Browse our anti-Integrin, alpha 7 (ITGA7) (174869) Antibodies

Mouse (Murine) Integrin, alpha 7 (ITGA7) (174869) interaction partners

1. Ptrh2 (show PTRH2 Antibodies) levels were up-regulated in dystrophin (show DMD Antibodies) deficient mdx (show DMD Antibodies) muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx (show DMD Antibodies) muscle and Duchenne muscular dystrophy (show DMD Antibodies) patients. Similar to the a7 integrin, Ptrh2 (show PTRH2 Antibodies) expression was decreased in laminin-a2 null gastrocnemius muscle

2. Sarcospan (show SSPN Antibodies)-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin (show UTRN Antibodies) and alpha7beta1 integrin.

3. loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan (show SSPN Antibodies)-null mice

4. Integrin alpha 7 integrin beta1 confers a protective effect in dystrophic muscle through the activation of the ILK (show ILK Antibodies), AKT (show AKT1 Antibodies), p70S6K (show RPS6KB1 Antibodies) and BAD signaling to promote muscle cell survival.

5. Up-regulation of integrin alpha 7 expression mediated by TGF-beta 1 (show TGFB1 Antibodies) plays a role in the intraepithelial location of mucosal mast cells in vivo.

6. the interaction of c-Myc (show MYC Antibodies) with the promoter region of Itga7 is an important regulatory element controlling alpha7 integrin expression during muscle development and myotendinous (show TNC Antibodies) junction formation

7. FHL2 (show FHL2 Antibodies) and FHL3 (show FHL3 Antibodies), respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells

8. sarcoglycan (show SGCD Antibodies) and integrin alpha7beta1 have overlapping roles in mediating cytoskeletal-membrane-extracellular matrix interaction

9. Increased in vitro binding of integrin alpha7beta1 to laminin after ADP-ribosylation of the 37-kDa fragment of alpha7 requires the presence of Mn2+ and it is not observed in the presence of Mg2 (show MCOLN1 Antibodies)+

10. deltaEF1 (show ZEB1 Antibodies) has a role in suppressing integrin alpha 7 expression in myoblasts by displacing MYOD (show MYOD1 Antibodies) and competing for p300/CBP (show CREBBP Antibodies) co-activator

Human Integrin, alpha 7 (ITGA7) (174869) interaction partners

1. targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion.

2. Taken together, these results further support the use of a7 integrin as a potential therapy for Duchenne muscular dystrophy (show DMD Antibodies)

3. Data indicate that S100 calcium binding protein P (S100P (show S100P Antibodies)) increased lung cancer cell migration by binding integrin alpha7.

4. Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma.

5. ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3 (show TIMP3 Antibodies)) in prostate cancer cells.

6. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7]

7. Alpha7beta1D integrin modifies Ca2 (show CA2 Antibodies)+ regulatory pathways and offers a means to protect the myocardium from ischemic injury.

8. This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor.

9. ILK (show ILK Antibodies) interaction with MCM7 (show MCM7 Antibodies) and MCM7 (show MCM7 Antibodies) phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression.

10. conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology