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Human Polyclonal O3FAR1 Primary Antibody for ICC, IF - ABIN314627
Liu, Chen, Sokolowska, Eberlein, Alsaaty, Martinez-Anton, Logun, Qi, Shelhamer: The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A₂ via GPR120 receptor to produce prostaglandin E₂ and plays an anti-inflammatory role in macrophages. in Immunology 2014
Show all 13 Pubmed References
Human Polyclonal O3FAR1 Primary Antibody for IF (p), IHC (p) - ABIN1387736
Meng, Yuan, Zhang, Zhang, Fu, Zhu, Shu, Wang, Gao, Xi, Sun, Zhang, Jiang, Wang: Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. in Biochemical and biophysical research communications 2017
Human Polyclonal O3FAR1 Primary Antibody for ELISA, IHC (p) - ABIN451730
Gotoh, Hong, Iga, Hishikawa, Suzuki, Song, Choi, Adachi, Hirasawa, Tsujimoto, Sasaki, Roh: The regulation of adipogenesis through GPR120. in Biochemical and biophysical research communications 2007
Human Polyclonal O3FAR1 Primary Antibody for IHC (p) - ABIN270758
Milton, Khaire, Ingram, ODonnell, La Thangue: 14-3-3 proteins integrate E2F activity with the DNA damage response. in The EMBO journal 2006
Human Polyclonal O3FAR1 Primary Antibody for IHC (p) - ABIN4311410
Li, Kokrashvili, Mosinger, Margolskee: Gustducin couples fatty acid receptors to GLP-1 release in colon. in American journal of physiology. Endocrinology and metabolism 2013
Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 (show AKT2 Antibodies) activation requires EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies) activity, whereas migration and invasion are dependent on FFAR4, EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) activity.
Eicosapentaenoic acid prevents TNF-alpha (show TNF Antibodies)-induced decrease of alpha-methylglucose uptake and AMPK (show PRKAA1 Antibodies) phosphorylation in Caco-2 cells via GPR120 and AMPK (show PRKAA1 Antibodies) activation.
P.R270H of FFAR4 impairs Gq and Gi signalling of FFAR4 in vitro.
G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin (show INS Antibodies) resistance. This review summarizes recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. [review]
p.R270H variant of GPR120 modulates the risk of type 2 diabetes in interaction with dietary fat intake.
These results indicated that GPR120 enhanced and GPR40 (show FFAR1 Antibodies) inhibited the cell motile activity of highly migratory osteosarcoma cells.
LPA1 (show LPAR1 Antibodies) plays a critical role in EGF (show EGF Antibodies) responses and that FFA4 agonists inhibit proliferation by suppressing positive cross-talk between LPA1 (show LPAR1 Antibodies) and the EGF receptor (show EGFR Antibodies)
Ligands for FFAR4 comprise the family of long chain polyunsaturated fatty acids, suggesting that many of the long-known beneficial effects of these fats (show C10ORF90 Antibodies) may be receptor mediated. (Review)
It promotes the secretion of glucagon-like peptide-1 (GLP-1 (show GCG Antibodies)) in the intestine, and also acts as a lipid sensor in adipose tissue to sense dietary fat and control energy balance.(review)
demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders
Docosahexaenoic acid activates GPR120 to prevent experimental colitis in IL-10 (show IL10 Antibodies) deficient mice.
GPR120 (and GPR40 (show FFAR1 Antibodies)) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity.
Acute reductions in food intake and food reward suggest that GPR120 could mediate the effects of central omega-3 polyunsaturated fatty acids to inhibit appetite.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (show ROS1 Antibodies) in macrophages.
Results provide evidence that GPR120 promotes adipogenesis by increasing PPARgamma expression via [Ca(2+)]i and ERK1/2 signal pathway in 3T3-L1 adipocytes.
GPR120-induced incretin glucse-dependent insulinotropic polypeptide secretion is indirectly mediated by cholecystokinin (show CCK Antibodies).
Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor (show LDLR Antibodies) KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo
Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 (show CCL2 Antibodies) proliferation, and was associated with inhibition of PI3K/Akt (show AKT1 Antibodies) signaling pathway through activation of GPR120.
GPR120 silencing in adipocytes inhibited the expression of PPARgamma (show PPARG Antibodies) and miR (show MLXIP Antibodies)-143, whereas GPR120 overexpression led to increased expressions of PPARgamma (show PPARG Antibodies) and miR (show MLXIP Antibodies)-143.
GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma (show PPARG Antibodies).
GPR120 is highly expressed in porcine mature adipose tissue and is positively associated with adipose tissue development. 5 CpG islands across GPR120 gene exhibit different methylation states. DNA methylation (show HELLS Antibodies) of GPR120 5'-untranslated and first exon regions can negatively regulate its expression levels.
C/EBP-beta (show CEBPB Antibodies) plays a vital role in regulating GPR120 transcription.
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 120
, G-protein coupled receptor 129
, G-protein coupled receptor GT01
, G-protein coupled receptor PGR4
, omega-3 fatty acid receptor 1
, G protein-coupled receptor 120
, G-protein-coupled receptor GT01