Browse our PI4K2A Proteins (PI4K2A)

Rhesus Monkey Phosphatidylinositol 4-Kinase Type 2 alpha (PI4K2A) interaction partners

1. phosphatidylinositol 4-kinase (show PI4KB Proteins) IIalpha knockdown inhibited vesicle-associated membrane protein 3 (show VAMP3 Proteins) trafficking to perinuclear membranes and impaired the rate of VAMP3 (show VAMP3 Proteins)-mediated recycling of the transferrin receptor

Human Phosphatidylinositol 4-Kinase Type 2 alpha (PI4K2A) interaction partners

1. Mining oncogenomic databases revealed that loss of the PI4K2B (show PI4K2B Proteins) allele and underexpression of PI4KIIbeta (show PI4K2B Proteins) mRNA are associated with human cancers. This finding supports the cell data and suggests that PI4KIIbeta (show PI4K2B Proteins) may be a clinically significant suppressor of invasion.

2. RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF (show VWF Proteins), as exemplified by increased exposure of antibody-binding sites.

3. Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B (show PI4K2B Proteins) containing a nucleoside analogue.

4. PI4KIIalpha is a specific downstream effector of GABARAP (show GABARAP Proteins) and it generates PI4P, which has a key role in the final stage of autophagy.

5. phosphatidylinositol 4-kinase (show PI4KA Proteins) IIalpha knockdown inhibited vesicle-associated membrane protein 3 (show VAMP3 Proteins) trafficking to perinuclear membranes and impaired the rate of VAMP3 (show VAMP3 Proteins)-mediated recycling of the transferrin receptor

6. PI4K2A is a novel regulator of vesicular trafficking and neurotransmission in the brain.

7. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton.

8. Knockdown of PI4KIIalpha inhibits EGF (show EGF Proteins)-stimulated Akt (show AKT1 Proteins) phosphorylation.

9. Results suggest that the phosphatidylinositol 4-kinase 2-alpha gene may not be a cause of autosomal recessive hereditary spastic paraplegia in humans.

10. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha (show HIF1A Proteins) regulation.

Mouse (Murine) Phosphatidylinositol 4-Kinase Type 2 alpha (PI4K2A) interaction partners

1. Itch directly associates with and ubiquitinates PI4KIIalpha, and both proteins colocalize on endosomes containing Wnt (show WNT2 Proteins)-activated frizzled 4 (Fz4 (show FZD4 Proteins)) receptor

2. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha (show HIF1A Proteins) regulation.

3. PI4KIIalpha is present on adaptor protein (AP) -3 organelles where it regulates AP-3 function

4. The unique N terminus of PI4K type IIalpha is required for the targeting of the enzyme to cellugyrin (show SYNGR2 Proteins)-positive vesicles.

5. AP-3 (show AP3B1 Proteins) and BLOC-1 (show PLDN Proteins) act, either in concert or sequentially, to specify sorting of PI4KIIalpha along the endocytic route.