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The results demonstrate that cystatin B (show CSTB Proteins) interferes with the STAT-1 (show STAT1 Proteins) signaling and IFN-beta-antiviral responses perpetuating HIV in macrophage reservoirs.
The review focuses on the value of the type I and III interferon (show IFNA Proteins) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
This review briefly discusses the dysregulation of main T cell subpopulations in CNS autoimmunity and summarized the T cell targeted effects of endogenous and exogenous IFN-beta in health and EAE/MS, with emphasis on the direct actions of IFN-beta on each T cell subset involved in the disease.
c-Cbl (show CBL Proteins) negatively regulates IFN-beta signaling and cellular antiviral response by promoting IRF3 (show IRF3 Proteins) ubiquitination and degradation.
YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1 (show TBK1 Proteins)/IKBKE (show IKBKE Proteins) kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE (show IKBKE Proteins).
The effect of topical TREX1 (show TREX1 Proteins) knockdown and local interferon (show IFNA Proteins) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.
this study shows that the IFN-beta/STAT1 (show STAT1 Proteins) pathway is dysregulated in inflammatory bowel disease
results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 Proteins)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (show IKBKE Proteins) and SPL (show SGPL1 Proteins), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 Proteins)
results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.
This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS (show MAVS Proteins).
In experimental autoimmune encephalomyelitis, IFN-beta inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) axis and p38 (show CRK Proteins), JNK (show MAPK8 Proteins)-MAPK (show MAPK1 Proteins), as well as the regulation of mTOR (show FRAP1 Proteins) complexes. Moreover, IFN-beta inhibited Th17 differentiation and influenced the acetylation of the Il17a (show IL17A Proteins) and Opn (show SPP1 Proteins) gene promoters. IFN-beta plays a role in Th17 differentiation partly through the inhibition of OPN (show SPP1 Proteins).
Rb selectively inhibits innate IFN-beta production by enhancing deacetylation of Ifnb1 promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases.
The TBK1 (show TBK1 Proteins) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (show TBK1 Proteins).
this study shows that poly I:C treated PAR-1 (show MARK2 Proteins)-/- mice given the thrombin (show F2 Proteins) inhibitor dabigatran etexilate exhibited less IFNbeta and CXCL10 (show CXCL10 Proteins) expression in the spleen and plasma
The data demonstrate that an atypical TLR7 (show TLR7 Proteins) signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7 (show TLR7 Proteins)-driven type I IFN response plays an important role in determining the outcome of plague.
Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 (show IL6 Proteins) and IFN-beta promoter regions through down-regulating Kdm6a (show KDM6A Proteins) expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 (show IL6 Proteins) and IFN-beta.
Extracellular ATP reduces the replication of VSV, Newcastle disease virus, murine leukemia virus and HSV in vivo and in vitro through the P2X7 receptor (show P2RX7 Proteins); ATP increases IFN-beta expression. Mechanistically, ATP facilitates IFN-beta secretion through P38 (show CRK Proteins)/JNK (show MAPK8 Proteins)/ATF-2 (show ATF2 Proteins) signaling pathways, which are crucial in promoting antiviral immunity.
BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
The data confirm the involvement of EHMT2 (show EHMT2 Proteins) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (show EHMT2 Proteins) inhibition.
The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (show IRF3 Proteins) degradation.
These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (show IFNA Proteins)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.
Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.
Porcine deltacoronavirus nsp5 (show SPECC1 Proteins), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (show IKBKG Proteins).
Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (show IRF3 Proteins) phosphorylation.
Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (show IRF3 Proteins) promoter activities.
poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.
DDX41 (show DDX41 Proteins) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.
VIral NS4 (show SOS1 Proteins) protein antagonizes beta interferon (show IFNA Proteins) expression by targeting the NF-kappaB (show NFKB1 Proteins) essential modulator.
Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.
Expression of LSm14A (show LSM14A Proteins) in HEK293 or Marc (show CCL7 Proteins)-145 cells enhanced activities of IFN-beta and NF-kappaB (show NFKB1 Proteins) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (show LSM14A Proteins) is a potential signal molecule (show WNT4 Proteins) in the IFN-beta pathway.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (show IFNA Proteins)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (show IFNA Proteins) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages
Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Proteins) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
suppresses the growth of rat glioma cells
, fibroblast interferon
, interferon beta
, interferon, beta 1
, interferon beta-1
, interferon beta 1
, interferon type B
, interferon, beta 1, fibroblast
, IFN-alpha/beta receptor 2
, interferon alpha/beta receptor 2
, interferon, beta; receptor
, interferon-alpha/beta receptor 2
, interferon-alpha/beta receptor beta chain
, type I interferon receptor 2