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Human FNDC5 ELISA Kit for Sandwich ELISA - ABIN1117917
Choi, Kim, Bae, Seo, Jeong, Lee, Kim, Lee, Park: Serum irisin levels in new-onset type 2 diabetes. in Diabetes research and clinical practice 2013
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Mouse (Murine) FNDC5 ELISA Kit for Sandwich ELISA - ABIN1874468
Rachid, Penna-de-Carvalho, Bringhenti, Aguila, Mandarim-de-Lacerda, Souza-Mello: Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice. in Molecular and cellular endocrinology 2015
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Human FNDC5 ELISA Kit - ABIN2039309
Li, Yang, Zhou, Fang, Hu, Zhu, Wang, Liu, Li, Liu, Yang, Li: Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome. in The Journal of clinical endocrinology and metabolism 2015
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Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
irisin was significantly higher in obese than in control children, and was inversely correlated with Acrp30 and high molecular weight (HMW) oligomers; inverse correlation between Irisin and Acrp30 and, more significantly, between Irisin and HMW oligomers suggests that the two cytokines are closely connected
Irisin is an oxidative stress marker and a metabolic protective hormone.
Mild cold exposure increased vasoconstriction with a drop in in-the-ear temperature and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering
Activation of the nuclear receptor constitutive androstane receptor (show NR1I3 ELISA Kits) (CAR) induced FNDC5 mRNA expression in the liver.
HCC (show FAM126A ELISA Kits)-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage.
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS ELISA Kits) biosynthesis and glucose-stimulated insulin (show INS ELISA Kits) secretion, and beta-cell apoptosis are reported.
Irisin regulates the number and function of endothelial progenitor cells via the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/eNOS (show NOS3 ELISA Kits) pathway in mouse model of diabetes mellitus.
there is a correlation between sport performance, insulin (show INS ELISA Kits) sensitivity, and irisin levels
results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 ELISA Kits)-NLRP3 (show NLRP3 ELISA Kits) inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.
These data indicate that increased irisin levels may have protective roles in liver cancer cells through partial activation of the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD (show TSC2 ELISA Kits) without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 ELISA Kits)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 ELISA Kits) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 ELISA Kits)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 ELISA Kits)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 ELISA Kits).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein