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CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state.
This study links Cplx3 expression with synapse and circuit function in a specific retinal pathway and reveals a role for asynchronous release in circuit gain control.
The findings of this study reveal a suppressing action of Cplx3/4 on tonic neurotransmitter release, a facilitating action on evoked release, and a regulatory role of Cplx3/4 in the adaptation-dependent availability of synaptic vesicles at mouse photoreceptor ribbon synapses.
This study demonistrated that Cplx3-positive cells are generated during the 2-day peak of subplate neurogenesis (E11.5-E12.5). survive preferentially after the first postnatal week compared with other subplate neurons.
The lack of Cplx 3 and Cplx 4 differentially impacts the ON and OFF pathways in the retina is corroborated by localization studies of Cplx 3 and Cplx 4 in the retina.
The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons.(cOMPLEXIN III, MOUSE)
Results show that complexin 3 and complexin 4 are essential regulators of transmitter release at retinal ribbon synapses.
Positively regulates a late step in synaptic vesicle exocytosis (By similarity).
, Complexin III
, CPX III
, complexin III
, lectin, mannose-binding, 1 like