligoadenylate synthetase 1, 40/46kDa , LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1