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retinoblastoma RB1 -/- cells cannot survive in the absence of MED4, both in vitro and in orthotopic xenograft models in vivo, therefore identifying MED4 as a survival gene in retinoblastoma.
Our findings suggest that Vitamin D Receptor polymorphisms may be associated with nasal carriage of S. aureus in individuals with type 1 diabetes.
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
mediator of RNA polymerase II transcription subunit 4
, TRAP/SMCC/PC2 subunit p36
, activator-recruited cofactor 36 kDa component
, mediator, 34-kD subunit, homolog
, vitamin D receptor-interacting protein, 36-kD
, vitamin D3 receptor-interacting protein complex 36 kDa component
, mediator of RNA polymerase II transcription, subunit 4 homolog
, vitamin D receptor interacting protein
, mediator complex subunit 4
, p36 TRAP/SMCC/PC2 subunit