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anti-Human Interleukin 6 Antibodies:
anti-Mouse (Murine) Interleukin 6 Antibodies:
anti-Rat (Rattus) Interleukin 6 Antibodies:
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Human Monoclonal Interleukin 6 Primary Antibody for FACS - ABIN1383944
Lu, Brochier, Wijdenes, Brailly, Bataille, Klein: High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. in European journal of immunology 1992
Show all 60 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042620
Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. in Journal of cellular biochemistry 2011
Show all 29 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for ELISA, WB - ABIN3043248
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 27 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3043090
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
Show all 27 Pubmed References
Rat (Rattus) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042526
Shi, Song, Zhang, Li, Li: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. in Experimental and therapeutic medicine 2013
Show all 27 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042806
Chen, Zhao, Wu, Zou, Luo, Li, Xie, Liang: The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice. in International journal of clinical and experimental pathology 2015
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Human Polyclonal Interleukin 6 Primary Antibody for ICC, IF - ABIN269335
Bottino, Balamurugan, Tse, Thirunavukkarasu, Ge, Profozich, Milton, Ziegenfuss, Trucco, Piganelli: Response of human islets to isolation stress and the effect of antioxidant treatment. in Diabetes 2004
Show all 23 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for IF (p), IHC (p) - ABIN728083
Sun, Zeng, Cao, Song, Zhang, Liu: Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue. in BioMed research international 2015
Show all 14 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for ELISA, WB - ABIN5693120
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. in Journal of experimental & clinical cancer research : CR 2010
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Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for IF (p), IHC (p) - ABIN739385
Li, Dan, Nie, Hu, Gesang, Bianba, Ze, Ciren: CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts. in Molecular medicine reports 2015
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IL-6 levels was associated to worst course of rheumatoid arthritis.
Role of IL-6/RORC/IL-22 axis in driving Th17 pathway mediated immunopathogenesis of schizophrenia.
Chronic kidney disease did not significantly alter IL-6 genotypes, but IL-6 gene polymorphism had a significant effect on serum erythropoietin levels and a nonsignificant effect on Hb levels.
The results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased osteoporosis risk in post-menopausal women.
After uncomplicated total knee arthroplasty, IL-6 showed a sharp rise to peak at 12 hours, then fell rapidly to near baseline levels by 4 days and returned to the baseline level at 2 weeks.
The mean level of interleukin-6 was 49.65+/-3.04 in pregnant women after assisted reproductive procedures and 104.14+/-76.03 in non-pregnant women, with significant inverse correlation with endometrial thickness.
IL-1beta; IL-6 and IL-8 causes hypercoagulation.
The authors were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by Interleukine-6 (IL-6), Activin-A and Granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation.
Acute exercise in the heat increased IL-6.
Study found that IL-6, GP130, IGF-1 and IGF-1R were highly expressed in non-small cell lung cancer (NSCLC) and there was the correlation between GP130, IGF-1, and IGF-1R. Co-stimulation of IL-6 and IGF-1 resulted in significantly enhanced cell proliferation, invasion, and apoptosis of NSCLC cells. This experiment revealed that IL-6 and IGF-1 can synergistically promote the progression of NSCLC.
There was a longitudinal and direct association between adiposity and IL-6 and CRP, and an inverse association with adiponectin at 22years.
findings suggest that IL-6 -174G>C and -572G>C polymorphisms may serve as potential genetic markers of coronary artery disease
during inflammation, IFN-gamma regulates IL-6/STAT3 signaling in intestinal epithelial cells in the colonic mucosa
Priming of cells with Poly (I:C) LMW reduced subsequent IL-6 secretion upon stimulation with TLR 2-4 agonists. Poly (I:C) LMW exerts a potent pro-inflammatory effect on HNECs and reduces a subsequent immune activation by TLR agonists
our results indicate that GRSF1 helps preserve mitochondrial homeostasis, in turn preventing oxidative DNA damage and the activation of mTOR and NF-kappaB, and suppressing a transcriptional pro-inflammatory program leading to increased IL6 production.
Results suggest that autocrine interleukin 6 (IL-6) signaling may occur intracellularly.
