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We identify the cytokine cardiotrophin 1 (CT1) as a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity
a transcriptional factor, Myc-associated zinc finger protein (MAZ (show MAZ Antibodies)), plays an important role in ADAM10 (show ADAM10 Antibodies) transcription in response to CT-1 in neural stem/progenitor cells.
CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.
non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.
This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches.
biliary epithelium-derived CT-1 may exert a profibrogenic potential in PCLD (show PRKCSH Antibodies).
Data show that cardiotrophin-1 is positively related to brachial-ankle pulse-wave velocity (baPWV) independent of traditional cardiometabolic risk factors for arterial stiffness.
this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin (show INS Antibodies) sensitivity in humans.
Study correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension.
CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia, and may mediate myocardial hypertrophy and dysfunction.
These results suggest that CT-1 may be a potent candidate for the early prevention and treatment of Alzheimer disease.
Identify cardiotrophin-1 as a powerful cytokine promoting mesenchymal stromal cell engraftment and thus improving cell therapy of the infarcted myocardium.
CT-1 mRNA levels in adipose tissue showed significant circadian fluctuations in young WT mice. Clock genes displayed a circadian rhythm in adipose tissue of both wild-type (WT) and CT-1-/- mice. However, the pattern was altered in CT-1-/- mice toward a lower percentage of the rhythm or lower amplitude, especially for Bmal1 (show ARNTL Antibodies) and Clock.
Cardiotrophin-1 modulates the production of adipokines in vitro and in vivo, suggesting that the regulation of the secretory function of adipocytes could be involved in the metabolic actions of this cytokine.
Nuclear translocation of CT-1 regulates cardiomyogenesis of ES cells and involves calcium, NO, ROS (show ROS1 Antibodies) as well as CT-1 regulated signaling pathways.
Data suggest that Ctf1 up-regulates lipolysis in white adipocytes via 1) induction of perilipin (show PLIN1 Antibodies), 2) activation of hormone sensitive lipase (show LIPE Antibodies) (via phosphorylation by PKA), and 3) inactivation of adipose triglyceride lipase (show PNPLA2 Antibodies) (via up-regulation of G0S2 (show G0S2 Antibodies)).
Cardiotrophin-1 (CT-1) is a hepatoprotective cytokine that modulates fat and glucose metabolism. Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 and its therapeutic potential in non-alcoholic fatty liver disease.
The transgenic expression of CTF1 brought about a marked improvement on cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease.
CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes
CT-1 may be a major regulator of arterial stiffness with a major impact on the aging process.
CT1 (show SLC6A8 Antibodies) decreases cell death through a mechanism related to Stat3 (show STAT3 Antibodies) and Akt (show AKT1 Antibodies) phosphorylation and activation of calpastatin (show CAST Antibodies) in D-galactosamine-treated hepatocytes.
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene.
, cardiophin 1