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anti-Human TCF21 Antibodies:
anti-Mouse (Murine) TCF21 Antibodies:
anti-Rat (Rattus) TCF21 Antibodies:
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Human Polyclonal TCF21 Primary Antibody for IHC, IHC (p) - ABIN4358092
Sazonova, Zhao, Nürnberg, Miller, Pjanic, Castano, Kim, Salfati, Kundaje, Bejerano, Assimes, Yang, Quertermous: Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. in PLoS genetics 2015
Show all 2 Pubmed References
TCF21 expression was decreased in HCC patients and it could act as a prognostic marker
Authors propose that the pro-differentiation action of SMAD3 inhibits dedifferentiation that is required for HCASMC to expand and stabilize disease plaque as they respond to vascular stresses, counteracting the protective dedifferentiating activity of TCF21 and promoting disease risk.
The study revealed that restoration of TCF21 expression in 786-O clear cell renal cell carcinoma cell line results in decreased clonogenic proliferation and migration.
TCF21 inhibits gastric cancer growth and chemoresistance possibly through the AKT signaling pathway
we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma.
TCF21 is downregulated in ESCC, and its low expression is closely correlated with N stage and predicts a poor prognosis. TCF21 functions as a tumor suppressor in ESCC progression, and enhancement of its expression levels may be partly through promoting Kiss-1 expression to reverse EMT by modulating EMT-related gene expression.
TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells.
TCF21, a hypoxia-driven p53 target, functions as a tumor suppressor in uterine corpus endometrial cancer and presents as a therapeutic target for tumor treatment.
Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes.
TCF21 rs12190287 polymorphism can regulate TCF21 expression and may serve as a potential marker for genetic susceptibility to breast cancer.
There were significant differences in the genotype and allele frequencies of rs12190287 between the cases and controls in a Chinese population. Allele G of rs12190287 was significantly associated with an increased risk of Ventricular Septal Defects in a Chinese population.
Transcription Factor 21 is downregulated in adrenocortical carcinoma cells. Taken together, these findings support the hypothesis that Transcription Factor 21 is a regulator of steroidogenic factor 1 and is a tumor suppressor gene in pediatric and adult adrenocortical tumors.
TCF21 binds to AHR, promotes expression of AHR to upregulate inflammation-related genes in coronary artery smooth muscle.
Association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population.
These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis.
TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC development.
The presence of significant hypermethylation of TCF21 supports the hypothesis that hypermethylation of TCF21 and/or decreased TARID expression lies within the pathogenic pathway of most CCSKs.
our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT.
Separate enrichment analyses found over-representation of TCF21 target genes among CAD associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci consistent with the hypothesis that TCF21 may affect disease risk
TCF21 could inhibit the proliferation and migration of SMMC-7721 hepatocellular carcinoma cells and promote its apoptosis
findings indicate that Tcf21 has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development and suggest that Tcf21 regulates key molecular pathways required for branching morphogenesis
Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction.
These results suggest that TCF21 contributes to the proinflammatory environment in VIS fat depots and to active ECM remodeling of these depots by regulating IL6 expression and MMP-dependent ECM remodeling in a spatiotemporally coordinated manner.
Periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage and are necessary for adaptive healing and fibrosis.
During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21-LacZ + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
TCF21 may have a role regulating the differentiation state of SMC precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human Coronary Artery Disease
Our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes.
Data indicate that loss of Pod1/Tcf21 leads to epicardial blistering, increased smooth muscle cell differentiation on the surface of the heart, and a paucity of interstitial fibroblasts, with neonatal lethality.
The majority of Tcf21-expressing epicardial cells are committed to the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition.
Data show that correct levels of expression of Myf5 and MyoD during mouse craniofacial development result from activation by musculin and TCF21 through direct binding to specific enhancers.
epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation
findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles
cell autonomous and non-cell autonomous roles for Pod1 in the differentiation of specific renal cell lineages that include peritubular interstitial cells and pericytes.
Essential for gonadal development, part of a transcriptional network that orchestrates cell fate decisions in gonadal progenitors.
Pod-1, which controls androgen receptor transcription and function, may play an important role in the development and function of the testis.
Identificaation of differentially expressed genes in glomeruli from Pod1 knockout (KO) mice that die in the perinatal period with multiple renal defects
analysis of TCF21 epigenetic regulation in experimental lung and head and neck cancer
Pod1 increased E2A binding to a calponin promoter E-box sequence. Overexpression of Pod1 & E2A resulted in increased smooth muscle and myofibroblast gene expression including calponin, SM22alpha, alphaSMA, fibronectin, & connective tissue growth factor.
The data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation.
Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium
Distribution of a basic helix-loop-helix transcription factor expressed very early in the development of the pronephric glomus is described.
Capsulin has an essential role in zebrafish craniofacial myogenesis.
Upstream sequences of the transcription factor gene tcf21 activate robust, epicardium-specific expression throughout development and regeneration.
Endogenous Capsulin was distributed mainly in the epicardial cells of zebrafish.
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.
, class A basic helix-loop-helix protein 23
, podocyte-expressed 1
, Pod 1
, Podocyte-expressed 1
, transcription factor 21
, pod 1
, Transcription factor 21