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anti-Human Interleukin 6 Antibodies:
anti-Mouse (Murine) Interleukin 6 Antibodies:
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Human Monoclonal Interleukin 6 Primary Antibody for FACS - ABIN1383944
Lu, Brochier, Wijdenes, Brailly, Bataille, Klein: High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. in European journal of immunology 1992
Show all 60 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042620
Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. in Journal of cellular biochemistry 2011
Show all 19 Pubmed References
Rat (Rattus) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042526
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 17 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3043090
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
Show all 17 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for ELISA, WB - ABIN3043248
Shi, Song, Zhang, Li, Li: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. in Experimental and therapeutic medicine 2013
Show all 17 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042806
Chen, Zhao, Wu, Zou, Luo, Li, Xie, Liang: The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice. in International journal of clinical and experimental pathology 2015
Show all 10 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for ICC, IF - ABIN269335
Bottino, Balamurugan, Tse, Thirunavukkarasu, Ge, Profozich, Milton, Ziegenfuss, Trucco, Piganelli: Response of human islets to isolation stress and the effect of antioxidant treatment. in Diabetes 2004
Show all 12 Pubmed References
Human Monoclonal Interleukin 6 Primary Antibody for CyTOF, FACS - ABIN4900155
Maneechotesuwan, Wamanuttajinda, Kasetsinsombat, Huabprasert, Yaikwawong, Barnes, Wongkajornsilp: Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. in The Journal of allergy and clinical immunology 2009
Show all 8 Pubmed References
Human Monoclonal Interleukin 6 Primary Antibody for CyTOF, FACS - ABIN4900156
Rodier, Coppé, Patil, Hoeijmakers, Muñoz, Raza, Freund, Campeau, Davalos, Campisi: Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. in Nature cell biology 2009
Show all 8 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for IF (p), IHC (p) - ABIN728083
Sun, Zeng, Cao, Song, Zhang, Liu: Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue. in BioMed research international 2015
Show all 7 Pubmed References
Results show that interleukin 6 (IL6) promotes oval cell proliferation and liver regeneration, while tumor necrosis factor alpha (TNFalpha (show TNF Antibodies)) and TNF (show TNF Antibodies) receptor-1(TNFR1 (show TNFRSF1A Antibodies)) do not affect this process.
IL-6 role in the bone corticalization
thrombin (show F2 Antibodies) is increased in a mouse model of cancer cachexia in a partially interleukin-6 dependent manner
results suggest that the intrinsic microglial clock modulates the inflammatory response, including the positive regulation of IL-6 expression in a particular pathological situation in the brain
IL-2 (show IL2 Antibodies) and IL-6 work together to enhance influenza-specific CD8 (show CD8A Antibodies) T cell generation responding to live influenza virus in aged mice and humans
These results show that the systemic IL-6 effector pathway mediates bone deterioration induced by repetitive inhalant ODE exposures through an effect on osteoclasts, but a positive role for IL-6 in the airway was not demonstrated. IL-6 might be an important link in explaining the lung-bone inflammatory axis.
skeletal muscle IL-6 contributes to reestablishing metabolic homeostasis during recovery from exercise by regulating WAT and skeletal muscle metabolism
pattern of STAT (show STAT1 Antibodies) indicates that possibly TGF-beta (show TGFB1 Antibodies) and IL-6 play a crucial role in differentiation of DCs subsets and Treg/Th17 imbalance during experimental cerebral malaria (ECM (show MMRN1 Antibodies)).
IL-6 promotes CD4 (show CD4 Antibodies)(+) T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production.
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha (show TNF Antibodies) mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta (show IL1B Antibodies) and IL-6 mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
The dual role of IL-6 in senescence and tumorigenesis is well represented in pituitary tumor development, as it has been demonstrated that effects of paracrine IL-6 may allow initial pituitary cell growth, whereas autocrine IL-6 in the same tumor triggers senescence and restrains aggressive growth and malignant transformation. (Review)
study focused on IL-6 and activation of its receptors gp80 (show CLU Antibodies) and gp130 (show IL6ST Antibodies) in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (show FBXL15 Antibodies) Kit, Unifast, and Duralay on control of inflammation
lnc-DILC mediates the crosstalk between TNF-alpha (show TNF Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling and autocrine IL-6/STAT3 (show STAT3 Antibodies) cascade and connects hepatic inflammation with Lliver cancer stem cells expansion.
IL-6, IL-8 (show IL8 Antibodies), and IL-10 (show IL10 Antibodies) circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections.
In conclusion, the analyzed IL1A (show IL1A Antibodies) -889 C>T, IL1B (show IL1B Antibodies) +3954 C>T, and IL6 -174 G>C polymorphisms may be associated with the occurrence and development of human cytomegalovirus infection among studied patients.
IL-6 Polymorphism and Susceptibility to Keloid Formation in a Japanese Population
Acquired lapatinib-resistant HER2 (show ERBB2 Antibodies)-positive breast cancer cells had elevated IL-6, and that elevated IL-6 maintained the stemness population and property within these resistant cells through the activation of STAT3 (show STAT3 Antibodies).
In this review, we describe the basic biology of both cytokines and summarize the current knowledge how proteases control and shape the trans-signaling pathways of the two cytokines.We will further highlight how the underlying molecular mechanisms can be used to design specific inhibitors that block trans, but not classic signaling of IL-11 (show IL11 Antibodies) and IL-6
Review/Meta-analysis: circulating levels of CRP (show CRP Antibodies), IL-6 and TNF-alpha (show TNF Antibodies) might be not useful biomarkers for identifying colorectal adenoma risk.
Lipid apheresis suppresses the expression of IL-1alpha, IL-6 and TNF-alpha (show TNF Antibodies) mRNA in patients with dyslipidaemias.
STA3 (show ARHGEF3 Antibodies) facilitates TLR4 (show TLR4 Antibodies)-dependent IL-6 and IL-8 (show IL8 Antibodies) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Testicular IL-1 alpha (show IL1A Antibodies) and IL-1 beta (show IL1B Antibodies) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Antibodies) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Antibodies), iNOS (show NOS2 Antibodies), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Antibodies) was unaffected.[IL-6, IL-12 (show IL12A Antibodies)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Antibodies) and IL-6/sIL (show STIL Antibodies)-6R in causing proteoglycan (show Vcan Antibodies) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Antibodies) and IL-6 in rabbit cornea cells.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Antibodies)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Antibodies), IL-10 (show IL10 Antibodies), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Antibodies) (signal transducer/activator of transcription (show STAT1 Antibodies) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Antibodies) expression/phosphorylation).
LIF (show LIF Antibodies) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (show EDN1 Antibodies), and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP (show BNC2 Antibodies), ICAM-1 (show ICAM1 Antibodies), TNF-alpha (show TNF Antibodies), VCAM-1 (show VCAM1 Antibodies) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Antibodies) signaling pathway transactivator beta-catenin (show CTNNB1 Antibodies), induced expression of inhibitors of the Wnt (show WNT2 Antibodies) pathway, and increased expression of GDF-5 (show GDF5 Antibodies).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Antibodies) activation and that this effect can be modulated by A2AAR (show ADORA2A Antibodies)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Antibodies) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Antibodies)), are potent inducers of IL-1beta (show IL1B Antibodies) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Antibodies).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)