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anti-Human Interleukin 6 Antibodies:
anti-Mouse (Murine) Interleukin 6 Antibodies:
anti-Rat (Rattus) Interleukin 6 Antibodies:
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Human Monoclonal Interleukin 6 Primary Antibody for FACS - ABIN1383944
Lu, Brochier, Wijdenes, Brailly, Bataille, Klein: High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. in European journal of immunology 1992
Show all 60 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042620
Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. in Journal of cellular biochemistry 2011
Show all 29 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for ELISA, WB - ABIN3043248
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 27 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3043090
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
Show all 27 Pubmed References
Rat (Rattus) Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042526
Shi, Song, Zhang, Li, Li: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. in Experimental and therapeutic medicine 2013
Show all 27 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for WB - ABIN3042806
Chen, Zhao, Wu, Zou, Luo, Li, Xie, Liang: The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice. in International journal of clinical and experimental pathology 2015
Show all 21 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody for ICC, IF - ABIN269335
Bottino, Balamurugan, Tse, Thirunavukkarasu, Ge, Profozich, Milton, Ziegenfuss, Trucco, Piganelli: Response of human islets to isolation stress and the effect of antioxidant treatment. in Diabetes 2004
Show all 22 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for ELISA, WB - ABIN5693120
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. in Journal of experimental & clinical cancer research : CR 2010
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Human Monoclonal Interleukin 6 Primary Antibody for CyTOF, FACS - ABIN4900155
Maneechotesuwan, Wamanuttajinda, Kasetsinsombat, Huabprasert, Yaikwawong, Barnes, Wongkajornsilp: Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. in The Journal of allergy and clinical immunology 2009
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Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody for IF (p), IHC (p) - ABIN728083
Sun, Zeng, Cao, Song, Zhang, Liu: Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue. in BioMed research international 2015
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The increased levels of serum procollagen 1 C-terminal peptide in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis.
High IL6 expression is associated with M2-like polarization and triple-negative breast cancer cell invasion.
These findings constitute further evidence that inflammation plays a role in breast cancer. Interventions to lower CRP, TNF-alpha, and interleukin-6 and increase adiponectin levels may contribute to preventing Breast cancer .
TNF-[alpha] rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for acute respiratory distress syndrome (ARDS); G allele at MyD88 rs7744 locus was a protective factor. Homozygotes for TNF-[alpha] rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci had higher expression levels, of which homozygotes for TNF-[alpha] rs1800629 and IL-6 rs1800796 loci had lower 60-day survival rates.
IL6 polymorphisms modify the effects of smoking on the risk of adult asthma.
Increased serum concentrations of interleukin IL-6, IL-8, and TNF-alpha may suggest that these cytokines induce inflammatory changes in the ocular surface.
Studied the association of interleukin 6 (IL-6) C-174G single nucleotide polymorphism (SNP) with type 2 diabetes mellitus (T2DM) in a Pakistani population; found the IL-6 C-174G SNP to be a risk factor for T2DM.
Study revealed that IL-6, which was expressed in the lung induced cancer stem cells (CSCs), facilitates the formation of lung cancer organoids via the conversion of mesenchymal stem cells into alpha-SMA-positive cells. Furthermore, IL-6 mRNA-positive cancer cells were found in clinical lung cancer samples.
A model comprising maternal serum levels of IL-6 plus maternal characteristics proves to be a good non-invasive predictor of histological chorioamnionitis .
Data show that the pro-inflammatory proteins interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were significantly associated with major depressive disorder (MDD), while C-reactive protein (CRP) was not.
IL-6 and IL-8 were significantly elevated in preterm infants with definitive surgical necrotizing enterocolitis but not those with feeding intolerance.
High serum IL6 level is associated with pancreatic cancer.
idiopathic multicentric Castleman disease symptoms and disease progression are believed to be driven by a cytokine storm, often including interleukin-6 (IL-6). However, approximately two-thirds of patients do not respond to anti-IL-6 therapy
GPER can suppress the migration and invasion of OS cells via inhibition of IL-6 and IL-8
The levels of inflammation cytokine, Il-6 were increased in elderly sarcopenia subjects.
A significant relationship was observed between calcium level and IL-6 (rs1800796) genotype in osteoporotic patients. Also, IL-6 (rs1800796) influences serum calcium levels in osteoporotic patients but no association was found with bone mineral density.
