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data indicate that OCT1 (show POU2F1 Proteins) may contribute to uptake metformin and regulate pancreatic stellate cells (PSCs) activity. OCT1 (show POU2F1 Proteins) is a target of metformin in regulating PSCs activity.
Treatment with peroxisome proliferator activated receptor gamma (PPARgamma (show PPARG Proteins)) ligands significantly alters organic cation transporter-1 (OCT-1) activity in BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins)+ chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)) cell lines.
inhibitory potency for morphine uptake was affected by the OCT1 (show POU2F1 Proteins)*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism
Results indicated that OCT1 rs628031 and ABCG2 rs2231142 were associated with plasma lamotrigine concentrations in Han Chinese patients with epilepsy.
The pregnane X receptor (show NR1I2 Proteins) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC Proteins) coactivator.
Variants of SLC22A1 gene are associated with serum acylcarnitines and metabolic diseases.
Results indicate that the interaction between OCT1 (show POU2F1 Proteins) and SERT (show SLC6A4 Proteins) genes might play an important role in metformin gastrointestinal intolerance.
summarize current understanding of human OCT1 (show POU2F1 Proteins) transporter hepatic gene regulation and propose potential post-transcriptional regulation by predicted miRNAs.
The response to 6 months of metformin treatment (HbA1c , homeostasis model assessment for insulin (show INS Proteins) resistance, fasting insulin (show INS Proteins), and glucose changes) did not differ between SLC22A1 wild-type subjects and carriers of presumably low-activity SLC22A1 alleles
we assessed the role of miR (show MLXIP Proteins)-21 in mediating renal cell carcinoma (show MOK Proteins) chemoresistance and further showed that miR (show MLXIP Proteins)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2 (show SLC22A2 Proteins), and SLC31A1/CTR1 (show SLC31A1 Proteins) platinum influx transporter expression
Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (show POU2F1 Proteins) and OCT-2 (show SLC22A2 Proteins).
Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 (show SLC22A2 Proteins) and Slc22a3 (show OCT3 Proteins) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
The influence of organic cation transporters 1, 2, and 3 (OCT1 (show POU2F1 Proteins), OCT2 (show SLC22A2 Proteins), and OCT3 (show POU5F1 Proteins)) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.
Oct1 (show POU2F1 Proteins) forms repeating, cyclosporin-sensitive regulatory modules within the CD21 (show CR2 Proteins) intronic control region.
a comparison of the transport properties of Oct2 (show SLC22A2 Proteins) and Oct1 (show POU2F1 Proteins)
oct1 (show POU2F1 Proteins) has a role in controlling fgl2 (show FGL2 Proteins) expression in endothelial cells
This study shows that Oct1 (show POU2F1 Proteins) and Oct2 (show SLC22A2 Proteins) together are essential for renal secretion of (small) organic cations.
nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene
The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1.
a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
solute carrier family 22 member 1
, solute carrier family 22 (organic cation transporter), member 1
, solute carrier family 22 member 1-like
, organic cation transporter 1
, solute carrier family 22, member 1
, solute carrier family 22 (organic cation transporter), member 2