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Because RPL23 is encoded by a target gene of c-Myc, the RPL23/Miz-1/c-Myc regulatory circuit provides a feedback loop that links efficient RPL23 expression with c-Myc's function to suppress Miz-1-induced Cdk inhibitors and thereby leads to apoptotic resistance in higher-risk myelodysplastic syndrome patients
This study firstly associates ZBTB17 loss-of-function mutation with enhanced susceptibility to DCM in humans, which provides novel insight into the molecular mechanism underpinning DCM, implying potential implications for genetic counseling and personalized management of DCM
These data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression via its interaction with MIZ1.
strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported
Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation.
The mechanism of inhibition of c-Myc transcriptional activity by Miz-1 that binds c-Myc while competing for binding with Max has been described.
This study used NMR to deduce the role of Miz-1 Zinc Fingers 1-4 in detecting the Miz-1 consensus sequence and preventing nonspecific DNA binding.
the silencing of Miz-1 expression inhibited cell proliferation and promoted apoptosis in vitro and reduced the migration ability in esophageal carcinoma cells.
This study presents the structure of the synthetic Miz-1 Zinc Finger 13 determined by 2D (1)H-(1)H NMR.
results indicate that Miz-1 may be directed in vivo to the novel motif sequences we have identified, where it can recruit its specific binding partners to control gene expression and ultimately regulate cell fate
MIZ-1 can promote the proliferation of breast cancer cells through Wnt signaling.
We demonstrate that Arnt is an interaction partner for Miz-1, and that Arnt has a functional role in the regulation of CDKN2B
The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC.
The ZBTB17 polymorphism rs10927875 appears to play a role in the susceptibility of the Han Chinese population to dilated cardiomyopathy .
The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation.
study demonstrate that HPV-16 E7 forms a complex with Miz-1; These findings suggest that HPV-16 E7 protein can repress Miz-1-induced p21(Cip1) gene expression
NLRR3 is a direct target of MYCN, which associates with Miz-1 and negatively regulates NLRR3 expression.
Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability.
The ribosomal protein L23 is a negative regulator of Miz1-dependent transactivation.
These results identify an important function for BCL6 in facilitating apoptosis of germinal center B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis.
rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1, to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context.
the Myc/Miz1 interaction is a defining hallmark of Sonic Hedgehog medulloblastomas development
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Miz1 plays an essential role in myelin homeostasis of peripheral nerves.
The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian cancer.
Conditional knockout of the Miz1 POZ domain in luminal cells during pregnancy caused a lactation defect with a transient reduction of glandular tissue, reduced proliferation and attenuated differentiation.
Miz1 may link cell growth and ribosome biogenesis to the transcriptional regulation of vesicular transport and autophagy.
Miz1 as a novel regulator in the Hedgehog protein signal pathway that plays an important role in mediating Smo-dependent oncogenic signaling.
data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc/Miz1 complexes that mediates p21 and p15 down-regulation
this study reports that the transcription factor Miz1 was required for terminating lipopolysaccharide (LPS)-induced inflammation.
Our data demonstrate that Miz1-mediated attenuation of cell cycle arrest pathways via repression of cdkn1a has a critical role during tumorigenesis in the skin.
We propose that Miz-1 is a critical factor for the pre-T cell beta-selection checkpoint
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Myc represses C/EBPdelta expression by associating with the C/EBPdelta proximal promoter as a transient component of a repressive complex that includes Max and Miz1
Binding of Myc to Miz1 is continuously required to repress CKI expression and inhibit accumulation of trimethylated histone H3 at Lys 9 (H3K9triMe), a hallmark of cellular senescence, in T-cell lymphomas
The gene encoding Zfp100 has been assigned to murine chromosome 4 band D3/E1.
analysis of gene regulatory interplay between TBP, PIAS1, PIAS3, PIASx, PIASy, ZFP523, and transcription factors
Our data show that Miz1 is involved in controlling proliferation and differentiation in hair follicles and in hair fiber morphogenesis.
transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppresses TNF-alpha-induced JNK1 activation and cell death independently.
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18.
Myc-interacting Zn finger protein-1
, myc-interacting zinc finger protein 1
, zinc finger and BTB domain-containing protein 17
, zinc finger protein 151 (pHZ-67)
, zinc finger protein 60
, polyomavirus late initiator promoter-binding protein
, zinc finger protein 100
, zinc finger protein 151
, zinc finger protein Z13