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Results show that YWHAZ (show YWHAZ Proteins) amplification indicates a better survival trend in bladder cancer. Its knockdown promotes both in vitro and in vivo tumorigenesis in bladder cancer and may be a novel biomarker for bladder cancer.
The impact of AKT1 (show AKT1 Proteins) on glucocorticoid receptor (GR (show NR3C1 Proteins))-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (show YWHAQ Proteins), was examined.
14-3-3 eta isoform colocalizes TDP-43 (show TARDBP Proteins) on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
This study identified YWHAH significantly associated loci with a biologically plausible role in schizophrenia.
This is the first genetic association study of YWHAH with sporadic Creutzfeldt-Jakob disease populations.
Data indicate that gene analysis revealed an up-regulation of all four 14-3-3 (show YWHAQ Proteins) isoforms beta, eta, gamma, and sigma.
relocation of p33ING1b (show ING1 Proteins) from the nucleus to the cytoplasm, where the protein is tethered by 14-3-3eta, participates in tumorigenesis and progression in HNSCC
The 14-3-3 eta, beta, gamma and sigma isoforms were negatively expressed in meningioma
14-3-3beta, 14-3-3gamma, 14-3-3epsilon, 14-3-3eta and 14-3-3theta isoforms interact with the GPIb-IX complex in platelets
Results show that three 14-3-3 (show YWHAQ Proteins) isoforms, beta, gamma and eta, are DAL-1 (show EPB41L3 Proteins)/Protein 4.1B (show EPB41L3 Proteins)-binding proteins.
These results suggest that 14-3-3 eta has a protective role against mitochondria mediated cardiomyocyte apoptosis with the involvement of Ask-1 (show MAP3K5 Proteins)/JNK (show MAPK8 Proteins) signaling during high fat diet induced type 2 diabetes mellitus.
The myocardial NF-kappaB (show NFKB1 Proteins) activation, inhibitor of kappa B-alpha degradation and mRNA expression of proinflammatory cytokines were significantly increased in DN 14-3-3 (show YWHAQ Proteins) mice compared to WT mice.(14-3-3 protein eta)
Inhibition of a single protective isoform, 14-3-3theta;, by shRNA did not increase vulnerability to neurotoxic injury, but toxicity was enhanced by broad-based inhibition of 14-3-3 (show YWHAQ Proteins) action with the peptide inhibitor difopein.
14-3-3 eta plays a regulatory role in chondrogenic differentiation.
Targeting of dominant-negative 14-3-3eta (DN-14-3-3 (show YWHAQ Proteins)) to murine postnatal cardiac tissue potentiates Ask1 (show MAP3K5 Proteins), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (show MAPK14 Proteins) (MAPK (show MAPK1 Proteins)) activation
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.
tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide
, 14-3-3 eta
, 14-3-3 protein eta
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
, protein kinase C inhibitor protein 1
, tyrosine 3-monooxygenase/tryotophan 5-monooxygenase activation protein
, 14-3-3 protein eta-subtype