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anti-Human CGRP Antibodies:
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Bullfrog (Rana catesbeiana) Polyclonal CGRP Primary Antibody for IEM, ICC - ABIN617907
Abdel-Rahman, Collins, Cowen, Rustin: Immunohistochemical, morphological and functional changes in the peripheral sudomotor neuro-effector system in elderly people. in Journal of the autonomic nervous system 1992
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Emu (Dromaius novaehollandiae) Polyclonal CGRP Primary Antibody for IHC (fro), IF - ABIN2472952
Pritz, Stritzel: Reptilian dorsal column nucleus lacks GAD immunoreactive neurons. in Brain research 1990
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Human Polyclonal CGRP Primary Antibody for IF (p), IHC (p) - ABIN728218
Tu, Li, Peng, Hu, Liu, Kong, Liu, Gao, Xu, Xu, Qiu, Fan, Zhu, Yu, Zheng, Wu, Peng, Song, Wu, Liang: P2X(7) inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury. in Brain research bulletin 2013
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Human Monoclonal CGRP Primary Antibody for ELISA, IHC - ABIN449440
Kondo, Oshima, Koseki, Hattori, Kase, Tomita, Fukui, Watari, Miwa: Effect of rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2014
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Human Polyclonal CGRP Primary Antibody for IHC (fro), IF - ABIN115755
Schulze, Witt, Fink, Hofer, Funk: Immunohistochemical detection of human skin nerve fibers. in Acta histochemica 1997
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Human Polyclonal CGRP Primary Antibody for IF, IHC - ABIN504718
Por, Choi, Lund: Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea. in Current eye research 2016
The significance of the presence of immunoreactive isoforms and fragments of calcitonin with different stability in patients with medullary thyroid carcinoma is unclear.
PCT serum level is associated with catheter-related bloodstream infection in severe burn patients.
PCT use among sepsis discharges increased six-fold while lactate and CRP use remained unchanged. PCT use was associated with decreased odds of in-hospital mortality but increased hospital costs per day.
Findings show that a combination of CRP, PCT, TRAIL and IP-10 can identify bacterial infections with higher accuracy than single biomarkers and combinations of a single bacterial biomarkers combined with TRAIL and IP-10.
CGRP plays a role in human headache pathophysiology.
this study did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary total hip arthroplasty in a Western European group.
Elevated PCT concentration may serve as a biomarker of worse outcome in patients with chronic heart failure with reduced ejection fraction.
CGRP expression in the infrapatellar fat pad of knee osteoarthritis patients is regulated by the COX-2/mPGES-1/PGE2 pathway.
PCT may not be sufficiently used as a sole marker of sepsis in neonates compared to CRP. PCT in conjunction with CRP and other tests for septic screen can aid in better diagnosis of neonatal sepsis.
Levels of CRP and PCT in CSF did not present greater accuracy in differentiating bacterial from viral meningitis compared to serum levels.
Medullary thyroid carcinoma (MTC) was histologically confirmed in all patients with positive procalcitonin (PCT) but not found in patients with negative PCT. Serum PCT levels were significantly higher in patients with MTC than in those without.
This is the largest data set evaluating PCT in neonatal and pediatric patients on extracorporeal membrane oxygenation (ECMO). A PCT value of 0.5 ng/mL had the most utility for determining the absence or presence of a bacterial infection in the setting of ECMO with a high sensitivity and negative predictive values.
The data shows a subgroup of patients 17/34 (50%) have either elevated PCT or CRP levels. This study is the first to report PCT values in antipsychotic drug-free patients with schizophrenia.
Procalcitonin is reliable in discriminating medullary thyroid carcinoma patients with active disease from those with no evidence of disease.
This retrospective cohort study aimed to identify the early postoperative kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in children undergoing tetralogy of Fallot (ToF) correction.
PCT could be a promising marker of clinical deterioration to septic shock in acute cholangitis. Therefore, PCT might be used as a decision-supporting biomarker for urgent biliary decompression.
this study shows that pre-eclampsia affects procalcitonin production in placental tissue
peripheral concentration of procalcitonin (both immediate and average levels) might be an independent predictor for prognosis in myocardial infarction patients.
Patients with procalcitonin (PCT) above 0.25 mug/L are unlikely to have a unique diagnosis of flu.
