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Human IRF1 Protein expressed in Wheat germ - ABIN1308073
Liu, Khachigian et al.: Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and ... in The Journal of biological chemistry 2009
Following spring viremia of carp (show ANKRD1 Proteins) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Proteins) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Proteins)-dependent regulatory mechanism fine-tuning IFN gene activation.
IRF-1 regulates Rab27a transcription and extracellular vesicles secretion, leading to oxidized phospholipids activation of neutrophils and subsequent hepatic IR injury
Down-regulation of interferon regulatory factor 1 gene expression in hepatitis B virus patients without rejection emphasized counteraction between hepatitis B virus replication and interferon regulatory factor 1 production. On the other hand, interferon regulatory factor 1 gene overexpression in patients with rejection may result in inflammatory reactions and ischemic-reperfusion injury.
IRF-1 polymorphisms influence the risk for childhood allergic asthma being associated with increased pro-inflammatory gene regulation.
IRF1 served as tumor suppressor in the regulation of cholangiocarcinoma cells proliferation, cell cycle, migration and invasion
this study shows that IRF-1 is a regulator of lipopolysaccharide -induced endothelial proinflammatory activation
These results revealed that IRF-1 is involved in the IFN-inducible expression of Nmi (show MYO1C Proteins).
our results indicated that IL-1beta (show IL1B Proteins) treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human osteoarthritis treatment
The authors observe that IRF1 expression is mediated by ZEB1 de-repression, and the study demonstrates how airway remodelling/fibrosis is associated with a defective mucosal antiviral response through ZEB1-initiated epigenetic silencing in respiratory virus infection.
These unprecedented data suggest that IRF1 and NF-kappaB (show NFKB1 Proteins) orchestrate the TLR4 (show TLR4 Proteins)-primed immunomodulatory response of hMSCs and that this response also involves the PI3K (show PIK3CA Proteins) pathway.
Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 (show FOXP3 Proteins) and KLF-10 and downregulation of IRF-1.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 regulates Rab27a transcription and extracellular vesicles secretion, leading to oxidized phospholipid activation of neutrophils and subsequent hepatic ischemia reperfusion injury.
Low IRF1 expression is associated with lymphoma.
Knockout of IRF-1 decreased expression and release of HMGB1 (show HMGB1 Proteins) in liver, and inhibiting the release of HMGB1 (show HMGB1 Proteins) could alleviate hepatic ischemia-reperfusion injury.
IRF-1 may be a critical factor in augmenting LPS (show TLR4 Proteins)-induced oxidative stress and mitochondrial damage in macrophages.
IRF-1 plays a key role in controlling caspase-1 (show CASP1 Proteins)-dependent pyroptosis and inflammation.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (show HCFC2 Proteins) is a critical component of the IRF1 and IRF2 (show IRF2 Proteins) transcriptional machinery that regulates Tlr3 (show TLR3 Proteins) gene expression.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (show MLXIP Proteins)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (show SOCS5 Proteins)).
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 (show TXNRD1 Proteins) gene network in response to IL-27 (show IL27 Proteins) signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 (show TXNRD1 Proteins) lineage.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1