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anti-Human IL2 Receptor beta Antibodies:
anti-Rat (Rattus) IL2 Receptor beta Antibodies:
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Mouse (Murine) Monoclonal IL2 Receptor beta Primary Antibody for BR, FACS - ABIN1177313
Alleva, Kaser, Monroy, Fenton, Beller: IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition. in Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) Monoclonal IL2 Receptor beta Primary Antibody for FACS - ABIN2688932
Bendelac: Mouse NK1+ T cells. in Current opinion in immunology 1995
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Human Monoclonal IL2 Receptor beta Primary Antibody for FACS - ABIN4897038
Zheng, Jones, Shi, Wiseman, Marr, Berenger, Huston, Gill, Krensky, Kubes, Mody: Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal IL2 Receptor beta Primary Antibody for CyTOF, FACS - ABIN4900009
Rose, Lambotte, Pallier, Delfraissy, Colle: Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human Monoclonal IL2 Receptor beta Primary Antibody for Func, FACS - ABIN610366
Chapman, An, Barton, Jahn: SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. in The Journal of biological chemistry 1994
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Human Monoclonal IL2 Receptor beta Primary Antibody for FACS - ABIN2688931
Ishikawa, Uchiyama, Kamio, Onishi, Kodaka, Okuma: IL-4 down-regulates IL-2 receptor p75 by accelerating its endocytosis. in International immunology 1991
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Mouse (Murine) Monoclonal IL2 Receptor beta Primary Antibody for FACS, IP - ABIN2688930
Furse, Malek et al.: Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to ... in European journal of immunology 1994
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Human Monoclonal IL2 Receptor beta Primary Antibody for FACS - ABIN4897036
Le Friec, Sheppard, Whiteman, Karsten, Shamoun, Laing, Bugeon, Dallman, Melchionna, Chillakuri, Smith, Drouet, Couzi, Fremeaux-Bacchi, Köhl, Waddington, McDonnell, Baker, Handford, Lea, Kemper: The CD46-Jagged1 interaction is critical for human TH1 immunity. in Nature immunology 2012
Rat (Rattus) Monoclonal IL2 Receptor beta Primary Antibody for FACS - ABIN2478318
Park, Hanke, Hünig et al.: Identification and cellular distribution of the rat interleukin-2 receptor beta chain: induction of the IL-2R alpha- beta+ phenotype by major histocompatibility complex class I recognition during T ... in European journal of immunology 1996
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Mouse (Murine) Monoclonal IL2 Receptor beta Primary Antibody for FACS, IP - ABIN2478322
Tanaka, Tsudo, Karasuyama, Kitamura, Kono, Hatakeyama, Taniguchi, Miyasaka: A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. in Journal of immunology (Baltimore, Md. : 1950) 1991
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Here we have developed a novel CAR construct capable of inducing cytokine signaling after antigen stimulation. This new-generation CD19 CAR encodes a truncated cytoplasmic domain from the interleukin (IL)-2 receptor beta-chain (IL-2Rbeta) and a STAT3-binding tyrosine-X-X-glutamine (YXXQ) motif, together with the TCR signaling (CD3z) and co-stimulatory (CD28) domains (hereafter referred to as 28-DeltaIL2RB-z(YXXQ)).
This study shows that a PTPN2-rs7234029 polymorphism is associated with ocular Behcet's disease and is strongly influenced by gender. In addition, our results suggest that the genetic association with PTPN2 may involve the regulation of PTPN2 mRNA expression and cytokine secretion.
Chimeric fusion protein of interleukin 2 (IL2) and its receptor interleukin 2 receptor, beta protein (IL2Rbeta) enhances antitumor activity of natural killer NK92 cells.
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
Studies indicate many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
IL2RB thr-450 phosphorylation is a positive regulator for receptor-IL-2 complex stability and activation of signaling molecules.
An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA positive Rheumatoid arthritis patients.
CD112 downregulation resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells.
IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis.
in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes.
This is the first report demonstrating that heterodimeric combinations of IL-2R and IL-6R subunits are functional for signaling.
