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downregulation of ADM might be an adaptive attempt of neurons to mitigate microtubule disruption.
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MR-proADM may be able to serve as a biomarker of endometriosis, but it is unknown whether elevated MR-proADM levels are secondary to the estrogenic and inflammatory properties of endometriosis or an inciting pathogenic factor.
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Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans.
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ADM was an upstream molecule of HIF-1alpha/VEGF and it promoted angiogenesis through upregulating HIF-1alpha/VEGF in epithelial ovarian cancer.
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Identifying a marker(adrenomedullin) for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor
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High ADM expression is associated with lymph node metastasis in oral and oropharyngeal squamous cell carcinoma.
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High expression of ADM is correlated with sunitinib-resistant renal cell carcinoma.
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results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC.
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Report an association of elevated ProADM blood levels and 10-year all-cause mortality in a primary care cohort with respiratory tract infections.
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These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling.
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our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation
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promotes the proliferation and inhibits apoptosis of dental pulp stem cells
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MR-proADM but not copeptin was significantly associated with prognosis of COPD exacerbations at 30 days.
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Findings indicate the importance of cancer-associated fibroblasts (CAFs)-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis.
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This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases.
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Admission MR-proADM concentrations provide strong prognostic information in patients with acute HF, but modest diagnostic information in patients with acute dyspnea.
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Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
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SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .
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MR-proADM showed a significant association with BP reduction after 6 months
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Elevated plasma level of MR-proADM, determined 24 h after diagnosis of Cardiogenic shock could be a predictor of in-hospital mortality in patients with acute myocardial infarction complicated by CS.
