Browse our PLA2G10 Proteins (PLA2G10)

Mouse (Murine) Phospholipase A2, Group X (PLA2G10) interaction partners

1. secretory PLA2s (show PLA2G2A Proteins) have important functions as genetic modifiers of inflammation and colon cancer.

2. PLA2G10 releases omega-3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility.

3. Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (show PLA2G6 Proteins)) and Group X Secreted Phospholipase A2 (show YWHAZ Proteins) (sPLA2 (show PLA2G2A Proteins)).

4. GX sPLA2 negatively regulated pancreatic insulin (show INS Proteins) secretion by augmenting COX-2-dependent PGE2 production.

5. Mouse PLA2GX has a unique property of improving fertilization outcome among other secreted phospholipase A2 (show YWHAZ Proteins) isoforms.

6. Data indicate that experimental allergic bronchitis (EAB) in was associated with increased expression of sPLA2 (show PLA2G2A Proteins), specifically sPLA2gX, in the lungs.

7. Authors propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival.

8. Pla2G10 limits the development of atherosclerosis in LDL receptor-nul (show HAND1 Proteins)l mice.

9. the use of a highly potent indole-based inhibitor of hGX-sPLA(2 (show PLA2G2A Proteins)), RO061606 (which is ineffective against mGX-sPLA(2 (show PLA2G2A Proteins))), to assess the potential utility of GX-sPLA(2) blockade as a therapeutic intervention in asthma.

10. sPLA(2 (show PLA2G2A Proteins))-X in neutrophils plays a pathogenic role in abdominal aortic aneurysms in a mouse model.

Human Phospholipase A2, Group X (PLA2G10) interaction partners

1. This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.

2. Data show that phospholipase A2 group IIA, V and X have different target/function related activity.

3. PLA2G10 releases omega-3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility.

4. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils

5. PLA2G10 variants are not significantly associated with plasma sPLA2 (show PLA2G2A Proteins) activity or with CHD (show CHDH Proteins) risk.

6. Studies indicate that the expression of secreted phospholipases A2 (sPLA2s), most notably the group IIA, III and X enzymes, is dysregulated in various malignant tissues.

7. hGX sPLA2 (show PLA2G2A Proteins) is a novel modulator of lipid metabolism that promotes breast cancer cell growth and survival by stimulating lipid droplet formation and fatty acid oxidation.

8. Data indicate that the expression of genes encoding hGIIA, hGIII and hGX sPLA2s (show PLA2G2D Proteins) (PLA2G2A (show PLA2G2A Proteins), PLA2G3 (show PLA2G3 Proteins) and PLA2G10, respectively) in breast tumour biopsies differs from that in normal tissues.

9. The enzyme activity of sPLA2 (show PLA2G2A Proteins) is not altered in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis during the course of the disease.

10. Secreted phospholipase A2 group X plays a key role in regulating eicosanoid formation and the development of inflammation and airway hyperresponsiveness in murine models.