The cut-off point of procalcitonin level for diagnosing sepsis in the meta-static solid tumor was higher compared to the standard value.
This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.
Calcitonin is a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene.
Calcitonin gene-related peptide is known to increase miniature endplate potentials.
We reported here for the first time that CGRP inhibited the cardiac fibroblasts senescence and senescence-associated secretory phenotype in cardiac fibrosis via up-regulating the klotho expression. On the basis of our previous study, the present study further determined the protective role of CGRP in heart, with consequent therapeutic implications for heart failure.
activation of TRPV3 also plays a critical role in modulation of heat-induced vasodilation via a controlled release of CGRP in response to moderate heating of the skin.
CGRPalpha from within TRPV1-cre population plays an important role in visceral nociception but less so in somatic nociception.
Report a novel positive function of mm9_circ_009056 during osteogenesis in regulating BMP7 through miR-22-3p. Furthermore, the expression of mm9_circ_009056 was up-regulated in CGRP-induced cells, whereas miR-22-3p was decreased.
Hepatic PCT expression is upregulated in ALF. Hepatic macrophages but not hepatocytes are the cell source of hepatic PCT expression.
alphaCGRP overexpression causes an increase in thermal reaction and downregulation of the cardiovascular system, presumably due in increased levels of alphaCGRP.
Glucagon-like peptide (GLP)-1 modulates epithelial ion transport indirectly by activating calcitonin gene-related peptide (CGRP)-containing submucosal enteric neurons in the mouse colon. This GLP-1-CGRP response was area-specific and could potentially contribute to the diarrheal side effect of certain GLP-1 receptor therapeutics.
This study demonstrated that the expression patterns of the calcitonin-related polypeptide alpha and tyrosine hydroxylase formed opposing gradients, with tyrosine hydroxylase being preferentially expressed in apical and calcitonin-related polypeptide alpha in basal type II afferent neurons, indicating heterogeneity among type II afferent neurons.
CGRP-1 is essential for pain-associated plasticity in the central amygdala.
These results suggest that neuronal TRPV1 signaling in periodontal tissue is crucial for the regulation of osteoclastogenesis via the neuropeptide CGRP.
alphaCGRP played a synergic role in angiogenesis and osseointegration, partly as a consequence of its vasodilative activity.
results indicate that CGRP regulates macrophage polarization and inhibits inflammation in murine macrophages.
The results indicate a central role of neuroendocrine peptide aminoprocalcitonin (NPCT) in Alzheimer disease pathogenesis and suggest NPCT as a potential biomarker and therapeutic target.
In addition to its actions in the cardiovascular system, endogenous CGRP is a key regulator of metabolism and energy homeostasis in vivo.
findings establish CGRP neurons in the parabrachial nucleus as key mediators of cancer-induced appetite suppression and associated behavioral changes.
These results identify an important, possibly dual role of CGRP in Amyotrophic lateral sclerosis pathogenesis.
functional inactivation of CGRP neurons markedly increases meal size, with meal frequency being reduced in a compensatory manner, and renders mice insensitive to the anorexic effects of meal-related satiety peptides.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
The abundance of mRNA of CGRP and bone matrix markers (Col I, Col II, and OPN) was low at P5 in the tibia. These differences in CGRP and other mRNAs may induce a different manner of ossification between the mandible and tibia. Therefore, a time lag of ossification occurs between the mandible and tibia during foetal development.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
The reciprocal changes in SST and histamine secretion in gastric Helicobacter infection were due to release of CGRP from sensory neurons.
Substance P and CGRP correlate with the occurrence and development of allergic rhinitis.
Results showed an increase in procalcitonin concentration in horses with systemic inflammatory response syndrome as previously reported in humans and dogs.
CGRP acts via its receptor expressed by Langerhans cell (LC) and interferes with multiple steps of LC-mediated HIV-1 transmission.[CGRP]
These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis.
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
, calcitonin 1
, calcitonin gene-related peptide I
, calcitonin/calcitonin-related polypeptide, alpha
, calcitonin gene-related peptide
, calcitonin-related polypeptide alpha
, calcitonin gene-related peptide 2
, calcitonin-related polypeptide 3
, Calcitonin gene-related peptide
, alpha CGRP
, calcitonin gene-related peptide 1
, calcitonin/alpha CGRP
, calcitonin gene related peptide I