Browse our anti-IL-4 (IL4) Antibodies

Human Interleukin 4 (IL4) interaction partners

1. Results show that higher levels of black carbon (BC) were associated with lower methylation of IL4 promoter CpG-48 5 days later and increased FeNO. The magnitude of association between BC exposure and demethylation of IL4 CpG-48 measured 5 days later appeared to be greater among seroatopic children, especially those sensitized to cockroach allergens.

2. Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.

3. the effects of IL4 gene polymorphisms on cancer risk may vary by cancer type and by ethnicity.

4. these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 (show STAT6 Antibodies) pathways.

5. we identified a subgroup of CVID (show TNFRSF13B Antibodies) patients with defective IL-4 signaling in T cells, with severe clinical features of inflammation and autoimmunity.

6. In dermatomyositis muscle specimens, IL-4 and IFN-g (show IFNG Antibodies) levels were positively correlated, while no correlation was observed between IL-17 (show IL17A Antibodies) and the other two cytokines. Moreover, IL-4 and IFNg (show IFNG Antibodies) levels were significantly negative correlated with muscle strength grades for the deltoid muscle

7. The difference between allelic and genotypic frequencies of interleukin-4 (-590C/T) between patients and controls was not significant (p = 0.46).

8. Data suggest that miRNA-340/429, which targeted IL-4, might be a potential approach for cancer treatment.

9. this paper shows that expression of non-secreted IL-4 is associated with histone deacetylase (show HDAC1 Antibodies) inhibitor-induced cell death, histone acetylation and c-Jun (show JUN Antibodies) regulation in gamma/delta T-cells

10. Human CCL1 (show CCL1 Antibodies) gene is selectively targeted by AhR (show AHR Antibodies) in M(IL-4) macrophage. IL-4-induced epigenetic modification potentiates AhR (show AHR Antibodies)-mediated CCL1 (show CCL1 Antibodies) expression.

Mouse (Murine) Interleukin 4 (IL4) interaction partners

1. In the lung, surfactant protein A (show GPR153 Antibodies) (SP-A (show SFTPA1 Antibodies)) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection.

2. Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.

3. NK cells activated by IL-4 in cooperation with IL-15 (show IL15 Antibodies) exhibit distinctive characteristics with enhanced immunologic cytotoxicity.

4. we defined a molecular mechanism for IL-4 downregulation of involucrin (show IVL Antibodies) in keratinocytes, which may play an important role in the pathogenesis of AD.

5. In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 (show CCL2 Antibodies) signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model

6. T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.

7. Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.

8. this study shows that environmental IL-4 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development

9. IL-4 and IL-13 (show IL13 Antibodies) are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.

10. These observations suggest that IL-4 and IL-13 (show IL13 Antibodies) likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (show HAND1 Antibodies) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.

Cow (Bovine) Interleukin 4 (IL4) interaction partners

1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG Antibodies) occurring after parturition and an increase in IL-4 production before calving.

2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Antibodies) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

1. IL-4- and IL-10 (show IL10 Antibodies)-producing invariant NKT (show SLC22A6 Antibodies) cells inhibit the Th1 (show TH1L Antibodies) cell response, but not the Th17 cell response

2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 Antibodies) secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

2. IL-4 and STAT6 (show STAT6 Antibodies) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Antibodies) biased, interferon-gamma (show IFNG Antibodies) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Antibodies) production by T cells is mature.

2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 Antibodies).

Rhesus Monkey Interleukin 4 (IL4) interaction partners

1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.