These results indicate that functional lactic acid bacteria induce IL-6 and IL-10 production by dendritic cells, which contribute to upregulating the sIgA concentration at mucosal sites in humans.
the combined detection of IL-6 and tumour markers is critical to improve the specificity and sensitivity of lung cancer diagnosis. This in-depth study not only helped to elucidate the mechanism of how IL-6 promotes lung cancer but also provided new ideas and entry points to resolve the low specificity and sensitivity of lung cancer-related tumour markers.
IL-6 could induce autophagy by expressing NS5ATP9, while NS5ATP9 upregulated IL-6 levels in turn, which further induced autophagy.
In this context, we investigated in vivo study using the nitrosodiethyl amine (NDEA)-induced HCC model, which strengthened our previous findings by showing the blockade of the IL-6 mediated JAK2/STAT3 oncogenic signaling pathway.
This mechanism could exist in obese patients with prostate cancer. IL6-mediated inflammation could be a therapeutic target for prostate cancer
Monocyte-derived IL-6 is critical for augmenting liver damage and homeostatic disarrangement in mice.
The first three extracellular domains bind to IL-6-type cytokines.
IL-6 suppression is a critical feature of the protective mechanism against acute pneumovirus infection
IL-6 production in the tumor microenvironment may influence tumor growth.
In serum of human IL-1c transgenic mice, IL-6 and IL-17 levels significantly increased, and signal transducer and activator of transcription 3 (Stat3) was activated in joints.
IL-6 expression throughout life is involved in microglia priming and increased amounts of IL-6 is involved in exaggerated sickness behaviors in the aged.
the role of interleukin 6 (IL-6) associated with acute physical exercise in the control of the hypothalamic S1PR1-signal transducer and activator of transcription 3 (STAT3) axis, was examined.
Study showed that Malassezia furfur (commensal microorganisms colonized on human skin) produced extracellular vesicles, which could be then internalized into immortalized human keratinocyte HaCaT cell line, as well as mice epidermal keratinocytes. IL-6 expression was significantly enhanced in response to extracellular vesicular stimulation both in vitro and in vivo, in which process the activation of NF-kappaB was invo...
results indicate that IL-6 plays a pathogenic role in the HDM-induced asthma model and that lung macrophages and dendritic cells are the predominant sources of pathogenic IL-6 but contribute differently to the disease.
these findings suggest that IL6 is a rational immunosuppressive target for overcoming the narrow therapeutic window of anti-PD-1/PD-L1 therapy.Significance: These findings advance our understanding of IL6-PD1/PD-L1 cross-talk in the tumor microenvironment and provide clues for targeted interventional therapy that may prove more effective against cancer
the effects of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL6) gene knockout in preserving the bone loss induced by ovariectomy, was examined.
results suggest that IL-6 contributes, at the very least, to initiation of the neuronal regeneration program in remote dorsal root ganglia neurons after unilateral sciatic nerve injury
IL-6 signaling exacerbates acute intestinal injury and late intestinal injury after focal irradiation
Interleukin-6 accelerated in situ skeletal muscle fatigue in the WT.
blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain.
IL-6 signaling is both necessary and sufficient for adult neural stem cell self-renewal.
Delayed diabetic skin wound healing is associated with increased induction and expression of IL-6 and its receptor, but its function in epidermal keratinocytes may be impaired.
These results demonstrate that IL-6 is essentially involved in protective immune responses against early filarial infection within the skin that impair migration of infective Litomosoides sigmodontis.
IL-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis.
Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkeys.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt signaling pathway transactivator beta-catenin, induced expression of inhibitors of the Wnt pathway, and increased expression of GDF-5.
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR activation and that this effect can be modulated by A2AAR
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.
this study shows of IL-6 to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (signal transducer/activator of transcription 3) signaling pathway (including up-regulation of STAT3 expression/phosphorylation).
LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1, and apoptotic Bak and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
a parameter of early mRNA expression during intestinal ischemia reperfusion injury
These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
possible that IL-6 is produced in the granulosa cells of healthy follicles, that it increases the cFLIP(L) level, and cFLIP(L) then prevents apoptotic cell death
There is a direct link between IL-6 and ACTH release a sex difference in this relationship in stress
The data indicate that the development of clinical symptoms of coliform mastitis in the sow is associated with a locally increased proinflammatory cytokine production in response to intramammary Escherichia coli infection.
Eight polymorphisms in the IL6 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha and IL-6/sIL-6R in causing proteoglycan degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12), are potent inducers of IL-1beta and IL-6 gene expression and were equal to, or more potent than, crude LPS.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)