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The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
E3 ubiquitin-protein ligase RNF6
, RING-H2 protein RNF-6
, RLIM-like protein
, RING finger protein 6
, ring finger protein 6