IL2RA and IL2RB as promising candidate genes for inflammatory bowel diseases(IBD) and suggesting a potential role of IL2R in the pathogenesis of IBD, likely involves regulatory T cells.
MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS in a case-control study analyzing allele frequencies and linkage disequilibrium.
Suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation.
Data indicate that the two genetic variants within IL-2RA and IL-2RB are not associated with genetic susceptibility to rheumatoid arthritis (RA) in Han Chinese.
Data indicate that both CgammaCR-CD127(+)composed of Interleukin-7 (IL-7) tethered to IL-7Ralpha/CD127, and CgammaCR-CD122(+) CD8(+) T((E/CM)) engraft in mice and persist in an absence of exogenous cytokine administration.
specific IL2/IL21, IL2RA and IL2RB polymorphisms do not seem to play a significant role on the non-anterior uveitis genetic predisposition
Expression of the IL-2 receptor beta-chain forms functional, high-affinity receptors on naive CD4+ T cells that correlates with their increased responsiveness to IL-2.
Data suggest that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells.
The larger pool of IL-2Rbeta chains in CD8+ T cells is required to sustain IL-2 signaling and contributes to the quantitatively greater proliferative response to IL-2 relative to that of CD4+ mouse primary T cell cultures.
Diabetes was accelerated in male and female NOD mice in which IL-2Rbeta signaling was modestly and selectively reduced in T cells.
Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe...
c-REL, but not IkappaBNS, controlled the generation of classical CD25(+)Foxp3(-) precursors via direct binding to the Cd25 locus; propose that CD4(+)GITR(+)CD122(+)CD25(-)Foxp3(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL
Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells.
CBP physically associates with the IL-2 receptor beta-chain. CBP, found in the nucleus in resting CTLL-2 cells, relocates to the cytoplasm after IL-2 stimulation in an MEK/ERK pathway-dependent manner. Thus, IL-2-mediated acetylation plays an important role in the modulation of cytokine signaling and T cell fate.
Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 + CD122+ and CD4 + CD25+ Treg cells.
IL-2Rbeta-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.
Thymic development of CD4+Foxp3+ regulatory T cells (Tregs) is highly dysregulated in IL-2 receptor (2Rbeta)-deficient mice.
CDCD11c+B220+CD122+ cells play an important role in xenograft rejection. Their absence in NOG mice may be critical in supporting the successful engraftment of xenotransplants.
This study demonstrated that IL-12 signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 and the lack of IL-12 signaling both prevent complete induction of tolerance.
Continuous activation of the CD122/STAT-5 signaling pathway characterize regulatory lineage differentiation in the murine thymus.
Knockout mice exhibited deficit in prepulse inhibition of acoustic startle reflex, significant reductions in acoustic startle reactivity, and modest differences in behavior in elevated plus-maze test. (IL-2/15 receptor-beta)
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice: implications for the nonredundant function of IL-2
role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites in induction of interleukin-2 receptor alpha expression by interleukin-2
Depletion of IL-2 in vivo induces memory CD8+ T cell division by an IL-15-independent but by an IL-2/15 receptor beta-dependent mechanism, implying a novel process for antigen-independent homeostasis of memory CD8+ T cells in vivo.
This study for the first time delineates the molecular mechanisms underlying regulation of mouse IL-2Rbeta gene transcription by Ets family proteins, partially with Egr-1, and thereby further elucidates the molecular basis of lymphocyte activation.
The multivesicular regions were present in the cap structure of these granules, suggesting that the uNK cells of the Tg2Rbeta mice had cytotoxic activity.
these cells make up a specialized subset of central memory T cells with distinguishable phenotypic characteristics, most notably the higher expression of CD122 and CD127
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
IL 2/15 receptor beta chain
, interleukin 2 receptor, beta
, interleukin-2 receptor subunit beta
, CD122 antigen
, IL-2 receptor subunit beta
, IL-2R subunit beta
, high affinity IL-2 receptor beta subunit
, high affinity IL-2 receptor subunit beta
, interleukin 15 receptor, beta
, interleukin 2 receptor, beta chain
, IL-15 receptor beta chain
, IL-2 receptor beta chain
, IL-2/15 receptor-beta