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Mouse (Murine) PLAUR Protein expressed in Human Cells - ABIN2007425
Dear, Medcalf: The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule. in European journal of biochemistry / FEBS 1998
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Human PLAUR Protein expressed in HEK-293 Cells - ABIN2713801
Ge, Siegel, Jordan, Naumann: Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures. in Biophysical journal 2014
Plg-RKT is required for plasminogen (show PLG Proteins) binding and macrophage migration in vivo
The synergy of circulating factor suPAR and APOL1 (show APOL1 Proteins) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
Results identify soluble uPAR as a functional connection between the bone marrow and the kidney, and they implicate bone marrow immature myeloid cells as a key source of soluble uPAR that leads to glomerular dysfunction.
Plaur deficiency does not increase susceptibility to epileptogenesis after traumatic brain injury in an animal model.
Significance of the urokinase-type plasminogen activator (show PLAU Proteins) and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
Findings indicate a significant correlation of uPAR cleavage with breast cancer progression, but the precise biological consequence(s) of the cleavage or the cleavage products still remains to be elucidated.
interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin (show NPHS1 Proteins) that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.
In an in vivo murine angiogenesis model uPAR-deficient PTEN heterozygous animals increased the impaired angiogenic phenotype of uPAR knockout mice and were able to reverse the high invasive potential of PTEN heterozygotes.
uPAR contributes to macrophage driven atherosclerotic lesion formation.
we have firstly shown a fundamental mechanism of urokinase system(uPa (show PLAU Proteins) and uPAR)-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Sera and tissues from malignant mesothelioma (MM) patients showed significantly high plasminogen activator urokinase receptor (uPAR) levels, suggesting the pathogenic role of uPAR in the tumor biology of MM.
Levels of circulating cleaved soluble forms plasminogen activator urokinase receptor (DIIDIII-suPAR) in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) patients are higher as compared to controls and significantly decrease after the conditioning.
Serum soluble urokinase-type plasminogen activator receptor as a serum marker of inflammatory response that leads to tissue damage and surgical complication
Two interacting partners of urokinase-type plasminogen activator (uPA) receptor, the cysteine-rich angiogenic inducer 61 (Cyr61 (show CYR61 Proteins)) and the Y-box-binding protein 1 (YB-1 (show YBX1 Proteins)) were identified and their differential expression demonstrated in the triple-negative breast cancer (TNBC) cells as well as in tumors.
Study provides evidence that the stimulation of u-PA (show PLAU Proteins)/u-PAR system contributes to the activated phenotype and function of cancer-associated fibroblasts during multiple myeloma.
Binding of uPAR to VN triggers integrin-mediated signals, which result in ERK1-2 and RAC (show AKT1 Proteins) activation, accumulation of ROS (show ROS1 Proteins), and senescence.
Plasma levels of intact and cleaved urokinase plasminogen activator receptor do not hold important predictive or prognostic information in men with clinically localised prostate cancer.
This study provides novel data that elevated airway and blood uPAR is a feature of asthma and that blood uPAR is particularly related to severe, nonatopic asthma.
Moesin (show MSN Proteins) and merlin (show NF2 Proteins) regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis
uPAR and mTORC2 (show CRTC2 Proteins) are components of a single cell-signaling pathway.
Data show that urokinase-type plasminogen activator (uPA (show PLAU Proteins)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (show PLAU Proteins) receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1 (show SERPINE1 Proteins)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA (show PLAU Proteins)/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
These data indicated that E. coli LPS (show IRF6 Proteins) led to an increase in u-PA (show PLAU Proteins) activity and RNA expression of u-PA (show PLAU Proteins) and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
the interaction between uPAR and Man-6-P/IGF2R (show IGF2R Proteins) is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R (show IGF2R Proteins) by different mechanisms.
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
urokinase plasminogen activator surface receptor
, plasminogen activator, urokinase receptor
, urokinase plasminogen activator receptor
, urokinase-type plasminogen activator receptor
, monocyte activation antigen Mo3
, u-plasminogen activator receptor form 2
, urokinase-type plasminogen activator (uPA) receptor
, plasminogen activator urokinase receptor 3
, urinary plasminogen activator receptor 2
, urinary plasminogen activator receptor 3