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anti-Rat (Rattus) Adrenomedullin Antibodies:
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downregulation of ADM might be an adaptive attempt of neurons to mitigate microtubule disruption.
MR-proADM may be able to serve as a biomarker of endometriosis, but it is unknown whether elevated MR-proADM levels are secondary to the estrogenic and inflammatory properties of endometriosis or an inciting pathogenic factor.
Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans.
ADM was an upstream molecule of HIF-1alpha/VEGF and it promoted angiogenesis through upregulating HIF-1alpha/VEGF in epithelial ovarian cancer.
Identifying a marker(adrenomedullin) for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor
High ADM expression is associated with lymph node metastasis in oral and oropharyngeal squamous cell carcinoma.
High expression of ADM is correlated with sunitinib-resistant renal cell carcinoma.
results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC.
Report an association of elevated ProADM blood levels and 10-year all-cause mortality in a primary care cohort with respiratory tract infections.
These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling.
our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation
promotes the proliferation and inhibits apoptosis of dental pulp stem cells
MR-proADM but not copeptin was significantly associated with prognosis of COPD exacerbations at 30 days.
Findings indicate the importance of cancer-associated fibroblasts (CAFs)-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis.
This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases.
Admission MR-proADM concentrations provide strong prognostic information in patients with acute HF, but modest diagnostic information in patients with acute dyspnea.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .
MR-proADM showed a significant association with BP reduction after 6 months
Elevated plasma level of MR-proADM, determined 24 h after diagnosis of Cardiogenic shock could be a predictor of in-hospital mortality in patients with acute myocardial infarction complicated by CS.
AM is an important regulator of endothelial cell function, angiogenesis, tumorigenesis, and brain response to ischemia.
The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases.
Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.
the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery.
vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin
It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.
Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.
These results indicate the AM-RAMP2 system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
It is a vasodiation factor and a essential factor for angiogenesis.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase probably by suppressing the local renin-angiotensin system.
Hypoxia upregulates expression of the Notch ligand Dll4 and increases Notch signaling in a process requiring the vasoactive hormone adrenomedullin.
Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis.
ADM signaling is involved in laser-induced CNV formation, because both an ADM antagonist and ADM mAb significantly inhibited it.
Endogenous adrenomedullin is a key factor in secondary lymphedema pathogenesis and provides experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder.
Fetal adrenomedullin, acting through calcitonin receptor-like receptor, serves as a trophoblast-derived factor critical for fetal placental vascularization.
The AM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood.
Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in beta cells and mice.
Studied adrenomedullin's (ADM) role in oviductal fluid flow in cattle.
Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells.
The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells.
Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide receptor; not adrenomedullin receptor).
adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK-dependent manner
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.