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Increased CDIPT expression was found to be an early event in oral cancer and a target for smokeless tobacco.
AAT Deficiency affects at least 120.5 million carriers and deficient subjects worldwide for the two most prevalent deficiency alleles PIZ.
Analyses of a zebrafish insertional mutant suggest an essential role of Cdipt in phosphatidylinositol synthesis and disruption of Cdipt causes hepatocellular ER stress and steatosis.
Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.
, PtdIns synthase
, phosphatidylinositol synthase
, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
, ptdIns synthase
, CDP-diacylglycerol-inositol 3-phosphatidyltransferase
, CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
, CDP-diacylglycerol--inositol 3-phosphatidyltransferase L homeolog