Browse our PIGV Proteins (PIGV)

Full name:: Phosphatidylinositol Glycan Anchor Biosynthesis, Class V Proteins (PIGV)

On www.antibodies-online.com are 3 Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV) Proteins from 2 different suppliers available. Additionally we are shipping PIGV Antibodies (25) and many more products for this protein. A total of 31 PIGV products are currently listed.

Synonyms:: B330013B03, D430024F16Rik, GPI-MT-II, HPMRS1, PIG-V, RGD1309526

list all proteins	Gene Name	GeneID	UniProt
	PIGV	55650	Q9NUD9
	PIGV	230801	Q7TPN3
Rat PIGV	PIGV	366478	Q5KR61
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PIGV Proteins (PIGV) by Origin

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Relevant Pathways for PIGV Proteins

Inositol Metabolic Process

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Human Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV) interaction partners

Data indicate that mannosyltransferases PIGV mutations are the major cause of hyperphosphatasia-mental retardation syndrome (HPMRS) which displays a broad clinical variability regarding associated malformations and growth patterns.
PIGV is the rate-limiting enzyme in GPI (show GNPDA1 Proteins) biosynthesis under limited dolicholphosphate mannose availability.
Hyperphosphatasia resulted from secretion of ALP (show ALP Proteins), a GPI (show GNPDA1 Proteins)-anchored protein normally expressed on the cell surface, into serum due to PIGV deficiency.
novel compound heterozygous mutations in the PIGV gene c.467G>A and c.1022C>A and a homozygous mutation c.1022C>A in hyperphosphatasia-mental retardation syndrome
PIGV mutations are associated with hyperphosphatasia mental retardation syndrome.
PIG-V is the second mannosyltransferase in GPI anchor biosynthesis (show PIGA Proteins).

PIGV Protein Profile

Protein Summary

This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia mental retardation syndrome. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with PIGV

phosphatidylinositol glycan anchor biosynthesis class V (PIGV)
zinc finger DHHC-type containing 18 (ZDHHC18)
phosphatidylinositol glycan anchor biosynthesis, class V (Pigv)

B330013B03 protein
D430024F16Rik protein
GPI-MT-II protein
HPMRS1 protein
PIG-V protein
RGD1309526 protein

Protein level used designations for PIGV

GPI mannosyltransferase 2 , GPI mannosyltransferase II , Ybr004c homolog , dol-P-Man dependent GPI mannosyltransferase , GPI-MT-II , PIG-V , phosphatidylinositol glycan class V , phosphatidylinositol glycan, class V , phosphatidylinositol-glycan biosynthesis class V protein

GENE ID	SPECIES
55650	Homo sapiens
478172	Canis lupus familiaris
519213	Bos taurus
230801	Mus musculus
366478	Rattus norvegicus

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