Browse our anti-omega-3 Fatty Acid Receptor 1 (O3FAR1) Antibodies

Human omega-3 Fatty Acid Receptor 1 (O3FAR1) interaction partners

1. Data suggest that cytokines TNFalpha (show TNF Antibodies) and interleukin-1b markedly reduce GPR120/FFAR4 expression in adipocytes; in contrast, these cytokines induce expression of GPR84 (show GPR84 Antibodies) and GPR41/FFAR3 (show FFAR3 Antibodies) in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR (show ALDH18A1 Antibodies) = G-protein coupled receptor (show ADRA1A Antibodies); FFAR = free fatty acid receptor)

2. Fatty acids are capable of directly acting on visceral adipocytes to modulate differently TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-10 (show IL10 Antibodies) and adiponectin expression, with a different and greater effect in morbidly obese subjects. These effects are largely annulled when GPR120 expression was silenced, which suggests that they could be mediated by GPR120.

3. The results of this study suggest that n-3 PUFA protect hepatic steatosis by activating FFA4 in hepatocytes, and its signaling cascade sequentially involves FFA4, Gq/11 proteins, CaMKK (show CAMKK2 Antibodies), AMPK (show PRKAA1 Antibodies), and SREBP-1c (show SREBF1 Antibodies) suppression.

4. Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 (show AKT2 Antibodies) activation requires EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies) activity, whereas migration and invasion are dependent on FFAR4, EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) activity.

5. Eicosapentaenoic acid prevents TNF-alpha (show TNF Antibodies)-induced decrease of alpha-methylglucose uptake and AMPK (show PRKAA1 Antibodies) phosphorylation in Caco-2 cells via GPR120 and AMPK (show PRKAA1 Antibodies) activation.

6. P.R270H of FFAR4 impairs Gq and Gi signalling of FFAR4 in vitro.

7. G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin (show INS Antibodies) resistance. This review summarizes recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. [review]

8. p.R270H variant of GPR120 modulates the risk of type 2 diabetes in interaction with dietary fat intake.

9. These results indicated that GPR120 enhanced and GPR40 (show FFAR1 Antibodies) inhibited the cell motile activity of highly migratory osteosarcoma cells.

10. LPA1 (show LPAR1 Antibodies) plays a critical role in EGF (show EGF Antibodies) responses and that FFA4 agonists inhibit proliferation by suppressing positive cross-talk between LPA1 (show LPAR1 Antibodies) and the EGF receptor (show EGFR Antibodies)

Mouse (Murine) omega-3 Fatty Acid Receptor 1 (O3FAR1) interaction partners

1. Ovarian hormones may directly regulate GPR120 expression in the reproductive cycle at the pituitary level.

2. Data suggest that omega-3 fatty acids, common dietary lipids, participate in immunomodulation; here, EPA (eicosapentaenoic acid) activates macrophage RAW264.7 cells through GPR120-mediated Raf (show RAF1 Antibodies)-ERK1/2-IKKbeta (show IKBKB Antibodies)-NFkappaB p65 (show NFkBP65 Antibodies) signaling pathways.

3. GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 (show FFAR1 Antibodies) in antidiabetic efficacy

4. Docosahexaenoic acid activates GPR120 to prevent experimental colitis in IL-10 (show IL10 Antibodies) deficient mice.

5. GPR120 (and GPR40 (show FFAR1 Antibodies)) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity.

6. Acute reductions in food intake and food reward suggest that GPR120 could mediate the effects of central omega-3 polyunsaturated fatty acids to inhibit appetite.

7. These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (show ROS1 Antibodies) in macrophages.

8. Results provide evidence that GPR120 promotes adipogenesis by increasing PPARgamma expression via [Ca(2+)]i and ERK1/2 signal pathway in 3T3-L1 adipocytes.

9. GPR120-induced incretin glucse-dependent insulinotropic polypeptide secretion is indirectly mediated by cholecystokinin (show CCK Antibodies).

10. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor (show LDLR Antibodies) KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo

Pig (Porcine) omega-3 Fatty Acid Receptor 1 (O3FAR1) interaction partners

1. GPR120 is highly expressed in porcine mature adipose tissue and is positively associated with adipose tissue development. 5 CpG islands across GPR120 gene exhibit different methylation states. DNA methylation (show HELLS Antibodies) of GPR120 5'-untranslated and first exon regions can negatively regulate its expression levels.

2. C/EBP-beta (show CEBPB Antibodies) plays a vital role in regulating GPR120 transcription.