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Deletion of ITGA11 in diabetic mice attenuates cardiac fibrosis progression but does not improve cardiac function. Impairments of cardiac function in null mice appear to be due to a novel role of ITGA11 in regulating cardiomyocyte growth and organization and myofibril development.
In NSCLC xenografts in Itga11-knockout mice, collagen cross-linking is associated with stromal alpha11 expression. Loss of tumor stromal alpha11 expression was correlated with decreased collagen reorganization and stiffness.
miR (show MLXIP Proteins)-126a-3p may play a major role in embryo implantation by regulating Itga11, possibly through impairing cell migratory and invasive capacity.
Circulating IGF-1 (show IGF1 Proteins) levels in the sera of mice lacking either alpha2beta1 or alpha11beta1 or both integrins were sharply reduced.
The in vivo indu (show IFNA Proteins)ction of ITGA-11 protein is detected in spleen and lungs of type I IFN-treated BALB/c mice.
analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1
ITGA11 is a highly promising target that is selectively overexpressed in myofibroblasts during fibrotic diseases and regulates myofibroblast differentiation and key phenotypic characteristics.
By employing co-immunoprecipitation and confocal microscopy analysis we showed that integrin alpha11beta1 and protein disulfide isomerase (PDI (show P4HB Proteins)) create complexes bounded by disulfide bonds. Using surface plasmon resonance we provide biochemical evidence that PDI (show PADI1 Proteins) can interact directly with integrin subunit alpha11.
Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2 (show DRD2 Proteins)), rs5744256 (IL-18 (show IL18 Proteins)), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001
FGF2 (show FGF2 Proteins) may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 (show TGFB1 Proteins) mediated ITGA11 expression.
glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 (show TGFB2 Proteins) signaling pathway that stimulates alpha11 integrin expression through Smad2 (show SMAD2 Proteins)/3 binding elements in the alpha11 integrin promoter
Myometrium and uterine fibroids express ITGA11.
Interactions between alpha11 integrins and the Smad (show SMAD1 Proteins)-dependent TGF-beta2 (show TGFB2 Proteins) signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy.
The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2 (show BCL2 Proteins)-associated X protein upregulation.
A new interferon (show IFNA Proteins) stimulated gene. (Integrin alpha 11)
Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth.
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
, integrin alpha-11