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Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells.
Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia.
tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1)
RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel.
RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2+) channels at inner hair cell presynaptic active zones and are required for normal hearing.
Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking
Rim2alpha is involved in Zona Pellucida dependent signaling.
Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2)+ channel density and vesicle docking at the active zone.
Rim2alpha determines docking and priming states in insulin granule exocytosis depending on its interacting partner, Rab3A or Munc13-1, respectively.
Alternative splicing in the Rab-binding domain of Rim2 regulates Rab3A binding activity.
These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis.
Cyclic AMP rescue of priming defects caused by Munc13-1 deficiency signaling pathways requires downstream Munc13-1-Rim2 interaction.
synaptic protein important for normal neurotransmitter release\; binds Rab3a
RAB3 interacting protein 3
, RIM 2
, non-small cell lung cancer RimL3a protein
, non-small cell lung cancer RimL3c protein
, nuclear protein
, rab-3-interacting molecule 2
, rab-3-interacting protein 3
, rab3-interacting molecule 2
, regulating synaptic membrane exocytosis protein 2
, Rab3 interacting protein 1
, Rab3 interacting protein 2
, rab-3-interacting protein 2
, rab3-interacting protein 2
, synaptic exocytosis regulator 2
, synaptotagmin 3, related sequence
, regulating synaptic membrane exocytosis 2
, pinin, desmosome associated protein S homeolog