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Chicken Monoclonal UBE2I Primary Antibody for IF, IP - ABIN968155
Buschmann, Lerner, Lee, Ronai: The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9. in The Journal of biological chemistry 2001
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Chicken Monoclonal UBE2I Primary Antibody for IF, IP - ABIN968154
Kovalenko, Plug, Haaf, Gonda, Ashley, Ward, Radding, Golub: Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 4 Pubmed References
Human Monoclonal UBE2I Primary Antibody for WB - ABIN387788
Moschos, Jukic, Athanassiou, Bhargava, Dacic, Wang, Kuan, Fayewicz, Galambos, Acquafondata, Dhir, Becker: Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. in Human pathology 2010
Show all 7 Pubmed References
Human Polyclonal UBE2I Primary Antibody for IHC (p), WB - ABIN387910
Watanabe, Fujiwara, Kawai, Shimizu, Takami, Hirano, Okuno, Ozaki, Takeda, Shimada, Nagata, Takaichi, Takahashi, Nakamura, Shin: Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. in Cytogenetics and cell genetics 1996
Show all 3 Pubmed References
Human Polyclonal UBE2I Primary Antibody for ICC, IF - ABIN268538
Uemura, Taniguchi, Matsuo, Oku, Wakabayashi, Yoshida: UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress response. in Cell structure and function 2013
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Human Monoclonal UBE2I Primary Antibody for ICC, FACS - ABIN969451
Mohideen, Capili, Bilimoria, Yamada, Bonni, Lima: A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. in Nature structural & molecular biology 2009
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Analysis of protein interactions showed that K179A, K180A, and K221A substitutions of classical swine fever virus core protein disrupt core-SUMO-1 (show SUMO1 Antibodies) binding, while K220A substitution precludes core-UBC9 binding.
TBX-2 (show TBX2 Antibodies) and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 (show TBX2 Antibodies) function requires sumoylation.
NUSAP1 (show NUSAP1 Antibodies) contributes to accurate chromosome segregation by acting as a co-factor for RanBP2 (show RANBP2 Antibodies)-RanGAP1 (show RANGAP1 Antibodies)-UBC9 during cell division.
Listeriolysin O -induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling.
Sumoylation of PML (show PML Antibodies) with SUMO2 (show SUMO2 Antibodies) by UBC9/UBE2I can lead to formation of polymeric SUMO chains. Data suggest that coordination of growing poly-SUMO chain with "back side" binding site on UBC9/UBE2I appears to be required for SUMO chain elongation on PML (show PML Antibodies). (PML (show PML Antibodies) = promyelocytic leukemia protein (show PML Antibodies); SUMO2 (show SUMO2 Antibodies) = small ubiquitin-like modifier 2 (show SUMO2 Antibodies); UBC9/UBE2I = ubiquitin-conjugating enzyme (show Ube2t Antibodies) UBC9/UBE2I)
The role of Transthyretin (show TTR Antibodies) in the regulation of Ubc9 SUMOylation
These findings point to UBC9 and autophagy as novel hallmarks of human papillomavirus oncogenesis
These findings reveal that SUMO E1~E2 oxidation is an essential redox switch in oxidative stress.
the mRNA and protein expression of Ubc9 are regulated by the microRNA miRNA-30a (miR (show MLXIP Antibodies)-30a) in human subcutaneous adipocytes.
miR-30e in VSMCs exerted an anti-atherosclerosis effect via inhibiting proliferation and migration, and promoting apoptosis of VSMCs. More specifically, it was demonstrated that miR-30e exhibited these effects on VSMCs partially through targeting Ube2i and downregulating the IkappaBalpha/NFkappaB signaling pathway.
Ubc9 plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase (show BLMH Antibodies) and poly(ADP-ribose) polymerase-1 (show PARP1 Antibodies). The results are beneficial to deeply understanding of Ubc9 functions and for precise prediction of chemotherapy outcomes in tumors.
Suggest a novel role of PCGF2 (show PCGF2 Antibodies) in arsenic trioxide-mediated degradation of PML (show PML Antibodies)-RARA (show RARA Antibodies) that PCGF2 (show PCGF2 Antibodies) might act as a negative regulator of UBE2I via direct interaction.
These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.
this study shows that loss of Ubc9 results in a significant reduction of CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) single-positive lymphocytes in both thymus and periphery
Increased UBC9-mediated SUMOylation is sufficient to upregulate cardiac autophagy. UBC9 overexpression reduced aggregate formation, decreased fibrosis, reduced hypertrophy, and improved cardiac function and survival.
The study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of alpha-Synuclein.
Synaptic trapping of Ubc9 through a PKC (show PKC Antibodies) phosphorylation-dependent increase of Ubc9 recognition to phosphorylated substrates and consequently leads to the modulation of synaptic sumoylation.
UBC9 has a role in promoting proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis
the sole SUMO E2 enzyme Ubc9 plays a critical role in reprogramming fibroblasts to iPS cells and maintaining ESC pluripotency.
Data indicate that knockdown of ubiquitin-conjugating enzyme 9 (UBC9) by small interfering RNA caused significant accumulations of aggregated protein.
Ubc9 negatively regulates osteoblastic differentiation induced by BMP.
expressed Ubc9 at modestly increased levels showed robust resistance to brain ischemia compared to wild type mice
These data indicate an in vivo requirement of Ubc9 for G2/M transition and/or progression through mitosis during vertebrate organogenesis.
Chromosomal assignment of the bovine ubiquitin-conjugating enzyme E2I (UBE2I ) gene to BTA6q34 defines a new fragment of conserved synteny with human chromosome 16.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
, SUMO-conjugating enzyme UBC9
, SUMO-protein ligase
, ubiquitin carrier protein 9
, ubiquitin carrier protein I
, ubiquitin conjugating enzyme 9
, ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
, ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
, ubiquitin-conjugating enzyme UbcE2A
, ubiquitin-like protein SUMO-1 conjugating enzyme
, ubiquitin-protein ligase E2I
, ubiquitin-protein ligase I
, SUMO-conjugating enzyme UBC9-A
, SUMO-protein ligase A
, ubiquitin carrier protein 9-A
, ubiquitin carrier protein I-A
, ubiquitin-conjugating enzyme 9
, ubiquitin-conjugating enzyme E2 I-A
, ubiquitin-protein ligase I-A
, ubiquitin-conjugating enzyme E2L
, ubiquitin-conjugating enzyme E2I
, SUMO-1 conjugating enzyme
, Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9)
, ubiquitin-conjugating enzyme E2 I
, ubiquitin-conjugating enzyme E2I (UBC9 homolog)
, Ubiquitin carrier protein 9
, Ubiquitin carrier protein I
, Ubiquitin-conjugating enzyme E2 I
, Ubiquitin-protein ligase I
, ubiquitin conjugating enzyme