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Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 (show CACNA1A Proteins) variant containing the region encoded by exons 44 and 47.
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 (show CACNA1D Proteins) gating kinetics in immature cochlear inner hair cells.
Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia.
tick-borne encephalitis virus -NS5 (show RAF1 Proteins) has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 (show RAF1 Proteins) binds primarily to the tight junction protein (show OCLN Proteins) zonula occludens-1 (ZO-1 (show TJP1 Proteins))
The function of RIM1/2 at rod ribbons is to enhance Cav1.4 (show CACNA1F Proteins) channel activity, possibly through direct or indirect modulation of the channel.
RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 (show CACNA1D Proteins) Ca(2 (show CA2 Proteins)+) channels at inner hair cell presynaptic active zones and are required for normal hearing.
Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking
Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2 (show CA2 Proteins))+ channel density and vesicle docking at the active zone.
Rim2alpha determines docking and priming states in insulin granule exocytosis depending on its interacting partner, Rab3A or Munc13-1, respectively.
Alternative splicing in the Rab (show HRB Proteins)-binding domain of Rim2 (show AP3B1 Proteins) regulates Rab3A (show RAB3A Proteins) binding activity.
These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2 (show CA2 Proteins)+)-triggering of exocytosis.
Cyclic AMP (show TMPRSS5 Proteins) rescue of priming defects caused by Munc13-1 deficiency signaling pathways requires downstream Munc13-1-Rim2 (show AP3B1 Proteins) interaction.
synaptic protein important for normal neurotransmitter release\; binds Rab3a
regulating synaptic membrane exocytosis 2
, RAB3 interacting protein 3
, RIM 2
, non-small cell lung cancer RimL3a protein
, non-small cell lung cancer RimL3c protein
, nuclear protein
, rab-3-interacting molecule 2
, rab-3-interacting protein 3
, rab3-interacting molecule 2
, regulating synaptic membrane exocytosis protein 2
, Rab3 interacting protein 1
, Rab3 interacting protein 2
, rab-3-interacting protein 2
, rab3-interacting protein 2
, synaptic exocytosis regulator 2
, synaptotagmin 3, related sequence