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identified two different TBX3 alleles causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 TBX3 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication
TBX3 is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites.
High TBX3 expression is associated with invasive breast cancer.
genetic variation of Tbx3 is associated with left ventricular mass in a healthy Japanese population [meta-analysis]
Study demonstrates that miR (show MLXIP Proteins)-206 directly targets Tbx3, that miR (show MLXIP Proteins)-206 and Tbx3 mRNA are inversely correlated in human breast cancer and that Tbx3 repression is necessary to elicit a significant functional effect of miR (show MLXIP Proteins)-206 in breast cancer cells.
The c.1423C>T (p.Q475*) nonsense mutation in exon 6 of the TBX3 gene associated with ulnar-mammary syndrome.
Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples
These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 and TBX5 (show TBX5 Proteins), and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1 (show LMBR1 Proteins)
this new molecular-grade based on the combination of TBX2 (show TBX2 Proteins) and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Paracrine WNT (show WNT2 Proteins) signaling is stimulated by estrogen and progesterone, while autocrine WNT (show WNT2 Proteins) signaling is induced by the embryonic T-box transcription factor TBX3
Overexpression of Tbx3 is associated with pancreatic carcinoma.
Tbx3 is required for abdominal skin expansion in pregnant mice.
Tbx2 (show TBX2 Proteins) and Tbx3 function downstream of Shh (show SHH Proteins) to maintain pro-proliferative mesenchymal Wnt (show WNT2 Proteins) signaling.
Tbx3 functions upstream of Hes1 (show HES1 Proteins) to regulate proliferation and differentiation of basal and suprabasal cells during epidermal development.
T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu (show SUFUH Proteins) complex that regulates Gli3 (show GLI3 Proteins) stability and processing.
Low TBX3 levels are associated with reduced pluripotency for embryonic stem cells, resembling the more mature epiblast.
miR (show MLXIP Proteins)-93 controls Tbx3 expression, thereby limiting self-renewal in early adipocyte precursors.
In-depth transcriptome analysis of this mESC state reveals Dppa3 (show DPPA3 Proteins) as a direct downstream target of Tbx3.We show that Tbx3, a downstream target of Wnt (show WNT2 Proteins) signaling, fine tunes these divergent roles of Wnt (show WNT2 Proteins) signaling in mESCs
Hoxc8 (show HOXC8 Proteins) initiates an ectopic mammary program by regulating Fgf10 (show FGF10 Proteins) and Tbx3 expression and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
Tbx3 can activate Zscan4 (show ZSCAN4 Proteins)(+)/2C state by negative regulation of DNA methylation (show HELLS Proteins) at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.
Results suggested that Tbx3 and Nr5alpha2 may have vital roles in pluripotent stem cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms\; however, the full length nature of one variant has not been determined.
, transcription factor Tbx3
, T-box 3 protein
, T-box 3 (ulnar mammary syndrome)
, T-box transcription factor TBX3-like
, t-box transcription factor TBX3-like
, T-box protein 3
, T-box transcription factor TBX3
, bladder cancer related protein XHL
, T-Box protein 3