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Disruption of a nuclear co-repressor of catabolism, the Nrip1 gene, in white adipocytes enhanced adipocyte browning with a marked increase of uncoupling protein 1 expression.
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this preliminary report indicates that the ERbeta/RIP140 signaling is altered in unifocal breast cancers and correlated with patient outcome.
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Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes.
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In skeletal muscle, imposed rest increased NRIP1 expression by 80%, and strength training increased expression by 25% compared to baseline. Following rest, NRIP1 expression became sensitive to insulin stimulation. After re-training, NRIP1 expression decreased. Interactome analysis showed significant proximity of NRIP1 interacting partners to the obesity network/module.
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Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells.
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Study found low expression level of RIP140 in tumor-associated macrophages (TAM) of hepatocellular carcinoma (HCC) tissues and demonstrated that RIP140 expression in plays a role in the growth of hepatoma cells.
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results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1.
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Data indicate that nuclear receptor interacting protein 1 (NRIP1) is elevated in tumors compared to cancer adjacent normal tissue.
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NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway.
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NRIP1 contributes to the mitochondrial dysfunction observed in DS. Furthermore, they suggest that the NRIP1-PGC-1alpha axe might represent a potential therapeutic target for restoring altered mitochondrial function in DS.
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RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition
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Downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro.
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Data suggest that vitamin D receptor target genes (NRIP1; DUSP10, dual specificity phosphatase 10; THBD, thrombomodulin; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements.
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RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1.
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The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population.
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data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment
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In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels.
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RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression.
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these data demonstrate the inhibitory effects of ERbeta on estrogen signaling in ovarian cancer cells and the key role that RIP140 plays in this phenomenon.
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Estrogen receptors alpha and beta and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules.
