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Human CEBPB Protein expressed in Wheat germ - ABIN1349085
Sasaki, Hashimoto, Sawa, Amaya: Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury. in Neuroscience 2014
Nr1d1/Rev-erbalpha (show NR1D1 Proteins) has a direct role in circadian clock regulation of autophagy, which also involves Cebpb/(C/ebpbeta) indirectly in zebrafish
We found that quercetin reduces the promoter activity of apoB (show APOB Proteins), driven by the enforced expression of C/EBPb.
Chromatin immunoprecipitation analysis revealed that C/EBPbeta2 binds to multiple sites at the 5' promoter/regulatory region, introns, and the 3' untranslated region of the IGF-II gene.
C/EBPbeta overexpression or knockdown did not change the levels of IL-1beta (show IL1B Proteins)-induced SOCS1 (show SOCS1 Proteins). SOCS1 (show SOCS1 Proteins) regulated the levels of C/EBPbeta mRNA by ubiquitination of C/EBPbeta as well as transcriptional regulation in human chondrocytes.
C/EBPbeta suppresses miR-17-92 via two pathways - indirectly through induction of PU.1 expression, where it functions as an activator, and more efficiently, through direct interaction with the miR-17-92 promoter.
p300 (show EP300 Proteins)-dependent histone H3 (show HIST3H3 Proteins) acetylation and C/EBPbeta-regulated IKKbeta (show IKBKB Proteins) expression contribute to thrombin (show F2 Proteins)-induced IL-8/CXCL8 (show IL8 Proteins) expression in human lung epithelial cells.
The data suggest that the tumor suppressor activity of both RUNX1t1 (show RUNX1T1 Proteins) and TFF1 (show TFF1 Proteins) are mechanistically connected to CEBPB and that cross-regulation between CEBPB-RUNX1t1 (show RUNX1T1 Proteins)-TFF1 (show TFF1 Proteins) plays an important role in gastric carcinogenesis.
C/EBPbeta negatively regulates PR-B (show PGR Proteins) expression in glioblastoma cells.
High CEBPB expression is associated with recurrence in Glioma.
Study results show the role of WT1 (show WT1 Proteins) in regulating decidualization in human endometrial stromal cells. C/EBPbeta is an upstream gene that regulates WT1 (show WT1 Proteins) expression by binding to the novel enhancer region.
EGFR (show EGFR Proteins) and C/EBP-beta oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta isoform
Studied expression of CD147 in both ALK+ and ALK- anaplastic large-cell lymphoma; found CD147 to be a downstream target for activation by C/EBPbeta.
Data show that in an in vitro acute lung injury model established by lipopolysaccharide induction, phosphorylation of C/EBP beta was decreased and bioinformatics analysis discovered a putative binding site of C/EBP beta in CCSP1 promoter; LPS stimulation reduced C/EBP beta phosphorylation and suppressed the transcription of CCSP1.
Expression of the SENP2 (show SENP2 Proteins) gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 (show TCF20 Proteins) knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta degradation by increasing its sumoylation.
C/EBPbeta is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2 (show NOTCH2 Proteins).
These data establish C/EBPbeta as a key driver of autoimmune inflammation in EAE, and propose a novel role for C/EBPbeta in regulation of IL-23R (show IL23R Proteins) expression.
C/EBPbeta in hematopoietic cells is crucial to regulate diet-induced inflammation, hyperlipidemia and atherosclerosis development
C/EBPbeta or Stat3 (show STAT3 Proteins) depletion by siRNA in sepsis Gr1 (show GSR Proteins)(+)CD11b (show ITGAM Proteins)(+) MDSCs inhibits miR (show MLXIP Proteins)-21 and miR (show MLXIP Proteins)-181b expression.
The present study indicates a requirement for C/EBPbeta in the insulin (show INS Proteins)-mediated induction of SREBP-1c (show SREBF1 Proteins) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha (show NR1H3 Proteins), our data reported herein indicate a requirement for both transcription factors.
elevated LIP/LAP ratio robustly increased Ogn (show OGN Proteins) expression and cell death under stress by modulating the mitogen-activated protein kinase (show MAPK1 Proteins)/activator protein 1 (show JUN Proteins) pathway (MAPK (show MAPK1 Proteins)/AP-1 (show JUN Proteins)).
Ptn (show PTN Proteins) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP (show TMPRSS5 Proteins)-Hand2 (show HAND2 Proteins) signaling.
C/EBPbeta is a critical factor for Ly6C(-) monocyte survival, at least in part through upregulation of Csf1r (show CSF1R Proteins).
C/EBP-beta plays a vital role in regulating GPR120 transcription.
The expression of porcine Prdx6 (show PRDX6 Proteins) gene is up-regulated by C/EBPbeta and CREB (show CREB1 Proteins).
Results show that expression changes of IGF1 (show IGF1 Proteins) genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.
FoxO1 (show FOXO1 Proteins) and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1 (show FOXO1 Proteins)-> C/EBPb feedback regulatory loop and FoxO1 (show FOXO1 Proteins)-C/EBPb protein complex.
the pig GPD1 (show GPD1 Proteins) gene is regulated negatively by C/EBP beta in cultured kidney cells
GATA-4 (show GATA4 Proteins) and C/EBPbeta are both required for FSH (show BRD2 Proteins) +/- IGF-I (show IGF1 Proteins) stimulation of the porcine steroidogenic acute regulatory protein (show STAR Proteins) gene promoter in homologous granulosa cell cultures.
The differential expression of specific CEBPA (show CEBPA Proteins)/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
SREBP1a activated while C/EBP (show CEBPA Proteins) factors downregulated the activity of the SCD1 (show SCD Proteins) promoter.
These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related (show SYCE2 Proteins) genes expression and function of bovine SCs (show TWIST1 Proteins).
Suppression of CPT1B (show CPT1B Proteins) and induction of SCD (show SCD Proteins) and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma (show PPARG Proteins) gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Proteins) gene expression in adipocytes.
Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
The 3' terminal end of the first intron of porcine SPP1 (show SPP1 Proteins) harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
2-chloroethyl ethyl sulfide (show SQRDL Proteins) exposure caused a 2.3-fold increase in the activation of C/EBP (show CEBPA Proteins) accompanied with a 45% and 121% increase in the protein level of C/EBP beta and ICAM-1 (show ICAM1 Proteins), respectively, and this effect was counteracted by the antioxidant liposome.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
CCAAT/enhancer binding protein (C/EBP), beta
, CCAAT/enhancer-binding beta protein b
, CCAAT/enhancer-binding protein beta
, CCAAT/enhancer binding protein beta
, interleukin 6-dependent DNA-binding protein
, liver-enriched transcriptional activator protein
, nuclear factor NF-IL6
, nuclear factor of interleukin 6
, transcription factor 5
, C/EBP BETA
, interleukin-6-dependent-binding protein
, liver-enriched transcriptional activator
, nuclear protein Il6
, C/EBP beta
, c/EBP-related protein 2
, liver activating protein (LAP)
, nuclear factor-IL6
, silencer factor B
, c/EBP beta
, CCAAT box/enhancer binding protein beta
, CCR protein
, transcription factor NF-M