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anti-Human IL15RA Antibodies:
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Mouse (Murine) Polyclonal IL15RA Primary Antibody for FACS, WB - ABIN4900230
Sikora, Jaffarzad, Hailemichael, Gelbard, Stonier, Schluns, Frasca, Lou, Liu, Andersson, Hwu, Overwijk: IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 15 Pubmed References
Human Polyclonal IL15RA Primary Antibody for CyTOF, FACS - ABIN4900622
Müller, Waldmann, Kruhlak, Dubois: Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells. in The Journal of biological chemistry 2012
Show all 14 Pubmed References
Mouse (Murine) Polyclonal IL15RA Primary Antibody for CyTOF, FACS - ABIN4900232
McCullar, Oostendorp, Panoskaltsis-Mortari, Yun, Lutz, Wagner, Miller: Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. in Experimental hematology 2008
Show all 7 Pubmed References
Human Monoclonal IL15RA Primary Antibody for CyTOF, FACS - ABIN4900623
Duitman, Orinska, Bulanova, Paus, Bulfone-Paus: How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. in Molecular and cellular biology 2008
Show all 4 Pubmed References
Human Monoclonal IL15RA Primary Antibody for FACS - ABIN4898089
Arneja, Johnson, Gabrovsek, Lauffenburger, White: Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. in Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 2 Pubmed References
Human Polyclonal IL15RA Primary Antibody for IF (p), IHC (p) - ABIN747893
Yoon, Johnson, Xu, Martin, Martin, Montanaro: Comparative proteomic profiling of dystroglycan-associated proteins in wild type, mdx, and Galgt2 transgenic mouse skeletal muscle. in Journal of proteome research 2012
Mouse (Murine) Monoclonal IL15RA Primary Antibody for CyTOF, FACS - ABIN4900231
Holmkvist, Pool, Hägerbrand, Agace, Rivollier: IL-18Rα-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness. in European journal of immunology 2016
Men with the IL-15Ralpha 1775AA genotype spent more time in light intensity physical activity (39.4 +/- 2.4 hr/week) than men with the CC genotype (28.6 +/- 2.3 hr/week, (p = .009).
circulating IL-15 and IL-15Ralpha concentrations are reduced in lean and obese physically active people
IL-15/IL-15Ralpha signaling pathway is activated in skeletal muscle in response to a session of resistance exercise.
IL-15 and IL-15Ralpha genes in samples from the Spanish Consortium for Genetics of Celiac Disease (CEGEC) collection, identifying two regulatory single-nucleotide polymorphisms (SNP) that might be associated with celiac disease
this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI enhances antitumor activity of anti-PD-1 treatment and is a promising approach to stimulate host immunity
this study describes variants of splicing of IL-15Ra expressed in intestinal epithelial cells, and identifies those variants with the ability of binding IL-15 and following the secretory pathway, as well as determines if any of these variants are regulated by methylation of DNA
15Ralpha/15 complexes represent a potent adjuvant for augmenting the efficacy of adoptive immunotherapy. Such cell-bound or soluble 15Ralpha/15 complexes could be developed for use in combination immunotherapy approaches.
Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Ralpha mRNA-engineered designer DC.
The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery.
significant association of rs2228059 with ossification of the posterior longitudinal ligament of the spine in Chinese Han population
Report Il15Ralpha levels in synovial fluid from rheumatoid arthritis patients.
NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Ralpha expression
IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Ralpha production and suggest that targeting IRF-1 and IL-15/IL-15Ralpha may be effective in reducing I/R injury associated with LTx.
Coexpression of IL15RA and IL15 was also sufficient to activate peripheral blood mononuclear cells.
Circulating levels of IL-15 and IL-15Ralpha seem to reflect visceral distribution of adipose tissue; epicardial fat may be a potential source of both IL-15 and IL-15Ralpha.
our study provides strong evidence that the functional IL-15RA rs2228059 A>C polymorphism may contribute to the risk of ESCC.
We show that a gene transfer approach using recombinant adenovirus to express IL-15 and IL-15Ralpha in murine TRAMP-C2 prostate or TS/A breast tumors induced antitumor immune responses
This present study demonstrated that IL15RA rs2228059 A > C polymorphism might modify Gastric cardiac adenocarcinoma susceptibility
Data suggest that the Interleukin (IL)-15 and interleukin 15 receptor alpha (IL-15.IL-15Ralpha) complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15Ralpha complex for their own proliferation and survival.
Data indicate that tumor necrosis factor-alpha (TNF) abolishes nuclear localization of IL-15 and IL-15Ralpha by acting on chromosomal region maintenance 1 (CRM1), and it facilitates exocytosis of IL-15 with the involvement of ADP-ribosylation factor 6 (ARF6).
data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion.
these data support that IL15RA plays a cell-autonomous role in osteoblast function and bone mineralization
IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes.
this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor
These data provide additional evidence to implicate IL-15Ralpha as a regulator of skeletal muscle phenotypes through effects on the mitochondrion, and suggest these effects are driven by alterations to the mitochondrial proteome.
Spontaneous cage activity was not different and IL-15 protein levels were lower in male and female mIl15ra(fl/fl)/Cre(+) mice.
Despite being protected against diet induced obesity, IL-15R alpha knockout mice are hyperglycemic and insulin-resistant.
Signaling through IL-15Ralpha regulates the development of gammadelta-17 cells early in ontogeny.
IL-15 directly induces pro-oxidative gene expression in primary myogenic cultures. Primary myogenic cultures require IL-15RA to respond to IL-15.
lower frequencies of IL-15Ralpha expression in PBMCs of Behcet's disease-like symptomatic mice
we found that aging-related functional NK cell deficiency was completely reversed by injecting soluble IL-15/IL-15Ralpha complexes.
Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.
a greater mitochondrial density and mitochondrial DNA content was found in fast muscles from IL-15-Receptor-alpha KO mice that was not due to the presence of smaller muscle fibers.
IL-15 is produced and secreted only as a heterodimer with IL-15Ralpha.
IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells.
Stage 3 thymic invariant natural killer NKT cells are specifically reduced in IL-15Ralpha-deficient mice, whereas the acquisition of natural killer (NK) receptors occurs at stage 3 IL15-dependent thymic cell development.
Different levels of IL-15 trans-presentation are required for different natural killer (NK) cell developmental events to reach full maturation status
IL-15 receptor alpha has a role in endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles
The disrupted circadian rhythm of temperature and activity in the IL15Ralpha KO mice after LPS suggests that upregulated IL15 receptors may serve a beneficial role to counteract the consequences of neuroinflammation.
IL15 is essential to maintain neurochemical homeostasis and thereby plays a role in preventing neuropsychiatric symptoms.
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
interleukin-15 receptor subunit alpha
, interleukin 15 receptor alpha
, interleukin 15 receptor, alpha
, interleukin 15 receptor, alpha chain
, IL-15 receptor subunit alpha