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mice lacking alphavbeta5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that alphavbeta5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages
Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3/FAK/AKT signaling pathway.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM.
Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation.
Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration
Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.
Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity.
Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8.
Data suggest that the alphavbeta3 and alphavbeta5 integrins are not essential for mediating microglial activation responses to vitronectin, but that microglia use multiple redundant receptors to mediate interactions with this ECM protein.
Absence of RG2 does not affect the retinal architecture that requires alphavbeta5 integrins.
The exclusive apical distribution of alphavbeta5 integrin receptors in the retinal pigment epithelium, is discussed.
Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
There is a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced acute lung injury.
Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
Alphavbeta5 integrin is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells.
human tumor cells injected s.c. into mice lacking beta3- or beta3/beta5-integrins or various selectins show enhanced tumor growth
Integrin beta 5 knock-out mice demonstrated profoundly accelerated bone loss in the estrogene deplete state.
These results identify alpha(v)beta(5)-integrin as the first RPE receptor that contributes to retinal adhesion, a vital mechanism for long-term photoreceptor function and viability.
analysis of the expression patterns of the alphavbeta3 and alphavbeta5 integrins in mouse developing gonads (10.5-13.5 days post coitum) showed that Beta5 integrin was localized in gonadal somatic cells, with the exception of coelomic epithelial cells.
A function-blocking antibody against the integrin alphavbeta5 prevented development of lung vascular permeability in two different models of acute lung injury.
Our data reveal that the miR-185-ITGB5-beta-catenin pathway plays an important role in HCC tumorigenesis, and ITGB5 may be a promising specific target for HCC therapy.
Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.
High ITGB5 expression is associated with cervical cancer.
Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway.
ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population
FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma.
Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1
FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1
Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes
findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells
we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone
Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin.
molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools.
BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB.
Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells.
The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes.
Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells
integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma
Western blotting showed that ITGbeta5 protein was detectable in bull sperm. Levels of ITGbeta5 were significantly higher in the two-cell embryos, followed by the 8-16-cell embryos. Results reveal that expression of ITGbeta5 in bovine gametes and embryos implies an important role in fertilisation and embryogenesis.
These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
beta chain of integrin\; mouse homolog only forms a heterodimer with alphaV and acts as a vitronectin receptor
integrin, beta 5
, integrin beta 5
, integrin beta-5