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Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases
These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha (show HIF1A Proteins) in the EGFR (show EGFR Proteins) endocytosis pathway.
crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface
Here they show that the PH domain from Bcr-Abl (show ABL1 Proteins) binds a number of proteins involved in vital cellular processes in leukemogenesis.
A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2 (show ADRBK1 Proteins)) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 (show PRKCB Proteins) and GRK2 (show ADRBK1 Proteins).
The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported.
Proteins beta3 integrin (show ITGB3 Proteins), Vav3 (show VAV3 Proteins), Plekhm1 (show PLEKHM1 Proteins), and Src (show SRC Proteins), implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis (show CSF1 Proteins).
Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4 (show HSD17B4 Proteins), alpha-actinin (show ACTN1 Proteins), moesin (show MSN Proteins), radixin (show RDX Proteins) and factor XIIIA (show F13A1 Proteins), is proposed.
Targeting of the pleckstrin homology domain of AKT (show AKT1 Proteins) was studied in cancer treatment in mouse models.
pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
Major protein kinase C substrate of platelets.
, platelet 47 kDa protein