Browse our anti-Arrestin 3 (ARRB2) Antibodies

Human Arrestin, beta 2 (ARRB2) interaction partners

1. overexpression of beta-arrestin2 can inhibit the growth of renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) cells in vitro, and beta-arrestin2 acts as a tumor suppressor gene in RCC (show XRCC1 Antibodies); the main mechanism may directly suppress the phosphorylation of IkBa (show NFKBIA Antibodies) and indirectly suppress NFkB

2. Study investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to antidepressant treatment in a sample of 569 patients with a major depressive episode treated for 6months: GG/GT patients for rs4522461 and AA/AC patients for rs4790694 had a lower response.

3. Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-link (show SUFUH Antibodies)ed polyubiquitylation without affecting its stability.

4. These data highlight a novel arrestin (show SAG Antibodies)-mediated modulation of CREB (show CREB1 Antibodies) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (show ADRB2 Antibodies) to activate prolonged CREB (show CREB1 Antibodies) phosphorylation by precluding recruitment of an arrestin2/Src (show SRC Antibodies)/p38 (show CRK Antibodies) complex.

5. A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.

6. USP33 (show USP33 Antibodies) may indirectly regulate the degradation and recycling of CXCR4 (show CXCR4 Antibodies) through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.

7. Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R (show HRH1 Antibodies).

8. the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified.

9. Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.

10. Data indicate that a constitutively monomeric CXCL12 (show CXCL12 Antibodies) variant reproduced the G protein-dependent and beta-arrestin-dependent responses that are associated with normal CXCR4 (show CXCR4 Antibodies) signaling and lead to cell migration.

Cow (Bovine) Arrestin, beta 2 (ARRB2) interaction partners

1. The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.

2. K2A mutations in arrestin-1 (show SAG Antibodies), -2, and -3 significantly reduced their binding to active phosphorhodopsin.

3. Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.

Mouse (Murine) Arrestin, beta 2 (ARRB2) interaction partners

1. these results suggest that beta-arrestin2 down-regulation increases hepatocellular carcinoma cell migration and invasion ability

2. beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu (show SUFUH Antibodies)

3. Our data reveal beta-arrestin 1 (show ARRB1 Antibodies), beta-arrestin 2, and AT1R (show AGTRAP Antibodies) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Antibodies)+) sensitivity.

4. Arrestin (show SAG Antibodies) beta2 deficiency-mediated intestinal progenitor/stem cell radioprotection relied on protracted NF-kappaB (show NFKB1 Antibodies) activation and subsequent suppression of PUMA (show BBC3 Antibodies) induction.

5. GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling.

6. beta-arrestin2-biased negative modulators of mGlu5 (show GRM5 Antibodies) offer significant advantages over first-generation inhibitors for the treatment of fragile X (show FMR1 Antibodies) and related disorders.

7. selective inactivation of the GPCR (show GPBAR1 Antibodies)-associated protein beta-arrestin 2 in hepatocytes of adult mice results in greatly increased hepatic GCGR (show GCGR Antibodies) signaling, leading to striking deficits in glucose homeostasis

8. AT1R (show AGTRAP Antibodies)-beta-arrestin-2 pathway signaling plays an important role in renal fibrosis.

9. These data suggest that one allele of arrestin-2 (show ARRB1 Antibodies) is unable to support normal locomotor behavior due to signaling and/or developmental defects.

10. Beta-arrestin-2 with beta-arrestin-1 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.

Xenopus laevis Arrestin, beta 2 (ARRB2) interaction partners

1. Arrb2 physically interacts with the beta subunit (show POLG Antibodies) of trimeric G-proteins and Dishevelled (show DVL2 Antibodies), the interaction between arrb2 and Dishevelled (show DVL2 Antibodies) is promoted by the beta/gamma subunits of trimeric G-proteins.

Zebrafish Arrestin, beta 2 (ARRB2) interaction partners

1. results suggest that a functional interaction between beta-arrestin 2 and Smoothened (show SMO Antibodies) may be critical to regulate hedgehog (show SHH Antibodies) signaling in zebrafish development