Browse our anti-Arrestin 3 (ARRB2) Antibodies

Human Arrestin, beta 2 (ARRB2) interaction partners

1. Beta-arrestin interacting with unphosphorylated ADRB2 (show ADRB2 Antibodies) fails to activate mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling and prolonged interaction of beta-arrestin with ADRB2 (show ADRB2 Antibodies) promoted the sorting of ADRB2 (show ADRB2 Antibodies) to lysosomes.

2. Pre-treatment with beta-arrestin2 agonists was shown to inhibit the AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway, and to inhibit autophagy by restoring the levels of beta-arrestin2 in BEAS-2B cells. These changes were reversed with the knockdown of beta-arrestin2, indicating that beta-arrestin2 suppressed autophagy through the AMPK (show PRKAA1 Antibodies)-mTOR (show FRAP1 Antibodies) signaling pathway.

3. Extracellular alpha-synuclein induces sphingosine S1P1R uncoupled from inhibitory G-protein leaving beta-arrestin signal intact.

4. These results show that b-arrestin1 (show SAG Antibodies) and b-arrestin2 exert differential actions on PAC1R (show ADCYAP1R1 Antibodies) internalization and PAC1R (show ADCYAP1R1 Antibodies)-dependent ERK1/2 activation, and suggest that the two b-arrestin (show SAG Antibodies) isoforms may be involved in fine and precise tuning of the PAC1R (show ADCYAP1R1 Antibodies) signaling pathways.

5. overexpression of beta-arrestin2 can inhibit the growth of renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) cells in vitro, and beta-arrestin2 acts as a tumor suppressor gene in RCC (show XRCC1 Antibodies); the main mechanism may directly suppress the phosphorylation of IkBa (show NFKBIA Antibodies) and indirectly suppress NFkB

6. Study investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to antidepressant treatment in a sample of 569 patients with a major depressive episode treated for 6months: GG/GT patients for rs4522461 and AA/AC patients for rs4790694 had a lower response.

7. Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-link (show SUFUH Antibodies)ed polyubiquitylation without affecting its stability.

8. These data highlight a novel arrestin (show SAG Antibodies)-mediated modulation of CREB (show CREB1 Antibodies) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (show ADRB2 Antibodies) to activate prolonged CREB (show CREB1 Antibodies) phosphorylation by precluding recruitment of an arrestin2/Src (show SRC Antibodies)/p38 (show CRK Antibodies) complex.

9. A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.

10. USP33 (show USP33 Antibodies) may indirectly regulate the degradation and recycling of CXCR4 (show CXCR4 Antibodies) through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.

Cow (Bovine) Arrestin, beta 2 (ARRB2) interaction partners

1. The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.

2. K2A mutations in arrestin-1 (show SAG Antibodies), -2, and -3 significantly reduced their binding to active phosphorhodopsin.

3. Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.

Mouse (Murine) Arrestin, beta 2 (ARRB2) interaction partners

1. GPCR (show GPBAR1 Antibodies)-arrestin (show SAG Antibodies) complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels.

2. Spinal Arrb2 may serve as an intracellular gate for acute to chronic pain transition via desensitization of NMDAR (show GRIN1 Antibodies).

3. Knockout of mice beta-arrestin2, but not beta-arrestin1 (show ARRB1 Antibodies), results in deficits in plasticity mediated by mGlu1 (show GRM1 Antibodies) receptors in CA3 (show CA3 Antibodies) pyramidal neurons and by mGlu5 (show GRM5 Antibodies) receptors in CA1 (show CA1 Antibodies) pyramidal neurons.

4. beta-arrestin 2 can protect liver tissue from LPS (show TLR4 Antibodies)-induced injury via inhibition of TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling pathway-mediated inflammation.

5. Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.

6. Arrb2 induces cardiomyocyte death by interacting with the p85 subunit of PI3K, and negatively regulating the formation of p85-PI3K/CaV3 survival complex, thus blocking activation of PI3K-Akt-GSK3beta cell survival signalling pathway in cardiac ischemia-reperfusion.

7. these results suggest that beta-arrestin2 down-regulation increases hepatocellular carcinoma cell migration and invasion ability

8. beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu (show SUFUH Antibodies)

9. Our data reveal beta-arrestin 1 (show ARRB1 Antibodies), beta-arrestin 2, and AT1R (show AGTRAP Antibodies) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Antibodies)+) sensitivity.

10. Arrestin (show SAG Antibodies) beta2 deficiency-mediated intestinal progenitor/stem cell radioprotection relied on protracted NF-kappaB (show NFKB1 Antibodies) activation and subsequent suppression of PUMA (show BBC3 Antibodies) induction.

Xenopus laevis Arrestin, beta 2 (ARRB2) interaction partners

1. Arrb2 physically interacts with the beta subunit (show POLG Antibodies) of trimeric G-proteins and Dishevelled (show DVL2 Antibodies), the interaction between arrb2 and Dishevelled (show DVL2 Antibodies) is promoted by the beta/gamma subunits of trimeric G-proteins.

Zebrafish Arrestin, beta 2 (ARRB2) interaction partners

1. results suggest that a functional interaction between beta-arrestin 2 and Smoothened (show SMO Antibodies) may be critical to regulate hedgehog (show SHH Antibodies) signaling in zebrafish development