Authors report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 (IL-6) signaling can manipulate vasculogenic mimicry (VM) formation of MDA-MB-231 breast cancer cells. We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells.
Patients with CD [ Crohn's disease ] are at a higher risk of skeletal pathology than patients with UC [ulcerative colitis ]. IL-6 can modulate bone mineral density in the femoral neck especially in the course of CD.
Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1.
The present results indicate that activation of the IL-6/STAT3 pathway contributes to the pathogenesis of thromboangiitis obliterans (TAO) by regulating cellular adhesion molecules and cytoskeleton of vascular endothelial cells.
These results demonstrate that IL-6 is essentially involved in protective immune responses against early filarial infection within the skin that impair migration of infective Litomosoides sigmodontis.
IL-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis.
Bone marrow PDGFRalpha+Sca-1+-enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6
Our results indicate that IL-6 plays a key role in T cell expansion during inflammation and implicates a role for the transient induction of low-level RORgammat.
These data demonstrate that RORgammat expressed by tumor-infiltrating Tregs sustains tumor growth by leaving IL6 expression in dendritic cells unchecked.
dopamine D2 receptor upregulates leptin and IL-6 in adipocytes
Systemic IL-6 overexpression in precachectic tumor-bearing Apc(Min/+) mice accelerated cachexia development.
ADAM17 is needed for EGF-R-mediated induction of IL-6 synthesis, which via IL-6 trans-signaling induces beta-catenin-dependent tumorigenesis.
Results suggest that adenine nucleotide translocator 1 (ANT1) modulates interleukin-6 (IL-6) expression through JNK signal pathway in macrophages.
In whole skin of skin-specific deficiency of SCD1 (SKO) mice, IL-6 mRNA levels are increased, and protein expression is evident in hair follicle cells and in keratinocytes.
Physiological temperature (37 degrees C) and O2 supply were essential for the induction of Interleukin 6 (IL-6) release from the incubated muscle, suggesting it is a controlled secretion rather than a spontaneous leak.
Mouse model of acute kidney injury (AKI) has an increase in bone FGF23 mRNA expression and increase in serum FGF23 and IL-6. IL-6 knock-out mice fed an adenine diet to induce chronic kidney disease (CKD) failed to increase bone FGF23 mRNA and had a muted increase in serum FGF23 levels. IL-6 increases FGF23 transcription and contributes to the high levels of serum FGF23 in both acute and chronic kidney disease.
miR-151-3p inhibited lipopolysaccharide-induced IL-6 production by targeting Stat3.
regulation of IL-6 levels during psoriasis by let-7b
NEU1/3 activity mediates IL-6 production in lupus-prone mesangial cells possibly through an IgG-receptor complex signaling pathway.
our findings provide evidence that increased spinal cord CALP2 and microglia cell activation may have early causative roles in IL-6 over-expression following motor nerve injury
Denervation-activated fibro-adipogenic progenitors exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis.
chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle.
this study shows that donor IL-6 deficiency evidently reduces memory T cell responses in sensitized transplant recipients
IL-6 trans-signalling inhibition prevented the increase in osteoclasts, and trabecular bone loss, associated with ovariectomy.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt signaling pathway transactivator beta-catenin, induced expression of inhibitors of the Wnt pathway, and increased expression of GDF-5.
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR activation and that this effect can be modulated by A2AAR
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.
this study shows of IL-6 to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (signal transducer/activator of transcription 3) signaling pathway (including up-regulation of STAT3 expression/phosphorylation).
LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1, and apoptotic Bak and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
a parameter of early mRNA expression during intestinal ischemia reperfusion injury
These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
possible that IL-6 is produced in the granulosa cells of healthy follicles, that it increases the cFLIP(L) level, and cFLIP(L) then prevents apoptotic cell death
There is a direct link between IL-6 and ACTH release a sex difference in this relationship in stress
The data indicate that the development of clinical symptoms of coliform mastitis in the sow is associated with a locally increased proinflammatory cytokine production in response to intramammary Escherichia coli infection.
Eight polymorphisms in the IL6 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha and IL-6/sIL-6R in causing proteoglycan degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12), are potent inducers of IL-1beta and IL-6 gene expression and were equal to, or more potent than, crude LPS.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)