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Unfavorable genotype of polymorphic variants of candidate gene participating in endothelial dysfunction AGT (show AGXT Proteins) (Thrl74Met and Met23SThr) was associated with changes in levels of their active substances in individuals exposed to mercury.
These findings reveal the critical role of hypoxia in producing local angiotensin II by a lactate-chymase (show CMA1 Proteins)-dependent mechanism and highlight the importance of local angiotensin II in regulating radioresistance of hypoxic tumor cells.
The reduced urinary AGT (show AGXT Proteins)/creatinine in Autralian Indigenous pregnant women may reflect subclinical renal dysfunction which limits the ability of the kidney to maintain sodium balance and could indicate an increased risk of pregnancy complications and/or future renal disease.
ACE2 (show ACE2 Proteins) and other enzymes can form ANG-(1 (show ANGPT1 Proteins)-7) directly or indirectly from either the decapeptide ANG I or from ANG II. [review]
The ACE (show ACE Proteins) and AGT (show AGXT Proteins) gene polymorphisms are not associated with the progress of diabetes developing into retinopathy in Chinese patients with type 2 diabetes.
AGT (show AGXT Proteins) M235T and T174M variants contribute to an increased risk of developing preeclampsia (PE), and for M235T to PE severity.
Data, including data using network analysis, suggest that angiotensinogen (AGT), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 Proteins)), and prothrombin (show F2 Proteins) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
The AGT (show AGXT Proteins) (M235T) gene polymorphism do not seem to have a significant effect on the development of clinical properties or cardiovascular comordities of acromegalic patients.
Angiotensin II has a role in increasing glomerular permeability by beta-arrestin mediated nephrin (show NPHS1 Proteins) endocytosis
After donor nephrectomy, increasing uAGT (show DPAGT1 Proteins) levels can be the result of activation of the intrarenal renin (show REN Proteins)-angiotensin system affecting the compensatory changes in the remaining kidney.
ANG II is up-regulated in serum and heart tissues of mice with EAM and that ANG II significantly drives monocyte/macrophage infiltration through the C-C chemokine receptor 2/5 (CCR2/5) axis.
results established that A20 (show TNFAIP3 Proteins) is involved in the renoprotective effect by calcitriol via negatively modulating the NF-kappaB (show NFKB1 Proteins) pathway and necroptotic pathway in AngII-induced renal injury.
NLRP3 (show NLRP3 Proteins) gene deletion attenuates Ang II-induced NLRP3 (show NLRP3 Proteins) inflammasome activation, phenotypic transformation from a contractile phenotype to a synthetic phenotype and proliferation in primary mice Vascular Smooth Muscle Cells.
adipocyte-derived Agt (show AGXT Proteins) has essentially no contribution to the plasma concentration and no impact on blood pressure compared to liver-derived Agt (show AGXT Proteins).
Lung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 (show ANGPT2 Proteins) levels and plasma PREP (show PREP Proteins) activity, although no direct link between both phenomena could be shown.
Inhibition of TLR4 (show TLR4 Proteins) ameliorates AngII-impaired cavernosal relaxation, decreases TNF-alpha (show TNF Proteins) levels, and restores Nitric Oxide bioavailability, demonstrating that TLR4 (show TLR4 Proteins) partly mediates AngII-induced cavernosal dysfunction.
Our study is the first to show the important role of IL-6 (show IL6 Proteins) in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) and EndoG (show ENDOG Proteins)/MEF2A (show MEF2A Proteins) pathway that affects cardiac hypertrophy during AngII stimulation.
this study demonstrated that Ang II could increase TRPC6 (show TRPC6 Proteins) induced Ca(2 (show CA2 Proteins)+) influx and enhance autophagy through increasing reactive oxygen species levels in podocytes, and autophagy could protect Ang II-treated podocytes.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor (show AGTRAP Proteins).
Results suggest the involvement of angiotensin II (Ang II), through its angiotensin type-1 receptor (AT1R (show AGTRAP Proteins)) in the inflammation induced by Aah (show ASPH Proteins) venom, in the heart and the aorta.
In conclusion, endothelial vWF (show VWF Proteins) knockdown prevented angiotensin II-induced ET-1 (show EDN1 Proteins) upregulation through attenuation of NOX-mediated O2- production.
Data suggest that intra-adrenal metabolism of Ang II to Ang III is required for zona glomerulosa cell-mediated relaxation of adrenal arterioles but not for aldosterone secretion.
NADPH oxidase (show NOX1 Proteins) plays an important role in proMMP-2 expression and activation and MMP-2 (show MMP2 Proteins) mediated SMC (show DYM Proteins) proliferation occurs through the involvement of Spm (show NPC1 Proteins)-Cer (show CBLN1 Proteins)-S1P (show MBTPS1 Proteins) signaling axis under ANG II stimulation of PASMCs
The metabolism of angiotensin II (Ang II) to angiotensin III (Ang III) and its role in the vasorelaxation response in adrenal arteries are reported.
The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Proteins)) sites induced by PKC-Beta (show PRKCB Proteins) activation or AGT, which inhibits insulin (show INS Proteins)-induced p-Tyr (show TYR Proteins) sites on IRS2 (show IRS2 Proteins) and its signals in endothelial cells.
Data suggest up-regulation of AGT in granulosa cells and of Ang II in follicular fluid during preovulatory period; Ang II appears to amplify stimulatory effects of luteinizing hormone on secretion of progesterone/prostaglandins by granulosa cells.
Data suggest that angiotensin II promotes uptake/accumulation of iron (non-transferrin (show Tf Proteins) bound iron) into vascular endothelial cells; such iron accumulation appears to depend on activation of angiotensin type 1 receptor and promotes oxidative stress.
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
Fetal adrenal cells in primary culture respond to angiotensin-II by increasing aldosterone production and aldosterone synthase (show CYP11B2 Proteins) [P450c18/CYP11B2 (show CYP11B2 Proteins)] activity.
ANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
alpha-1 antiproteinase, antitrypsin
, angiotensin I
, angiotensin II
, serine (or cysteine) proteinase inhibitor
, serpin A8
, angiotensin ll
, angiotensinogen (PAT)
, zC8A9.1 (angiotensinogen )
, Serpin A8