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anti-Human IL11 Antibodies:
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Human Monoclonal IL11 Primary Antibody for ELISA - ABIN2474923
Turner: Ethical problems in the genes. in Nature 1992
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Human Monoclonal IL11 Primary Antibody for ELISA, WB - ABIN966389
Cockrell, Gorman, Hord,: Endogenous interleukin-11 (IL-11) levels in newly diagnosed children with acquired severe aplastic anemia (SAA). in Cytokine 2004
Show all 2 Pubmed References
The results indicate that miR (show MLXIP Antibodies)-23b regulates IL-11 and IL-11Ralpha expression, and it might act as an anti-oncogenic agent in the progression of Hepatocellular Carcinoma by directly downregulating IL-11 expression.
It has been concluded that the renal cell carcinoma (show MOK Antibodies) risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 (show BHLHE41 Antibodies) expression which, in turn, induces IL-11, a member of the IL-6 (show IL6 Antibodies) cytokine family.
The results indicated that miR (show MLXIP Antibodies)-124a has an important role as a tumor suppressor gene by targeting IL-11.
we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex.
Studied the role of ZEB1 (show ZEB1 Antibodies)-AS1 (show PTGDR Antibodies), and it's association with IL-11, in promoting STAT3 (show STAT3 Antibodies) activation in B-lymphoblastic leukemia.
IL-11, an IL-6 (show IL6 Antibodies) Family Cytokine, promotes Non-Small Cell Lung Cancer cell proliferation in vitro and tumorigenesis in vivo.
Cancer-associated fibroblasts treated with cisplatin facilitate chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 (show STAT3 Antibodies) signaling pathway.
results reveal a central role of IL-11 in fibrosis and we propose that inhibition of IL-11 is a potential therapeutic strategy to treat fibrotic diseases
up-regulates GR (show PDIA4 Antibodies)P78 in the placenta
The identification of the miR (show MLXIP Antibodies)-206/TWF1 (show TWF1 Antibodies)/MKL1 (show MKL1 Antibodies)-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis
Consistent with these in vitro findings, IL-11 promoted HSC (show FUT1 Antibodies) engraftment in a mouse model of AA, an effect that was attenuated in cells overexpressing miR (show MLXIP Antibodies)-204-5p. The reduction in miR (show MLXIP Antibodies)-204-5p levels is an integral component of IL-11 signaling that may play an essential role in treating aplastic anemia (AA).
activates PDIA4 (show PDIA4 Antibodies) in placenta
these findings suggest that classic signalling rather than trans-signalling is the mode by which IL-11 promotes gastric tumourigenesis.
Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women.
IL-11-mediated STAT3 (show STAT3 Antibodies) signaling not only reduces hepatocellular apoptosis, but also inhibits inflammatory responses.
IL-1 (show IL1A Antibodies) signaling antagonizes IL-11/STAT3 (show STAT3 Antibodies) mediated pathology and the genetic deletion of IL-1RT1 results in increased tumor burden.
PGF2alpha inhibits adipocyte differentiation by means of an IL-11 mediated autocrine negative feedback loop, that acts via gp130 (show LRPPRC Antibodies) to block adipogenesis through the essential actions of the STAT1 (show STAT1 Antibodies) transcription factor.
Data indicate that colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS (show PMP22 Antibodies) treatment, with enhanced colonic IL-6 (show IL6 Antibodies) and IL-11 release and Stat3 (show STAT3 Antibodies) phosphorylation.
IL-11 reduced the production of reactive oxygen species.
IL-11 therefore drives a pathway that enhances HSPC (show PSMA7 Antibodies) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk (show SH2B3 Antibodies).
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, adipogenesis inhibitory factor