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anti-Human GNRH1 Antibodies:
anti-Mouse (Murine) GNRH1 Antibodies:
anti-Rat (Rattus) GNRH1 Antibodies:
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Atlantic Hagfish (Myxine glutinosa) Polyclonal GNRH1 Primary Antibody for IEM, ICC - ABIN617888
Masucci, DAniello, Iela, Ciarcia, Rastogi: Immunohistochemical demonstration of the presence and localization of diverse molecular forms of gonadotropin-releasing hormone in the lizard (Podarcis s. sicula) brain. in General and comparative endocrinology 1992
Show all 77 Pubmed References
Goat Polyclonal GNRH1 Primary Antibody for IF (cc), IF (p) - ABIN668841
Liu, Chang, Sun, Zhu, Pu, Zhu, Wang, Xu: Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells. in Molecular pharmaceutics 2014
Amphibian Polyclonal GNRH1 Primary Antibody for ICC, IF - ABIN152665
Pandolfi, Hoffmann, Schoeller, Gorman, Mellon: Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. in Molecular neurobiology 2018
High expression of LHRH is associated with ovarian cancer.
Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.
High LHRH expression is associated with sarcomas of bone and soft tissue.
mutations in the region encoding the decapeptide associated with complete Idiopathic hypogonadotropic hypogonadism
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression.
analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells
our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy.
Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review)
Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.
No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes
Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice.
Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist.
GnRH agonists fail to increase Bax expression and do not potentiate the cytotoxic activity of docetaxel
GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma.
This review will summarize the current understanding of the mechanisms by which PACAP modulates gonadotrope function, with a focus on interactions with GnRH.
Current research efforts aim to discover the mechanisms responsible for the decoding of the GnRH pulse signal by the gonadotrope.
GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells.
This review summarizes the mechanisms used by glial cells to control GnRH neuronal ativity and secretion.
R31C GNRH1 is the only missense mutation that was identified in a CpG islet in nine congenital hypogonadotropic hypogonadism subjects from four unrelated families, giving evidence for a putative ''hot spot''.
GnRH excitability is upregulated during positive feedback, perhaps driving increased neural firing rate at this time
hypogonadism driven by decreased hypothalamic GnRH may be a component of obesity-related infertility.
the protein kinase c enzymes involved in GnRH stimulated mitogen activated protein kinase phosphorylation in gonadotrope derived cells, were identified.
In immature GN11 cells, VAX1 and cFOS enhance GnRH expression, whereas VAX1 and cFOS have a repressive role in the mature GT1-7 cells.
This work provides new findings inglucocorticoid (GC) field by bringing novel understanding on how GR integrates plasma membrane, allowing GC membrane-initiated signaling that differs in presence of GnRH to disrupt GnRH-dependent signaling and luteinizing hormone secretion.
Six3 is haploinsufficient for main olfactory epithelium development, GnRH neuron migration, and fertility.
Data (including data from studies in transgenic mice) suggest that Crh alters Gnrh neuron activity and that estradiol is required for Crh to exert both stimulatory and inhibitory effects on Gnrh neurons. (Crh = corticotropin-releasing hormone; Gnrh = gonadotropin releasing hormone)
Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit)
The studies in this manuscript describe specific histone modifications on the enhancer and promoter of the mouse GnRH (mGnRH) gene induced by kisspeptin in GnRH neuronal cell lines.
Nesfatin-1 increased Gnrh expression in hypothalamic and pituitary cells.
GnRH-E1 RNA is an inducer of Gnrh1 gene expression that may play an important role in the development and maturation of GnRH neurons
tet2 activity in GnRH neurons has influence over the neuroendocrine control of male reproductive function
Neurons in the hypothalamus produce Kiss1 and can synchronize their activity and activate GnRH neurons thus coordinating reproduction and fertility.
GnRH stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb gene induction.
DHA and palmitate increase Gnrh enhancer-derived RNA levels.
findings suggest that GnRH is necessary for constitutive ANXA5 expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types
In this study, we investigate the mechanism by which VAX1 controls fertility finding that VAX1 is required for maintenance of Gnrh1 gene expression and deletion of Vax1 from GnRH neurons leads to complete infertility.
RALDH and RA might not be directly involved in the reduction of GnRH expression induced by TSA, however these substances could be a novel regulator of GnRH.
The profound effect of Sirt1 on the hormonal status of Sirt1(-/-) mice, mediated via defective GnRH neuronal migration, links energy metabolism directly to the hypogonadal state.
neural circuits between kisspeptin and GnRH neurons in the male mouse arcuate nucleus of the hypothalamus established before birth
Guinea pig GnRH is predominantly present in the brain and has a lower in vivo luteinizaing hormone (LH)-releasing activity than Gnrh of the rat.
findings report the changes in inhibin-alpha subunit gene expression in the corpus luteum is regulated by LH; results suggest a possible multiple crosstalk of Wnt, cAMP, and SF-1 in the regulation of luteal inhibin secretion
Posterior hypothalamic lesion animals had elevated LHRH levels and higher evening glutamate levels after lesions, whereas LHRH changes did not occur in sham/controls until later.
Estradiol(E2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E2 appears to be mediated, in part, through GPR30.
These results suggest that social hierarchy regulates the expression of GnRH1, GnRH3, and Kiss1 without affecting 11-ketotestosterone level in male medaka.
Study detected several subpopulations of GnRH1 and GnRH3 neurons classified by their projection and distribution patterns using gnrh1:EGFP medaka and gnrh3:EGFP medaka
A single nucleotide polymorphism in the gonadotropin-releasing hormone gene was found to have no significant association with sperm quality in Chinese Holsein bulls.
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene.
GnRH-associated peptide 1
, gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
, luliberin I
, progonadoliberin I
, prolactin release-inhibiting factor
, gonadotropin releasing hormone 2
, luteinizing hormone-releasing hormone I
, gonadotropin releasing hormone 1
, luteinizing hormone-releasing hormone
, chicken gonadotrophin releasing hormone-I
, gonadotrophin-releasing hormone I
, gonadotropin-releasing hormone associated peptide
, progonadoliberin-1 preproprotein
, Progonadoliberin I
, luliberin i
, luteinizing hormone
, luteinizing-releasing hormone
, Medaka-type gonadotropin-releasing hormone
, gonadotropin-releasing hormone
, medaka-type gonadotropin-releasing hormone
, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)