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High RNF6 expression is associated with breast cancer.
This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 (show PBX1 Proteins) and that the PBX1 (show PBX1 Proteins)/RNF6 axis can be developed as a novel therapeutic target of leukemia.
Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics
Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2 (show PLP1 Proteins), in human development.
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
E3 ubiquitin-protein ligase RNF6
, RING-H2 protein RNF-6
, RLIM-like protein
, RING finger protein 6
, ring finger protein 6